Description
PrymaLab · Research use only
Semax 11mg
The Semax heptapeptide MEHFPGP, a full 11 mg of freeze-dried powder per vial
Semax, Met-Glu-His-Phe-Pro-Gly-Pro, is a synthetic analogue of an ACTH fragment finished with a Pro-Gly-Pro tail. This is the larger vial: a full 11 mg of the freeze-dried heptapeptide, more than twice the 5 mg main fill, made and tested as its own lot with its own certificate. Most published research on Semax concerns neurotrophin expression in rat brain and in cultured glial cells.
Specifications
| Property | Value |
|---|---|
| Compound | Semax ACTH(4–7)-Pro-Gly-Pro heptapeptide (MEHFPGP) |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Theoretical mass | 813.9 Da |
| Sequence / structure | H-MEHFPGP-OH (7 residues; free N- and C-termini) |
| Label claim | 11 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-147 |
Other fills
This is the 11 mg fill. The Semax 5mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 5 mg.
What the research covers
In rats, a single application of Semax raised hippocampal BDNF protein up to 1.4-fold and increased phosphorylation of its receptor trkB1. Tritium-labelled Semax was detectable in rat brain two minutes after nasal application but was broken down fast, mostly to the tripeptide Pro-Gly-Pro2. Both studies are from Russian groups, and neither tested PrymaLab material. The Semax 5 mg vial page has the full research summary, including the glial cell work and what remains unknown.
The Semax vs Selank guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. The one outside report on file is a Janoshik Analytical test of Semax 11 mg, batch 001 (task 96920, 99.39% purity), which can be checked on Janoshik’s verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 11 mg vial the same peptide as the 5 mg?
Yes. Both contain H-MEHFPGP-OH with a theoretical mass of 813.9 Da. This fill holds a full 11 mg of peptide, about 13.5 µmol, and is made and tested as a separate lot whose certificate appears in the panel on this page.
Does a larger vial change how Semax is stored?
Not while sealed: −20 °C, desiccated and dark. The methionine at position 1 is the reason to limit air, moisture and light once the vial is open. A larger fill tends to mean solution held longer at 2 to 8 °C, so open it when the work needs that much material.
References
- Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60. DOI · PubMed
- Shevchenko KV, Nagaev IIu, Alfeeva LIu, et al. [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration]. Bioorg Khim. 2006;32(1):64-70. DOI · PubMed
Research use only
For laboratory research use only. Semax 11mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Semax
Semax is also stocked as Semax 1mg/ml preloaded 3ml pen and Semax 10mg Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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