Prostamax peptide is a lyophilized vial of the tetrapeptide Lys-Glu-Asp-Pro, written KEDP, the prostate-directed compound in the Khavinson bioregulator range. It shares Lys-Glu-Asp with Vesugen, Livagen and Pancragen, and differs from all three at the terminal position.
Specification Table
Prostamax chemical and handling data
| Property |
Value |
| Compound |
Prostamax |
| Sequence designation |
KEDP |
| Amino acid sequence |
Lysine-Glutamate-Aspartate-Proline |
| Sequence provenance |
Secondary sources, converging. Not traced to a single primary citation. Confirm against the lot certificate before relying on it for calculation |
| Residue count |
4 |
| Molecular weight, calculated |
487.5 g/mol, computed from standard residue masses plus water rather than quoted from a paper |
| Net charge at neutral pH |
Near neutral, one basic and two acidic residues |
| Oxidation-prone residues |
None |
| Chromophore |
None. Concentration cannot be determined by 280 nm absorbance |
| Structural note |
Proline at the carboxy terminus constrains backbone geometry and resists carboxypeptidase action |
| Compound class |
Short peptide bioregulator, cytogen subclass |
| Source tissue of the parent fraction |
Prostate tissue |
| Originating programme |
St Petersburg Institute of Bioregulation and Gerontology |
| Programme lead |
Vladimir Khavinson |
| Proposed mechanism in the literature |
Sequence-specific interaction with DNA, modulating tissue-associated gene expression |
| Mechanism status |
Hypothesis. Not independently established outside the originating programme |
| Receptor |
None identified |
| Appearance |
White lyophilized powder |
| Purity |
Per lot-specific certificate of analysis |
| Solubility |
Water soluble |
| Storage, lyophilized |
2-8°C or -20°C, protected from light and moisture |
| Regulatory status |
No approved human or veterinary formulation in any jurisdiction |
What Is a Prostate Peptide Bioregulator?
The organ phrasing outdraws Prostamax peptide in search by a wide margin, and it names the premise the whole programme rests on rather than a pharmacological class.
The St Petersburg group fractionated animal tissue extracts across several decades on the idea that an extract from a given organ contains short peptides carrying regulatory information specific to that tissue.
Prostamax came from prostate tissue in that work, which is why it is named and filed by organ. Every compound in the family follows the same convention.
The class divides in two. Cytomaxes are peptide-containing tissue extracts, which cannot be characterised completely because there is no single molecule to measure. Cytogens are laboratory-synthesised defined sequences, which can.
Prostamax is a cytogen. That means claims established for a prostate cytomax preparation do not transfer to it, and secondary sources interchange the two terms constantly.
The organ name also carries an implication about where the compound acts. That implication is inherited from the fractionation method rather than demonstrated by tissue-distribution work, and no such study across this family appears in the published record.
What Does the Terminal Proline Do?
Prostamax peptide is the only compound in this range with proline at the carboxy terminus, and that placement is structurally consequential.
Proline is the only proteinogenic amino acid whose side chain bonds back to the backbone nitrogen, forming a ring. That ring removes the amide hydrogen and sharply restricts the backbone angles the residue can adopt.
At a chain terminus the effect is protective. Carboxypeptidases work inward from the carboxy end and are poorly able to accommodate the geometry a terminal proline presents, so the residue obstructs an entire class of degradative enzyme.
Cortagen carries proline at the same position on an alanine-opening backbone, which is the only other instance in this family. The two compounds share that design feature and differ in their first residue.
Proline also produces a chromatographic behaviour worth knowing about. The peptide bond preceding a proline interconverts slowly between cis and trans geometries, and on a chromatographic timescale that can broaden a peak or split it.
A broad peak on a Prostamax chromatogram is therefore not automatically an impurity. Running the column warmer speeds the interconversion and sharpens the peak, which distinguishes isomerisation from a genuine second species.
Where Does the Prostamax Sequence Come From?
The Prostamax peptide provenance deserves stating plainly, because it is weaker than it looks and most pages selling this compound do not address it at all.
Lys-Glu-Asp-Pro appears consistently across multiple independent secondary sources, and material hosted under the Khavinson programme corroborates the family sequence set. That convergence is reasonable evidence.
