Description
PrymaLab · Research use only
GHK-CU 50MG
The Gly-His-Lys copper(II) complex in a 50 mg vial of freeze-dried powder
GHK-Cu, the copper(II) complex of the plasma tripeptide Gly-His-Lys, is sold here as a 50 mg vial, half the main 100 mg fill. The powder is blue because of the bound copper. Most studies of the complex measured collagen and matrix enzymes in fibroblast cultures; wound and skin work is known mainly through reviews.
Specifications
| Property | Value |
|---|---|
| Compound | GHK-Cu Copper tripeptide-1; Gly-His-Lys · Cu(II) |
| CAS number | 89030-95-5 |
| Molecular formula | C14H22CuN6O4 |
| Theoretical mass | 401.9 Da |
| Sequence / structure | H-GHK-OH · Cu(II) (1:1 complex; copper bound by the Gly α-amine, the Gly–His amide nitrogen and the His imidazole) |
| Label claim | 50 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-058 |
Other fills
This is the 50 mg fill. The GHK-CU 100MG page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 100 mg.
What the research covers
In the first fibroblast study of the complex, collagen production climbed from picomolar concentrations and peaked at 1 nanomolar1. A review by Pickart and colleagues later described GHK as adjusting both the build-up and the breakdown of collagen and glycosaminoglycans, and as attracting immune and endothelial cells to injured tissue2. Almost all of this rests on cell culture and animal work. The GHK-Cu 100 mg vial page carries the full research summary, including the matrix enzyme and gene expression findings.
The GHK-Cu Peptide (Copper Peptide) guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 50 mg vial the same compound as the 100 mg vial?
Yes. Both contain the 1:1 complex of Gly-His-Lys with copper(II), theoretical mass 401.9 Da, as blue freeze-dried powder. The 50 mg fill is produced and tested as its own lot, with its own lot number and certificate.
How much GHK-Cu is 50 mg in molar terms?
About 124 µmol, from the certificate's theoretical mass of 401.9 Da. The true figure is slightly lower because the powder also holds a little water, which the certificate reports as a percentage.
Does a smaller fill change how the vial is stored?
No. The sealed vial goes at −20 °C, dry and dark, and reconstituted solution at 2 to 8 °C away from light. The smaller fill just means less solution waiting in the refrigerator between experiments.
References
- Maquart FX, Pickart L, Laurent M, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238(2):343-6. DOI · PubMed
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108. DOI · PubMed
Research use only
For laboratory research use only. GHK-CU 50MG is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of GHK-CU
GHK-CU is also stocked as GHK-Cu Nasal Spray and GHK-CU 50mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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