Description
PrymaLab · Research use only
PT-141 Peptide Nasal Spray
PT-141 nasal spray: bremelanotide in bacteriostatic water, 10 mg per bottle
This PT-141 nasal spray holds bremelanotide, the cyclic melanocortin peptide first developed under the code PT-141, as a ready-made solution. Each metered spray bottle contains 10 mg of bremelanotide in bacteriostatic water, so there is no powder to dissolve. Bremelanotide research concerns its design as an alpha-MSH analogue, its action at melanocortin receptors in the brain and controlled trials that used a different route, which leaves the nasal format with little published data of its own.
Specifications
| Property | Value |
|---|---|
| Compound | PT-141 Bremelanotide |
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Theoretical mass | 1025.2 Da |
| Sequence / structure | Ac-Nle-cyclo[D-H-[D-Phe]-R-W-K]-OH (7 residues; Asp–Lys side-chain lactam; N-acetyl; free C-terminal acid) |
| Contents | PT-141: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-137 |
What is in the bottle
The bottle holds a sterile aqueous solution of bremelanotide in bacteriostatic water, with 0.9% benzyl alcohol as an antimicrobial preservative. The safety data sheet gives the peptide as 10 mg per bottle at no more than 0.1% w/v. It is the same compound as the PT-141 10 mg vial: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, theoretical mass 1025.2 Da. The SDS does not classify the peptide as hazardous. Benzyl alcohol carries statements for harm if swallowed or inhaled, serious eye irritation and possible allergic skin reactions.
Keep the bottle upright and capped at 2 to 8 °C, away from light, and do not let it freeze. General guidance on peptides in solution is in peptide storage and stability.
What the research covers
Bremelanotide is a synthetic analogue of alpha-MSH and an agonist at melanocortin receptors, among them MC3R and MC4R, which are expressed mainly in the central nervous system1. In rats, systemic PT-141 raised c-Fos immunoreactivity in hypothalamic neurons, evidence that it reached and activated cells there1. Palatin Technologies developed it as an analogue of melanotan II, itself a truncated cyclic alpha-MSH analogue2.
The main human trials did not use a nasal spray. RECONNECT, two identical 24-week phase 3 trials in premenopausal women with hypoactive sexual desire disorder, compared a non-nasal bremelanotide formulation with placebo and measured desire and distress scores as co-primary endpoints3.
None of the references on this page measured how much bremelanotide crosses the nasal lining or where it goes afterwards. The developer did run an intranasal programme in men before the phase 3 work, and by the company’s own account absorption through the nose was variable. That history, and why the programme ended, is told in the PT-141 and bremelanotide guide, while the overview of peptide nasal sprays covers what is known about the route in general.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is PT-141 nasal spray the same peptide as the PT-141 vial?
Yes. Both contain bremelanotide, the cyclic heptapeptide with CAS number 189691-06-3. The vial holds 10 mg as freeze-dried powder kept at −20 °C. The spray holds 10 mg already dissolved in bacteriostatic water and is kept cold at 2 to 8 °C, never frozen.
How much bremelanotide does the bottle contain?
10 mg per bottle, recorded on the safety data sheet at no more than 0.1% w/v, with 0.9% benzyl alcohol as the preservative. The label on the bottle states the amount and concentration for the bottle in hand.
Has bremelanotide been studied as a nasal spray?
Only thinly. The developer ran intranasal trials in men in the 2000s, and the PT-141 guide explains why that programme stopped. The phase 3 trials in women used a different route, and no reference on this page reports how much bremelanotide is absorbed through the nose.
What does the certificate cover for the spray?
It covers the lot of bremelanotide used to fill the bottle, tested in PrymaLab's own laboratory. It is not a test of the finished solution. The testing section on this page explains where certificates are published and how to check one by its number and key.
Is the spray for human use?
No. PT-141 nasal spray from PrymaLab is sold for laboratory research only. It is not approved for human or veterinary use and must not be given to people or animals. Nothing on this page describes a clinical use of it.
References
- Molinoff PB, Shadiack AM, Earle D, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003;994:96-102. DOI · PubMed
- Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 2006;27(4):921-30. DOI · PubMed
- Kingsberg SA, Clayton AH, Portman D, et al. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials. Obstet Gynecol. 2019;134(5):899-908. DOI · PubMed
Research use only
For laboratory research use only. PT-141 Peptide Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of PT-141
PT-141 is also stocked as PT-141 10mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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