Description
PrymaLab · Research use only
Semax 10mg Nasal Spray
The Semax heptapeptide in bacteriostatic water, 10 mg in a metered spray bottle
Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, made by joining residues 4 to 7 of ACTH to a Pro-Gly-Pro tail. This listing is the nasal spray: 10 mg of Semax dissolved in preserved bacteriostatic water and supplied in a metered spray bottle. The nasal route runs through the Semax animal literature, which covers neurotrophin expression in the rat brain and how much labelled peptide reaches brain tissue.
Specifications
| Property | Value |
|---|---|
| Compound | Semax ACTH(4–7)-Pro-Gly-Pro heptapeptide (MEHFPGP) |
| CAS number | 80714-61-0 |
| Molecular formula | C37H51N9O10S |
| Theoretical mass | 813.9 Da |
| Sequence / structure | H-MEHFPGP-OH (7 residues; free N- and C-termini) |
| Contents | Semax: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-149 |
What is in the bottle
Each bottle contains 10 mg of Semax as a sterile solution in bacteriostatic water with 0.9% benzyl alcohol as preservative. The safety data sheet gives the peptide concentration as 0.1% w/v or less. The peptide is the same H-MEHFPGP-OH sold freeze-dried in the vials, with a theoretical mass of 813.9 Da. Semax itself is not classified as hazardous; benzyl alcohol carries warnings for harm if swallowed or inhaled, serious eye irritation and skin sensitisation.
Store the bottle upright and capped at 2 to 8 °C, away from light, and never freeze it. Semax begins with a methionine that can oxidise, so a solution is best kept cold and closed. The reasoning behind cold, dark storage for peptides in solution is covered in peptide storage and stability.
Spray, pen or vial
The same peptide is sold in four listings. The Semax 5 mg vial and the 11 mg vial hold freeze-dried powder, kept at −20 °C until the laboratory dissolves it at whatever concentration the work needs. The Semax preloaded pen holds 3 mg at a fixed 1 mg/mL. The spray holds the most peptide of the solution formats, 10 mg, in a bottle with a metered pump. Every format is made from peptide lots tested in PrymaLab’s own laboratory; for the pen and the spray, the certificate describes the peptide lot, not the finished liquid.
What the research covers
Semax and the nasal route in rats
The group behind most Semax work describes the peptide as having marked effects on learning and neuroprotective activity after intranasal application1. In their 2006 study a single application to rats raised hippocampal BDNF protein to as much as 1.4 times control and trkB phosphorylation 1.6-fold1. Shevchenko and colleagues tracked tritium-labelled Semax after nasal application in rats. Two minutes later the brain held 0.093% of the total radioactivity per gram, 80% of it still intact Semax, and degradation was fast, with Pro-Gly-Pro the dominant product2.
Nose to brain in general
Lochhead and Thorne reviewed the nasal anatomy and the pathways that may carry molecules from the nasal epithelium to the central nervous system, a possible way around the blood-brain barrier, drawing on preclinical and clinical studies of large biologics3. Semax is far smaller than the proteins that review centres on, so its findings set out the routes that exist, not how well Semax uses them.
What is not established
The labelled-peptide study shows that a small fraction of intact Semax reached rat brain within minutes and was then broken down quickly. It does not give a delivery figure for any spray device or for species other than the rat. None of the references used a preserved spray like this one or measured Semax stability in solution, and the work comes from a small number of Russian groups. The Semax vs Selank guide covers the full literature.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. The one outside report on file is a Janoshik Analytical test of Semax 11 mg, batch 001 (task 96920, 99.39% purity), which can be checked on Janoshik’s verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same Semax as the vials?
Yes, the same H-MEHFPGP-OH heptapeptide with a theoretical mass of 813.9 Da. The vials hold it as freeze-dried powder stored at −20 °C. The spray holds 10 mg already dissolved in bacteriostatic water, stored at 2 to 8 °C and never frozen.
How much Semax is in one bottle?
10 mg per bottle, at a concentration of 0.1% w/v or less according to the safety data sheet. Where a study needs a concentration chosen by the researcher, the 5 mg and 11 mg vials supply a stated mass of dry peptide instead.
Has Semax been studied by the nasal route?
In rats. A tritium-labelled study measured how much Semax reached the brain after nasal application, and the group behind the hippocampal BDNF work describes its effects after intranasal application. Both are Russian studies, and neither used a preserved spray or measured Semax stability in solution.
What does the certificate cover for the spray?
It covers the Semax peptide lot used to fill the bottles, not the finished solution. The testing section on this page explains what each certificate reports and how to confirm a certificate by its number and key.
Is the spray for human use?
No. It is sold for laboratory research only, is not approved by the FDA for human or veterinary use, and must not be given to people or animals. It carries no instructions for use in a person.
References
- Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60. DOI · PubMed
- Shevchenko KV, Nagaev IIu, Alfeeva LIu, et al. [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration]. Bioorg Khim. 2006;32(1):64-70. DOI · PubMed
- Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev. 2012;64(7):614-28. DOI · PubMed
Research use only
For laboratory research use only. Semax 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Semax
Semax is also stocked as Semax 11mg. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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