Description
PrymaLab · Research use only
RAD-140 (Testolone) 10mg Capsules
Testolone, a nonsteroidal SARM first described in 2011, 10 mg per capsule
RAD140, sold as testolone, is a nonsteroidal selective androgen receptor modulator (SARM): a small molecule that binds the androgen receptor and was designed to activate it more in some tissues than in others. It is not a peptide and not a steroid. This listing is a bottle of hard gelatin capsules, each holding 10 mg of RAD140 in a microcrystalline cellulose fill. The published work on RAD140 is preclinical, starting with its 2011 discovery paper.
Specifications
| Property | Value |
|---|---|
| Compound | RAD-140 (RAD140 (Testolone), selective androgen receptor modulator) |
| CAS number | 1182367-47-0 |
| Molecular formula | C20H16ClN5O2 |
| Contents | RAD-140: 10 mg per capsule |
| Form | Hard gelatin capsules containing the active substance blended with microcrystalline cellulose, packed in a sealed bottle |
| Storage, sealed | Store at room temperature (15–25 °C) in the tightly closed original container, dry and protected from light |
| Safety data sheet | PL-SDS-138 |
What is in each capsule
Each capsule contains 10 mg of RAD140, about 2.5% of the capsule contents by weight, mixed with microcrystalline cellulose inside a gelatin shell. The safety data sheet classifies RAD140 as suspected of damaging fertility or the unborn child (Repr. 2, H361) and as able to damage organs through prolonged or repeated exposure (STOT RE 2, H373), and asks for the bottle to be stored locked up. The cellulose and the shell are not classified. Keep the bottle tightly closed in its original container at 15 to 25 °C, dry and away from light.
Neither a peptide nor a steroid
RAD140 contains no amino acids, so it is not a peptide, and it has no four-ring steroid skeleton, so it is not an anabolic steroid, even though it binds the same receptor as testosterone. That difference in structure has practical consequences. Bhasin and Jasuja noted that nonsteroidal SARMs are not substrates for aromatase (CYP19) or 5α-reductase, the enzymes that act on testosterone, and that nonsteroidal and steroidal ligands interact with the androgen receptor differently1. How the SARM class compares with the peptides sold for research is set out in the guide to SARMs versus peptides.
What the research covers
Why selective modulators were made
The androgen receptor is a member of the steroid hormone receptor family and responds to circulating testosterone and to locally made dihydrotestosterone2. Because it is expressed almost everywhere, and because steroidal androgens are metabolised and cross-react with other receptors, their medical use has been limited, and SARMs were developed to activate the receptor in selected tissues2. Part of the selectivity is structural: each ligand changes the shape of the ligand-binding domain, which alters the receptor’s contacts with coregulator proteins and so the genes it regulates in a given tissue1. Coregulators themselves affect the receptor’s ligand selectivity and DNA binding, and they bring chromatin-modifying complexes to target genes3.
The RAD140 discovery paper
Miller and colleagues described RAD140 in 2011 as a potent nonsteroidal SARM and characterised it in several preclinical models of anabolic androgen action4. The abstract runs to two sentences and gives no figures, so its potency, selectivity and animal results have to be read from the full paper. Across the class, a 2009 review summarised rodent studies in which SARMs increased muscle and bone mass with varying degrees of prostate sparing1.
What is not established
None of the references here reports a controlled human study of RAD140, and the evidence that it is tissue-selective comes from animals. Nothing in this literature used capsules. What “research use only” means under US law, which turns on intended use and not on the type of compound, is explained in the are peptides legal guide.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release. Published certificates are listed on the results page and can be checked by number and key on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is RAD140 a steroid or a peptide?
Neither. RAD140 is a nonsteroidal small molecule with no amino acids. It binds the same androgen receptor that testosterone binds, but its structure shares nothing with the steroid ring system, which is why it is classed as a nonsteroidal SARM.
What does tissue-selective mean for a SARM?
That in animal studies the compound activates the androgen receptor more strongly in some tissues, such as muscle and bone, than in others, such as the prostate. Selectivity is a matter of degree measured in rodents; it does not mean the compound acts on one tissue only.
What does the safety data sheet say about RAD140?
It classifies RAD140 as suspected of harming fertility or the unborn child and as able to cause organ damage through prolonged or repeated exposure. The bottle is to be stored locked up, tightly closed, at 15 to 25 °C, dry and away from light.
Is RAD140 for human use?
No. RAD140 is a research compound with no approval as a medicine and no status as a dietary supplement. These capsules are sold to laboratories only and must not be swallowed by, or given to, people or animals.
References
- Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12(3):232-40. DOI · PubMed
- Narayanan R, Coss CC, Dalton JT. Development of selective androgen receptor modulators (SARMs). Mol Cell Endocrinol. 2018;465:134-142. DOI · PubMed
- Heinlein CA, Chang C. Androgen receptor (AR) coregulators: an overview. Endocr Rev. 2002;23(2):175-200. DOI · PubMed
- Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. DOI · PubMed
Research use only
For laboratory research use only. RAD-140 (Testolone) 10mg Capsules is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
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