Description
What Is RAD-140 (Testolone)?
RAD-140, often known as testolone, is a non-steroidal selective androgen receptor modulator (SARM) developed by Radius Health, Inc. for the investigational treatment of muscle wasting conditions and hormone receptor-positive breast cancer. RAD-140 selectively binds to androgen receptors in skeletal muscle and bone tissue with high affinity while showing minimal androgenic activity in prostate and seminal vesicle tissues.
Testolone shows an anabolic-to-androgenic ratio of about 90:1, making it one of the most tissue-selective SARMs characterized in lab research. Published pharmacokinetic data show oral uptake exceeding 60 percent, with a plasma half-life of about 60 hours in primates. This extended half-life and oral dosing route distinguish RAD-140 from traditional anabolic agents that need frequent injection and carry systemic androgenic side effect profiles. The compound entered Phase I clinical trials for breast cancer in 2017, further validating its pharmacological profile.
Key Features and Specifications
| Specification |
Detail |
| Product Name |
RAD-140 (Testolone) |
| Dosage |
10 mg per capsule |
| Quantity |
60 capsules per bottle |
| Form |
Oral capsule |
| CAS Number |
1182367-47-0 |
| Cell-level Formula |
C20H16ClN5O2 |
| Cell-level Weight |
393.83 g/mol |
| Purity |
≥99% (HPLC verified) |
| Testing |
Third-party HPLC and MS test |
| Storage |
Room heat, cool dry place, away from light |
| Classification |
Non-steroidal SARM |
Mechanism of Action: How RAD-140 Works
RAD-140 functions as a full agonist at androgen receptors in muscle and bone tissue while acting as an antagonist or partial agonist in androgenic tissues such as the prostate. This tissue selectivity arises from differential cofactor recruitment at the androgen receptor, meaning RAD-140 starts distinct transcriptional programs depending on the cell type. In myocytes and osteoblasts, testolone recruits coactivator proteins that drive anabolic gene expression, promoting protein synthesis and nitrogen retention.
Lab studies in cynomolgus monkeys showed that RAD-140 at 0.1 mg/kg produced a mean body weight gain of over 10 percent in 28 days, with simultaneous reduction in LDL cholesterol and triglycerides. The compound also showed brain-safe properties in cell culture models, reducing kainate-induced neurotoxicity and amyloid-beta-induced cell death, suggesting possible uses in neurodegenerative disease research.
Importantly, RAD-140 does not undergo aromatization to estrogen, removing estrogen-related side effects common to traditional anabolic compounds. Its selectivity index in lab assays exceeds that of many other SARMs, positioning testolone as one of the most researched compounds in its class.
Reported Research Applications and Benefits
Lean mass accretion research represents the main use for RAD-140. Lab data consistently show dose-dependent increases in skeletal muscle mass without proportional increases in prostate weight, confirming the tissue-selective mechanism. Researchers studying sarcopenia, cachexia, and muscle wasting conditions have used testolone to assess anabolic interventions that spare androgenic tissues.
Bone density studies show that RAD-140 starts androgen receptors in osteoblasts, boosting bone mineralization pathways and increasing cortical bone thickness. These properties have attracted interest from researchers studying osteoporosis and age-related bone loss, very in mix protocols with other osteogenic agents.
Brain safety research has emerged as a major use area following the discovery that RAD-140 protects hippocampal neurons against amyloid-beta and kainate-induced toxicity through androgen receptor-mediated pathways. Body makeup tuning studies have documented reductions in fat mass concurrent with lean mass gains, consistent with the body effects of enhanced androgen receptor signaling in skeletal muscle.
RAD-140 Dosage Information for Research
| Protocol |
Dosage |
Duration |
Notes |
| Standard research dose |
10–20 mg/day |
8–12 weeks |
Most often studied range |
| Beginner protocol |
10 mg/day |
8 weeks |
Assess personal response first |
| Advanced protocol |
20 mg/day |
8–12 weeks |
Higher suppression possible |
| Timing |
Once daily, morning |
— |
~60-hour half-life in primates |
RAD-140 is often gave once daily in the morning due to its extended plasma half-life. Research protocols often include baseline and endpoint blood panels to track hormone levels, as testolone can suppress endogenous testosterone production in a dose-dependent manner. Post-cycle protocols with SERMs are often incorporated into research designs lasting beyond eight weeks.
