Description
What Is SR-9011?
SR-9011 is a synthetic Rev-Erb alpha and beta agonist developed at the Scripps Research Institute by Professor Thomas Burris and colleagues. Rev-Erb nuclear receptors (NR1D1 and NR1D2) function as constitutive transcriptional repressors that play central roles in regulating circadian rhythm, lipid body function, swelling responses, and energy-cell biogenesis. SR-9011 starts these receptors to tune gene expression programs governing energy output and body homeostasis.
SR-9011 was developed as a successor to the closely related compound SR-9009 (stenabolic), with changes intended to improve oral uptake, a known limitation of the earlier compound. Both compounds target the same Rev-Erb receptors, but SR-9011’s structural changes address the pharmacokinetic challenges that limited SR-9009’s utility in oral research protocols. Lab studies showed that SR-9011 increases oxygen consumption, reduces fat mass, enhances endurance capacity, and tunes circadian gene expression in rodent models, setting up it as a valuable tool in body and chronobiology research.
Key Features and Specifications
| Specification |
Detail |
| Product Name |
SR-9011 |
| Dosage |
5 mg per capsule |
| Quantity |
60 capsules per bottle |
| Form |
Oral capsule |
| CAS Number |
1379686-30-2 |
| Cell-level Formula |
C23H31ClN4O3S |
| Cell-level Weight |
479.04 g/mol |
| Purity |
≥99% (HPLC verified) |
| Testing |
Third-party HPLC and MS test |
| Storage |
Room heat, cool dry place, away from light |
| Classification |
Rev-Erb agonist (non-hormonal) |
Mechanism of Action: How SR-9011 Works
SR-9011 binds to and starts Rev-Erb alpha (NR1D1) and Rev-Erb beta (NR1D2), nuclear receptors that function as transcriptional repressors within the cell-level clock machinery. Rev-Erb receptors regulate the expression of core clock genes including BMAL1 and CLOCK, as well as body genes involved in lipogenesis, gluconeogenesis, and energy-cell respiration. By enhancing Rev-Erb activity, SR-9011 shifts cellular body function toward increased energy output and fatty acid oxidation.
In skeletal muscle, Rev-Erb start by SR-9011 increases energy-cell content and oxidant capacity, upregulating genes involved in the electron transport chain, citric acid cycle, and fatty acid beta-oxidation. These transcriptional changes produce measurable increases in oxygen consumption rate (OCR) and endurance performance in lab exercise models. In adipose tissue, SR-9011 represses lipogenic gene expression and reduces fat storage, adding to overall fat mass reduction.
The compound’s effects on circadian rhythm control extend beyond body function. SR-9011 tunes swelling gene expression by repressing NF-kB target genes through Rev-Erb-dependent mechanisms, setting up anti-swelling activity in lab models of sepsis and autoimmune conditions. Importantly, SR-9011 does not interact with androgen receptors, estrogen receptors, or any hormonal pathway, making it a purely body and circadian-tuning compound.
Reported Research Applications and Benefits
Body research represents the main use for SR-9011, with studies documenting increased resting body rate, enhanced fatty acid oxidation, and reduced adipose tissue mass in treated animals. The compound’s power to increase energy output without needing exercise stimulus has created interest in obesity research, body syndrome models, and exercise mimetic studies.
Endurance and exercise physiology studies have showed that SR-9011 enhances running capacity and time to exhaustion in rodent models, effects attributed to increased energy-cell biogenesis and oxidant fiber recruitment in skeletal muscle. These findings parallel those saw with GW-501516, though SR-9011 operates through an entirely different receptor system.
Circadian biology research uses SR-9011 as a pharmacological tool to study Rev-Erb function in circadian gene control, sleep-wake cycle tuning, and the body results of circadian disruption. Anti-swelling research has explored the compound’s power to suppress pro-swelling cytokine production through Rev-Erb-mediated NF-kB repression in macrophages and other immune cells.