What I could not do is trace it to a single primary citation stating the sequence for this compound specifically. Supplier listings largely repeat one another, and repetition across sources that share an origin is not independent confirmation.
The practical instruction follows from that gap rather than working around it. Verify by mass spectrometry against the lot in hand rather than trusting any listing, this page included.
A measured mass near 487.5 supports the assignment. A materially different figure means the vial contains something else, and given how many compounds in this family sit within a hundred daltons of each other, that is a real possibility rather than a hypothetical one.
Stating the provenance honestly is more useful to a researcher than presenting a secondary-source sequence as established fact, which is what every competitor page does.
What Prostamax Peptide Dosage Figures Are Published?
Everything below is an amount from a published study, in whichever species that study used, and the family caveats travel with each one.
Rodent work sits in the microgram per kilogram band by parenteral routes, consistent across the Khavinson range and far below where most peptides in this catalogue are studied.
The Russian clinical record describes ten to twenty day courses at amounts in the tens to low hundreds of micrograms, structured as discrete courses rather than continuous exposure.
That course structure recurs throughout the family. Anyone reproducing published work should match the schedule as well as the quantity, because the two are reported together and the schedule is rarely mentioned in secondary summaries.
No receptor affinity is known, so no single concentration can be justified from first principles and wide ranging is a requirement rather than a refinement.
Allometric scaling through body surface area is required for cross-species comparison. Body weight arithmetic alone overestimates substantially, and the FDA publishes the conversion factors.
What Should Prostamax For Sale Documentation Show?
Prostamax peptide at four residues is simple to characterise, and the near-neighbours in this family make one check more important than usual.
Measured mass against roughly 487.5. That figure is calculated from residue masses rather than quoted, so take it as the expected value and read the certificate figure as the measurement.
Sequence stated explicitly as Lys-Glu-Asp-Pro. Vesugen, Livagen, Pancragen and Prostamax all share Lys-Glu-Asp and differ only at the terminal residue, so a trade name alone identifies nothing.
Purity by reversed-phase chromatography, with the caveat about proline peak broadening above. Ask what temperature the column ran at.
Counterion identity, together with the net peptide content figure. At 487.5 daltons a single trifluoroacetate at 114 is roughly 19 percent of the associated mass.
Concentration cannot be checked by 280 nanometre absorbance, since the sequence has no aromatic residue. Quantitative amino acid analysis, or a colorimetric protein assay, is what actually works here.
How Does Prostamax Peptide Fit the Family Pattern?
Lining the sequences up rather than reading them one at a time makes the programme design visible.
Vesugen is Lys-Glu-Asp. Livagen adds alanine. Pancragen adds tryptophan. Prostamax peptide adds proline. Four compounds, one shared three-residue opening, and a terminal residue that carries the whole tissue assignment.
A parallel series opens with alanine instead: Cortagen is Ala-Glu-Asp-Pro, Cardiogen is Ala-Glu-Asp-Arg, Bronchogen is Ala-Glu-Asp-Leu and Epitalon is Ala-Glu-Asp-Gly.
Read together, the two series make the central claim explicit, and one residue, at one position, is supposed to determine which organ a peptide addresses.
That is a strong claim and an unusually testable one. Running the whole set side by side at matched molar concentrations in a single assay would either support tissue specificity or constrain it sharply.
No such comparison appears in the published record after five decades, and the material cost of running it would be trivial.
How Should Prostamax 20mg Be Handled?
Prostamax peptide at twenty milligrams and roughly 487.5 daltons is approximately 41 micromoles, a large molar quantity by the standards of this range.
The sequence carries no cysteine, no methionine and no tryptophan, so the degradation routes that trouble most peptides simply are not available. That holds across this family apart from Pancragen and Thymogen.
Keep the dry powder sealed, dark and dry at 2 to 8 degrees Celsius or below. Ordinary refrigeration is enough for something this durable.
Water solubility is good, so run diluent gently down the inside of the vial and swirl once or twice.
In solution, hold at 2 to 8 degrees and divide before any freeze, although this compound survives thaw cycles better than nearly anything else here.
Record lot, measured mass, counterion, net peptide content, diluent, volume, concentration and date.
A closing note on what the organ names would need to earn. Tissue-distribution work using labelled peptide would settle the question directly for the whole family at once.
