Description
PrymaLab · Research use only
KPV (5mg)
KPV (Lys-Pro-Val) in the smaller 5 mg freeze-dried fill
KPV is a three-residue peptide, Lys-Pro-Val, matching the C-terminal end of alpha-MSH and studied for its effect on inflammatory signalling. This vial holds 5 mg of it as freeze-dried powder, half the 10 mg main fill, and is made and certified as a separate lot. Published work on KPV comes from intestinal cell lines and mouse colitis models.
Specifications
| Property | Value |
|---|---|
| Compound | KPV Lys-Pro-Val; α-MSH(11–13) |
| CAS number | 67727-97-3 |
| Molecular formula | C16H30N4O4 |
| Theoretical mass | 342.4 Da |
| Sequence / structure | H-KPV-OH (3 residues; free N- and C-termini) |
| Label claim | 5 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-097 |
Other fills
This is the 5 mg fill. The KPV (10mg) page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 10 mg.
What the research covers
Reviews of alpha-MSH traced most of its anti-inflammatory activity to this C-terminal tripeptide1. In intestinal epithelial cells and T cells, nanomolar KPV entered through the PepT1 transporter and reduced NF-kB activation and cytokine secretion, and oral KPV lessened chemically induced colitis in mice2. No human study appears among the cited papers. The KPV 10 mg vial page has the full research summary.
The Exploring the Benefits of KPV Peptide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 5 mg vial the same compound as the 10 mg?
Yes. Both contain H-KPV-OH, theoretical mass 342.4 Da, as freeze-dried powder. The 5 mg fill is produced and tested as a separate lot, so its lot number and certificate differ from those of the 10 mg vial.
How much KPV is 5 mg in molar terms?
About 14.6 µmol, calculated from the certificate's theoretical mass of 342.4 Da. The real figure is slightly lower because the powder holds some residual water, which the certificate reports. Dissolved in 1 mL, the vial gives roughly a 14.6 mM solution.
Why choose the 5 mg fill over the 10 mg?
A smaller fill suits work that needs less peptide per reconstituted vial, so less solution waits in the refrigerator. Sealed, it is stored like the larger fill: −20 °C, dry and away from light.
References
- Luger TA, Brzoska T. alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis. 2007;66 Suppl 3(Suppl 3):iii52-5. DOI · PubMed
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-78. DOI · PubMed
Research use only
For laboratory research use only. KPV (5mg) is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of KPV
KPV is also stocked as KPV 10mg Nasal Spray and KPV 5mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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