Description
PrymaLab · Research use only
Retatrutide 60mg
Sixty milligrams of retatrutide, the top fill in the range, as lyophilized powder
Retatrutide (LY3437943) is a 39-residue peptide, lipidated on one lysine, that adds glucagon receptor agonism to agonism at the GIP and GLP-1 receptors. This page lists the 60 mg vial, the largest fill PrymaLab sells, as freeze-dried powder with a dedicated lot and certificate. Much of the commentary on retatrutide compares it with tirzepatide, a dual GIP and GLP-1 agonist built on the same GIP-derived backbone.
Specifications
| Property | Value |
|---|---|
| Compound | Retatrutide LY3437943; GIP/GLP-1/glucagon receptor triple agonist |
| CAS number | 2381089-83-2 |
| Molecular formula | C221H342N46O68 |
| Theoretical mass | 4731.4 Da |
| Sequence / structure | H-Y-Aib-QGTFTSDYSI-[αMeLeu]-LDKK(AEEA-γGlu-C20 diacid)AQ-Aib-AFIEYLLEGGPSSGAPPPS-NH₂ (39 residues; Aib2, α-methyl-Leu13, Aib20; Lys17 acylated with eicosanedioic acid via γ-Glu and AEEA; C-terminal amide) |
| Label claim | 60 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-140 |
Other fills
This is the 60 mg fill. The Retatrutide 10mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, 50 mg.
What the research covers
Willard and colleagues characterised tirzepatide as an imbalanced dual agonist that engages the GIP receptor more than the GLP-1 receptor and, at the GLP-1 receptor, favours cAMP generation over β-arrestin recruitment1. Retatrutide adds glucagon receptor activity to that pair. A 2024 review dated the start of its phase 3 programme, covering diabetes, non-alcoholic fatty liver disease and obesity, to 28 August 20232. No randomised trial has compared the two molecules, and the signalling bias work has no published counterpart for retatrutide in these sources. The retatrutide 10 mg listing has the complete research section.
The Retatrutide vs Tirzepatide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
What molar quantity does a 60 mg vial hold?
Close to 12.7 µmol at 4731.4 Da, the theoretical mass on the certificate. It is an upper bound, since freeze-dried powder includes some residual water and the certificate reports how much.
Is retatrutide the same compound as tirzepatide?
No. Both are lipidated 39-residue peptides derived from the GIP sequence, but tirzepatide acts at two receptors, GIP and GLP-1, while retatrutide also activates the glucagon receptor. Their sequences differ, and retatrutide remains investigational.
References
- Willard FS, Douros JD, Gabe MB, et al. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight. 2020;5(17). DOI · PubMed
- Kaur M, Misra S. A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity. Eur J Clin Pharmacol. 2024;80(5):669-676. DOI · PubMed
Research use only
For laboratory research use only. Retatrutide 60mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Retatrutide
Retatrutide is also stocked as Retatrutide 15mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats. The retatrutide buying guide covers what to check on a certificate before ordering.
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