Description
PrymaLab · Research use only
Semaglutide 10mg
Semaglutide in a 10 mg freeze-dried fill, made and tested as its own lot
Semaglutide, a long-acting analogue of the incretin hormone GLP-1, comes here as 10 mg of freeze-dried powder in a sealed vial, double the 5 mg main fill. Every fill holds the same molecule: 31 residues with Aib at position 8, arginine at 34 and a fatty diacid chain on lysine 26. Its literature centres on how that chain was chosen for albumin binding and on clinical trials in diabetes and obesity.
Specifications
| Property | Value |
|---|---|
| Compound | Semaglutide NN9535; GLP-1 receptor agonist |
| CAS number | 910463-68-2 |
| Molecular formula | C187H291N45O59 |
| Theoretical mass | 4113.6 Da |
| Sequence / structure | H-H-Aib-EGTFTSDVSSYLEGQAAK(2×OEG-γGlu-C18 diacid)EFIAWLVRGRG-OH (31 residues; Aib8 and Arg34 in GLP-1 numbering; Lys26 acylated with octadecanedioic acid via two OEG spacers and γ-Glu; free C-terminus) |
| Label claim | 10 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-146 |
Other fills
This is the 10 mg fill. The Semaglutide 5mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 5 mg, 15 mg, 20 mg, 30 mg.
What the research covers
The discovery team started from liraglutide and tuned the fatty acid and its linker to push albumin binding up while protecting the peptide from metabolic degradation1. Receptor binding paid for it: semaglutide’s GLP-1 receptor affinity of 0.38 nM was three-fold weaker than liraglutide’s1. Those numbers come from the discovery paper’s own assays, run alongside pharmacokinetic work in mini-pigs1. Receptor signalling, the clinical comparisons and what remains open are summarised on the Semaglutide 5 mg page.
The Semaglutide Benefits guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 10 mg vial the same compound as the 5 mg?
Yes. The sequence, side chain and theoretical mass of 4113.6 Da are identical across all five fills. The 10 mg vial is filled and tested as its own lot, so it carries a separate lot number and certificate.
How many micromoles does 10 mg represent?
Close to 2.4 µmol, from 10 mg divided by 4113.6 Da. Residual water in the powder, which the certificate reports, lowers the true peptide amount a little. Dissolved in 2 mL of bacteriostatic water it gives 5 mg/mL.
References
- Lau J, Bloch P, Schäffer L, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J Med Chem. 2015;58(18):7370-80. DOI · PubMed
Research use only
For laboratory research use only. Semaglutide 10mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Semaglutide
Semaglutide is also stocked as cagrilintide 2.5mg + semaglutide 2.5mg, Cagrilintide 5mg + Semaglutide 5mg, Cagrilintide 20mg preloaded 3ml pen and Cagrilintide 5mg. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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