Description
PrymaLab · Research use only
Selank 10mg Nasal Spray
Selank (TKPRPGP) in bacteriostatic water, 10 mg in a metered spray bottle
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, made by adding a Pro-Gly-Pro tail to tuftsin, a four-residue immune peptide. Here it is sold as a nasal spray, with 10 mg of Selank in preserved bacteriostatic water filling a metered spray bottle. Selank research, much of it from Russian groups, covers neurotransmission genes in the rat brain and behaviour in rodent stress models, while a separate literature asks whether molecules can travel from the nose to the brain.
Specifications
| Property | Value |
|---|---|
| Compound | Selank Tuftsin-Pro-Gly-Pro heptapeptide (TKPRPGP) |
| CAS number | 129954-34-3 |
| Molecular formula | C33H57N11O9 |
| Theoretical mass | 751.9 Da |
| Sequence / structure | H-TKPRPGP-OH (7 residues; free N- and C-termini) |
| Contents | Selank: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-145 |
What is in the bottle
The bottle holds 10 mg of Selank as a sterile solution in bacteriostatic water with 0.9% benzyl alcohol as preservative. The safety data sheet puts the peptide at 0.1% w/v or less. It is the same H-TKPRPGP-OH as the freeze-dried vials, theoretical mass 751.9 Da. The safety data sheet leaves the peptide unclassified and lists the preservative, benzyl alcohol, as harmful if swallowed or inhaled, an eye irritant and a skin sensitiser.
Refrigerate the bottle at 2 to 8 °C, upright, capped and in the dark, and do not let it freeze. Selank’s sequence has no methionine or cysteine, which spares it the oxidation that complicates Semax in solution, but the storage terms on the safety data sheet still apply. The general principles are covered in peptide storage and stability.
What the research covers
What the Selank studies measured
In the rat frontal cortex, Volkova and colleagues profiled 84 genes involved in neurotransmission one and three hours after Selank or GABA. Real-time PCR picked up significant changes in 45 genes at the first time point and 22 at the second, and the Selank and GABA patterns correlated1. Earlier, Kozlovskaya and colleagues had compared Selank with ten other tuftsin-family peptides in rats and mice sorted by emotional reactivity and exposed to a conflict situation; they reported antistress effects that differed with each peptide’s structure and its breakdown fragments2.
The nasal route
Illum reviewed the case for direct transport from nose to brain along the olfactory pathway. Many animal studies, mostly in rats, reported nose-to-brain delivery of a range of drugs, and studies in volunteers that sampled cerebrospinal fluid and blood were, in the author’s view, confirming that a direct pathway likely exists3. That review concerns drugs in general, not Selank.
What is not established
Neither Selank abstract cited here states the route used, and none of the references measured how much Selank crosses the nasal lining or reaches the brain from a spray. No study here used a preserved solution like this one. The Semax vs Selank guide covers the Selank literature in full, and the brain and cognition research overview sets it among related peptides.
The Selank Peptide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same Selank as the vials?
It is. Both contain H-TKPRPGP-OH, theoretical mass 751.9 Da. The difference is form: dry powder stored frozen in the vials, against 10 mg in refrigerated bacteriostatic water in the spray, which should never be frozen.
How much Selank does the bottle contain?
Ten milligrams, about 13.3 µmol, with the concentration at or below 0.1% w/v on the safety data sheet. If a study has to set its own concentration, the freeze-dried 5 mg and 11 mg vials suit that better because they state a dry mass.
Has Selank been studied as a nasal spray?
Not in the papers cited on this page. The Selank abstracts here do not state a route, and the nose-to-brain review covers drugs in general. There are no published findings among these references on Selank uptake from a spray.
What does the certificate cover for the spray?
The lot certificate applies to the Selank used to fill the bottles; the solution itself is not separately certified. The testing section on this page summarises what a certificate contains and how to verify it.
Is the spray for human use?
No. The spray is laboratory research material only. It has no FDA approval for human or veterinary use and must not be given to people or animals, and this page gives no directions for using it in a person.
References
- Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31. DOI · PubMed
- Kozlovskaya MM, Kozlovskii II, Val'dman EA, et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33(9):853-60. DOI · PubMed
- Illum L. Is nose-to-brain transport of drugs in man a reality?. J Pharm Pharmacol. 2004;56(1):3-17. DOI · PubMed
Research use only
For laboratory research use only. Selank 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Selank
Selank is also stocked as Selank 1mg/ml preloaded 3ml pen, Selank 5mg and Selank 11mg. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
4 reviews for Selank 10mg Nasal Spray