Description
PrymaLab · Research use only
Retatrutide 5mg
The smallest retatrutide fill: 5 mg of lyophilized LY3437943 in one vial
Retatrutide, coded LY3437943 in the early papers, is a lipidated peptide designed to act on the GIP, GLP-1 and glucagon receptors together. The 5 mg vial is the smallest fill in the range and holds white lyophilized powder under its own lot number. Published work covers how the molecule was designed, its receptor activity, mouse studies and clinical trials in obesity, diabetes and liver fat, all with an investigational drug.
Specifications
| Property | Value |
|---|---|
| Compound | Retatrutide LY3437943; GIP/GLP-1/glucagon receptor triple agonist |
| CAS number | 2381089-83-2 |
| Molecular formula | C221H342N46O68 |
| Theoretical mass | 4731.4 Da |
| Sequence / structure | H-Y-Aib-QGTFTSDYSI-[αMeLeu]-LDKK(AEEA-γGlu-C20 diacid)AQ-Aib-AFIEYLLEGGPSSGAPPPS-NH₂ (39 residues; Aib2, α-methyl-Leu13, Aib20; Lys17 acylated with eicosanedioic acid via γ-Glu and AEEA; C-terminal amide) |
| Label claim | 5 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-140 |
Other fills
This is the 5 mg fill. The Retatrutide 10mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg.
What the research covers
The discovery paper by Coskun and colleagues reported that LY3437943 activates the GLP-1 and glucagon receptors to a similar degree and the GIP receptor more strongly1. In obese mice it lowered body weight and improved glycaemic control, and the authors credited part of the weight effect to higher energy expenditure through the glucagon receptor1. They judged that these results, with an early phase 1 study, warranted further clinical work1. The phase 2 trials and the open questions are summarised on the retatrutide 10 mg page.
The Retatrutide vs Tirzepatide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How much retatrutide is in a 5 mg vial in molar terms?
About 1.06 µmol, using the theoretical mass of 4731.4 Da given on the certificate. The real figure is a little lower because freeze-dried powder holds some residual water, which the certificate reports as a percentage for each lot.
Is the 5 mg fill tested separately from the larger vials?
Yes. Each fill is produced and released as its own lot. The 5 mg vial has a separate lot number and certificate, and the panel on this page shows the results for the 5 mg lot currently shipping.
References
- Coskun T, Urva S, Roell WC, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. 2022;34(9):1234-1247.e9. DOI · PubMed
Research use only
For laboratory research use only. Retatrutide 5mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Retatrutide
Retatrutide is also stocked as Retatrutide 15mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats. The retatrutide buying guide covers what to check on a certificate before ordering.
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