RAD-140 vs RAD-150: Key Differences
| ParameterRAD-140 (Testolone)RAD-150 (TLB-150) |
| Structure |
Parent compound |
Ester prodrug of RAD-140 |
| Oral uptake |
~60% |
Possibly enhanced |
| Half-life |
~60 hours (primates) |
Extended vs RAD-140 |
| Onset |
Standard |
Possibly faster peak |
| Research maturity |
Phase I clinical trials |
Lab only |
| Tissue selectivity |
90:1 anabolic-to-androgenic |
Similar to RAD-140 |
| CAS Number |
1182367-47-0 |
1208070-53-4 |
Storage and Handling Instructions
Store RAD-140 capsules at controlled room heat between 20°C and 25°C (68°F to 77°F) in the original sealed container. Protect from direct sunlight, too much heat, and humidity. Keep capsules in their original packaging until use. Under recommended storage conditions, RAD-140 capsules keep full potency for at least 24 months from the date of manufacture. Do not freeze or expose to temperatures above 30°C.
Why Choose PrymaLab RAD-140 Testolone Capsules
Every batch of PrymaLab RAD-140 undergoes full third-party test by independent, accredited laboratories using high-performance liquid chromatography (HPLC) for purity finding and mass spectrometry (MS) for identity confirmation. Each order includes a batch-specific Certificate of Test (COA) documenting ≥99% purity, absence of heavy metals, residual solvents, and microbial contaminants.
PrymaLab employs pharmaceutical-grade encapsulation to deliver precise 10 mg dosing per capsule, providing the reproducibility that controlled research protocols demand. Full lot traceability, GMP-compliant manufacturing, and free priority shipping on all domestic orders ensure a seamless research supply chain from lab to bench.
Frequently Asked Questions About RAD-140
What is the best time to take RAD-140 for research purposes?
Most research protocols give RAD-140 once daily in the morning. The extended plasma half-life of about 60 hours in primates ensures stable circulating levels throughout the dosing interval, making precise timing less key than with shorter-acting compounds. Consistent daily use at the same time optimizes pharmacokinetic shelf life.
Does RAD-140 require post-cycle therapy in research protocols?
Research protocols lasting eight weeks or longer at doses of 10 mg per day or above often incorporate post-cycle therapy using selective estrogen receptor modulators such as enclomiphene or clomiphene. RAD-140 can suppress endogenous testosterone production in a dose- and duration-dependent manner, and PCT protocols help restore hormonal homeostasis after cessation.
How does RAD-140 differ from traditional anabolic steroids?
RAD-140 is a non-steroidal selective androgen receptor modulator with a 90:1 anabolic-to-androgenic ratio, meaning it preferentially starts androgen receptors in muscle and bone while sparing prostate and other androgenic tissues. Traditional anabolic steroids lack this tissue selectivity and can undergo aromatization to estrogen. RAD-140 does not aromatize.
What purity level should researchers expect from quality RAD-140?
Research-grade RAD-140 should test at ≥99% purity by HPLC test. Each PrymaLab batch is independently verified by third-party laboratories and ships with a Certificate of Test documenting purity, identity confirmation by mass spectrometry, and absence of contaminants including heavy metals and residual solvents.
Can RAD-140 be stacked with other SARMs in research?
Published research protocols have studied RAD-140 in mix with GW-501516 (cardarine) for body makeup studies and with MK-677 (ibutamoren) for anabolic and GH secretagogue synergy. Mix protocols need careful dose care and full blood panel tracking to assess cumulative effects on hormonal parameters.
Quality Assurance and Testing
PrymaLab keeps rigorous quality control standards for all RAD-140 products. Each batch undergoes HPLC purity test, mass spectrometry identity confirmation, heavy metal screening (arsenic, cadmium, lead, mercury), residual solvent testing, and microbial contamination assessment. All testing is conducted by independent, accredited third-party laboratories, and results are documented in batch-specific Certificates of Test available with every order. Our quality program ensures pharmaceutical research-grade consistency from synthesis through final packaging.
Research Disclaimer
RAD-140 (testolone) is sold strictly for laboratory research and scientific study purposes only. This product is not intended for human consumption, veterinary use, or treatment use. RAD-140 has not been approved by the FDA or any control agency for medical use. Purchasers must be qualified researchers affiliated with accredited institutions or licensed research organizations. By buying this product, you confirm that it will be used exclusively in accordance with all applicable local, state, and federal regulations governing research materials.
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