Description
PrymaLab · Research use only
RAD-150 (TLB-150) 5mg Capsules
TLB-150, listed as a benzoate ester of the SARM RAD140, 5 mg per capsule
RAD150, also sold as TLB-150, is described on its safety data sheet as the benzoate ester of RAD140, a nonsteroidal selective androgen receptor modulator (SARM). It is a small molecule, not a peptide. This listing is a bottle of hard gelatin capsules, each holding 5 mg of RAD150 in a microcrystalline cellulose fill. No peer-reviewed study of RAD150 itself is among the references here; the literature concerns the parent compound, RAD140, and the general chemistry of ester prodrugs.
Specifications
| Property | Value |
|---|---|
| Compound | RAD-150 (RAD150 (TLB-150), benzoate ester of RAD140) |
| CAS number | 1333223-66-7 |
| Molecular formula | C27H18ClN5O3 |
| Contents | RAD-150: 5 mg per capsule |
| Form | Hard gelatin capsules containing the active substance blended with microcrystalline cellulose, packed in a sealed bottle |
| Storage, sealed | Store at room temperature (15–25 °C) in the tightly closed original container, dry and protected from light |
| Safety data sheet | PL-SDS-139 |
What is in each capsule
The safety data sheet lists 5 mg of RAD150 per capsule, roughly 1.2% of the capsule contents by weight, with microcrystalline cellulose as the filler and a gelatin shell. It applies the same hazard classes as for RAD140: suspected of damaging fertility or the unborn child (Repr. 2, H361) and able to damage organs through prolonged or repeated exposure (STOT RE 2, H373). The filler and shell are not classified. The sheet asks for the bottle to be stored locked up, tightly closed at 15 to 25 °C, dry and protected from light.
What an ester changes, and what is assumed
Esters are one of the standard ways of making a prodrug. Rautio and colleagues defined prodrugs as bioreversible derivatives that are converted in the body, by enzymes or by chemistry, to release the active parent drug, and described them as a routine tool for changing a compound’s physicochemical, biopharmaceutical or pharmacokinetic properties1. About 5 to 7% of drugs approved worldwide can be classed as prodrugs1.
Whether RAD150 behaves that way has not been shown. How quickly, if at all, the benzoate is cleaved to give RAD140, and whether the ester binds the androgen receptor on its own, are unreported in the literature cited here. Claims that the ester gives RAD150 a longer half-life or better absorption than RAD140 therefore have no published support.
What the research covers
The parent compound
The 2011 discovery paper presented RAD140 as a potent, nonsteroidal androgen receptor modulator and tested it in a range of preclinical models of anabolic androgen action2. A 2014 study by Jayaraman and colleagues looked at it in the nervous system. In cultured rat hippocampal neurons, RAD140 reduced cell death caused by apoptotic insults as effectively as testosterone, and the protection depended on MAPK signalling, since a MAPK kinase inhibitor blocked it3. In gonadectomised adult male rats it showed androgen action in peripheral tissues that largely spared the prostate, switched on androgen-regulated genes in the brain and protected hippocampal neurons against the excitotoxin kainate3. The authors presented this as initial preclinical evidence relevant to neurodegenerative disease3.
The class it belongs to
A 2018 review traced SARMs from proof-of-concept agents to the edge of clinical use in under two decades, describing them as ligands that activate the androgen receptor in a tissue-selective way4.
What is not established
None of these studies tested RAD150. Its potency at the androgen receptor, its metabolism, whether it releases RAD140 at all and its safety are not reported in the literature cited here, so anything said about RAD150 beyond its identity is an extrapolation from RAD140. The guide to SARMs versus peptides explains how this class differs from the peptides in the catalogue.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release. Published certificates are listed on the results page and can be checked by number and key on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How is RAD150 related to RAD140?
The safety data sheet describes RAD150 as the benzoate ester of RAD140: the same core structure with a benzoic acid ester added. It is a separate compound with its own CAS number, and no published study has compared the two directly.
Does the ester make RAD150 longer acting?
That claim is common in sales copy but has no support in the literature cited here. Ester prodrugs are designed to be cleaved back to the parent drug, yet no one has published data on whether or how fast that happens with RAD150, or on its half-life.
What hazards does the safety data sheet list?
Suspected damage to fertility or the unborn child, and organ damage through prolonged or repeated exposure, the same classes it gives RAD140. Store the bottle locked up and tightly closed at room temperature, dry and protected from light.
Is RAD150 for human use?
No. RAD150 has not been studied in people at all, has no approval of any kind and is not a supplement. It is sold for laboratory research, and the capsules are not to be eaten or given to any person or animal.
References
- Rautio J, Kumpulainen H, Heimbach T, et al. Prodrugs: design and clinical applications. Nat Rev Drug Discov. 2008;7(3):255-70. DOI · PubMed
- Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-9. DOI · PubMed
- Jayaraman A, Christensen A, Moser VA, et al. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014;155(4):1398-406. DOI · PubMed
- Narayanan R, Coss CC, Dalton JT. Development of selective androgen receptor modulators (SARMs). Mol Cell Endocrinol. 2018;465:134-142. DOI · PubMed
Research use only
For laboratory research use only. RAD-150 (TLB-150) 5mg Capsules is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
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