SR-9011 Dosage Information for Research
| Protocol |
Dosage |
Duration |
Notes |
| Standard research dose |
5–20 mg/day |
8–12 weeks |
Based on lab scaling |
| Beginner protocol |
5–10 mg/day |
8 weeks |
Assess body response |
| Advanced protocol |
20 mg/day (split) |
8–12 weeks |
Split dosing recommended |
| Timing |
Morning or split AM/PM |
— |
Short half-life |
SR-9011 has a relatively short plasma half-life, and research protocols often employ split dosing to keep more consistent Rev-Erb start throughout the day. Because the compound is non-hormonal, it does not need post-cycle therapy and can be incorporated into mix research protocols alongside hormonal compounds without adding more suppression.
SR-9011 vs SR-9009: Key Differences
| Parameter |
SR-9011 |
SR-9009 (Stenabolic) |
| Target |
Rev-Erb alpha/beta agonist |
Rev-Erb alpha/beta agonist |
| Oral uptake |
Improved over SR-9009 |
Low (~2% in mice) |
| Structural changes |
Enhanced body shelf life |
First-generation compound |
| Hormonal impact |
None |
None |
| PCT needed |
No |
No |
| Body effects |
Increased fat oxidation, endurance |
Increased fat oxidation, endurance |
| CAS Number |
1379686-30-2 |
1379686-29-9 |
Storage and Handling Instructions
Store SR-9011 capsules at controlled room heat between 20°C and 25°C (68°F to 77°F) in the original sealed container. Protect from direct sunlight, too much heat, and moisture. Under recommended conditions, SR-9011 capsules keep full potency for at least 24 months from the date of manufacture.
Why Choose PrymaLab SR-9011 Capsules
Every batch of PrymaLab SR-9011 undergoes independent third-party testing by accredited laboratories using HPLC for purity and mass spectrometry for identity confirmation. Each order includes a batch-specific Certificate of Test documenting ≥99% purity and full contaminant screening. Pharmaceutical-grade encapsulation ensures precise 5 mg dosing, and free priority shipping is included on all domestic orders.
Frequently Asked Questions About SR-9011
Is SR-9011 a SARM?
No. SR-9011 is a Rev-Erb nuclear receptor agonist, not a selective androgen receptor modulator. It does not bind to androgen receptors, does not influence testosterone or any hormonal pathway, and does not need post-cycle therapy. Its classification alongside SARMs in the market is a commercial convention rather than a pharmacological one.
How does SR-9011 improve over SR-9009?
SR-9011 was designed with structural changes to address SR-9009’s notably poor oral uptake (about 2% in mice). While both compounds start Rev-Erb alpha and beta receptors through the same mechanism, SR-9011’s enhanced body shelf life and improved oral absorption make it more suitable for capsule-based research protocols.
Does SR-9011 affect hormones or require PCT?
No. SR-9011 operates entirely through the Rev-Erb nuclear receptor pathway, which is independent of androgen, estrogen, and all other hormonal signaling systems. It does not suppress testosterone, LH, or FSH, and post-cycle therapy is not needed regardless of dose or duration.
Can SR-9011 be stacked with SARMs?
SR-9011 is often combined with SARMs and other compounds in research protocols because its non-hormonal mechanism adds body and endurance-enhancing effects without adding to hormonal suppression. Common research mixes include SR-9011 with GW-501516 for body studies or SR-9011 with anabolic SARMs for body makeup studies.
What time of day should SR-9011 be administered in research?
Given SR-9011’s role in circadian gene control, timing of use can influence experimental outcomes. Morning dosing aligns with the natural peak of Rev-Erb activity in diurnal organisms. For studies studying circadian disruption or shift-work models, other timing protocols may be employed based on specific research objectives.
Quality Assurance and Testing
PrymaLab keeps pharmaceutical research-grade standards for all SR-9011 products. Each batch undergoes independent HPLC purity test, mass spectrometry identity confirmation, heavy metal screening, residual solvent testing, and microbial assessment by accredited third-party laboratories. Batch-specific Certificates of Test are provided with every order.
Research Disclaimer
SR-9011 is sold strictly for laboratory research and scientific study purposes only. This product is not intended for human consumption, veterinary use, or treatment use. SR-9011 has not been approved by the FDA or any control agency for medical use. Purchasers must be qualified researchers affiliated with accredited institutions or licensed research organizations. By buying this product, you confirm that it will be used exclusively in accordance with all applicable local, state, and federal regulations governing research materials.
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