Radiolabelled or fluorescently tagged short peptides are routine to prepare, and the compounds are cheap enough that a full family panel would cost less than most single-compound studies.
The absence of that work after five decades is the clearest gap in this literature, and it is the gap that would either vindicate the programme naming or retire it.
One further point on the proline. Because it appears at the terminus in only two compounds here, Prostamax and Cortagen, those two form a natural pair for testing whether terminal rigidity affects anything measurable.
They differ at the first residue and share the last, which is the inverse of the Testagen and Epitalon pairing, and between them the four compounds would let a single experiment separate opening-residue effects from terminal-residue effects.
That design falls out of the sequence set without anyone needing to invent it.
Published Literature
References verified against the publisher record. This literature originates almost entirely from one research programme, which bears on how it should be weighted.
- Khavinson VK, Malinin VV. Gerontological Aspects of Genome Peptide Regulation. Karger, Basel; 2005.
- Khavinson VK. Neuroendocrinology Letters. 2002;23(Suppl 3):11-144.
- Anisimov VN, Khavinson VK. Critical Reviews in Oncology/Hematology. 2010;74(1):46-66.
- Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF. Biochemistry (Moscow). 2011;76(11):1210-1219.
- Khavinson VK, Solovyov AY, Zhilinsky DV, Shataeva LK, Bandaletova TY. Bulletin of Experimental Biology and Medicine. 2012;153(4):500-505.
Frequently Asked Questions
What is Prostamax peptide?
A lyophilized vial of the tetrapeptide Lys-Glu-Asp-Pro, written KEDP, the prostate-directed compound in the Khavinson bioregulator range. Sold for laboratory research alone. No approved formulation exists anywhere.
What is a prostate peptide bioregulator?
It names the programme premise rather than a pharmacological category. Prostamax came from prostate tissue during fractionation, which is why it is named and filed by organ rather than by sequence.
Does cytomax literature apply to it?
No. Cytomaxes are tissue extracts of unknown composition, cytogens are defined synthetic sequences. Prostamax is a cytogen, and claims established for one class do not transfer to the other.
What does the terminal proline do?
It obstructs carboxypeptidases. Proline is the only proteinogenic residue whose side chain bonds back to the backbone nitrogen, and at a chain terminus that geometry is poorly accommodated by enzymes working inward from that end.
Does proline affect the chromatography?
Yes. The bond preceding a proline interconverts slowly between cis and trans geometries, which on a chromatographic timescale can broaden or split a peak. A broad peak here is not automatically an impurity.
How can isomerisation be distinguished from impurity?
By running the column warmer. Raised temperature speeds the cis-trans interconversion and sharpens the peak, whereas a genuine second species stays separate regardless of temperature.
How reliable is the sequence?
Reasonably, and less than it looks. Lys-Glu-Asp-Pro appears consistently across multiple independent secondary sources, but I could not trace it to a single primary citation for this compound specifically.
What follows from that?
Verify by mass spectrometry against the lot in hand rather than trusting any listing, this page included, and a measured mass near 487.5 supports the assignment and a materially different figure means the vial contains something else.
Why is that a real risk here?
Because Vesugen, Livagen, Pancragen and Prostamax all share Lys-Glu-Asp and differ only at the terminal residue. Several compounds in this family sit within a hundred daltons of each other, so a trade name alone identifies nothing.
What dosage figures are published?
Published rodent studies sit in the microgram per kilogram band by parenteral routes, and the Russian clinical record describes ten to twenty day courses at tens to low hundreds of micrograms.
Can concentration be checked by absorbance?
No. The sequence has no aromatic residue, so nothing absorbs at 280 nanometres. Amino acid analysis or a colorimetric protein assay is the dependable route, as with most compounds in this family.
Compliance Statement
Prostamax peptide is sold exclusively for laboratory research use. It is not a drug, food, or cosmetic product, and it is not a dietary product of any kind. It is not approved by the FDA or any comparable authority for human or veterinary use, its proposed mechanism has not been independently established, and amounts cited are figures from published studies in the species those studies used. This product is not intended to diagnose, treat, cure, or prevent any disease. It must not be given to humans or animals. Purchase is restricted to qualified researchers and institutions operating within applicable laws. All handling is the responsibility of the purchasing laboratory.
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