Description
PrymaLab · Research use only
MOTS-C 40MG
MOTS-c, the 16-residue mitochondrial-derived peptide, as a 40 mg freeze-dried fill
MOTS-c is a peptide of 16 amino acids encoded within the mitochondrial 12S rRNA gene, one of a small family of mitochondrial-derived peptides. This vial holds 40 mg of synthetic MOTS-c as white freeze-dried powder, four times the 10 mg main fill. Studies of MOTS-c have looked at muscle and fat metabolism, insulin sensitivity and physical capacity, almost all of them in mice.
Specifications
| Property | Value |
|---|---|
| Compound | MOTS-c Mitochondrial open reading frame of the 12S rRNA type-c |
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Theoretical mass | 2174.6 Da |
| Sequence / structure | H-MRWQEMGYIFYPRKLR-OH (16 residues; free N- and C-termini) |
| Label claim | 40 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-112 |
Other fills
This is the 40 mg fill. The MOTS-C 10MG page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 10 mg.
What the research covers
A 2016 review by Lee, Kim and Cohen described MOTS-c as targeting skeletal muscle and improving glucose metabolism, with possible relevance to obesity, diabetes, exercise and longevity1. In 2021 Reynolds and colleagues reported better physical performance in mice of several ages, and showed that exercise raises natural MOTS-c in human muscle and blood2. There is no human trial result among these references. The MOTS-c 10 mg vial page has the full research summary.
The MOTS-c Peptide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 40 mg vial the same peptide as the 10 mg vial?
Yes: MRWQEMGYIFYPRKLR, 16 residues, theoretical mass 2174.6 Da. The 40 mg fill is its own lot with its own certificate, shown in the panel on this page. In molar terms 40 mg is about 18.4 µmol, slightly less after the water the certificate reports.
Is a larger fill harder to keep?
Sealed, it keeps like the smaller vial: −20 °C, desiccated, dark. The difference comes after reconstitution. A 40 mg solution is likely to sit longer at 2 to 8 °C, and the methionines in MOTS-c can oxidise in solution, so the larger fill suits work that will use it promptly.
References
- Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016;100:182-187. DOI · PubMed
- Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470. DOI · PubMed
Research use only
For laboratory research use only. MOTS-C 40MG is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of MOTS-C
MOTS-C is also stocked as MOTS-C 10mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
Reviews
There are no reviews yet.