RAD-140 (Testolone) 10mg Capsules

Description

What Is RAD-140 (Testolone)?

RAD-140, commonly known as testolone, is a non-steroidal selective androgen receptor modulator (SARM) developed by Radius Health, Inc. for the investigational treatment of muscle wasting conditions and hormone receptor-positive breast cancer. RAD-140 selectively binds to androgen receptors in skeletal muscle and bone tissue with high affinity while demonstrating minimal androgenic activity in prostate and seminal vesicle tissues.

Testolone exhibits an anabolic-to-androgenic ratio of approximately 90:1, making it one of the most tissue-selective SARMs characterized in preclinical research. Published pharmacokinetic data demonstrate oral bioavailability exceeding 60 percent, with a plasma half-life of approximately 60 hours in primates. This extended half-life and oral dosing route distinguish RAD-140 from traditional anabolic agents that require frequent injection and carry systemic androgenic side effect profiles. The compound entered Phase I clinical trials for breast cancer in 2017, further validating its pharmacological profile.

Key Features and Specifications

Mechanism of Action: How RAD-140 Works

RAD-140 functions as a full agonist at androgen receptors in muscle and bone tissue while acting as an antagonist or partial agonist in androgenic tissues such as the prostate. This tissue selectivity arises from differential cofactor recruitment at the androgen receptor, meaning RAD-140 activates distinct transcriptional programs depending on the cell type. In myocytes and osteoblasts, testolone recruits coactivator proteins that drive anabolic gene expression, promoting protein synthesis and nitrogen retention.

Preclinical studies in cynomolgus monkeys demonstrated that RAD-140 at 0.1 mg/kg produced a mean body weight gain of over 10 percent in 28 days, with simultaneous reduction in LDL cholesterol and triglycerides. The compound also exhibited neuroprotective properties in cell culture models, reducing kainate-induced neurotoxicity and amyloid-beta-induced cell death, suggesting potential applications in neurodegenerative disease research.

Importantly, RAD-140 does not undergo aromatization to estrogen, eliminating estrogen-related side effects common to traditional anabolic compounds. Its selectivity index in preclinical assays exceeds that of many other SARMs, positioning testolone as one of the most researched compounds in its class.

Reported Research Applications and Benefits

Lean mass accretion research represents the primary application for RAD-140. Preclinical data consistently show dose-dependent increases in skeletal muscle mass without proportional increases in prostate weight, confirming the tissue-selective mechanism. Researchers investigating sarcopenia, cachexia, and muscle wasting conditions have utilized testolone to evaluate anabolic interventions that spare androgenic tissues.

Bone density studies indicate that RAD-140 activates androgen receptors in osteoblasts, stimulating bone mineralization pathways and increasing cortical bone thickness. These properties have attracted interest from researchers studying osteoporosis and age-related bone loss, particularly in combination protocols with other osteogenic agents.

Neuroprotection research has emerged as a significant application area following the discovery that RAD-140 protects hippocampal neurons against amyloid-beta and kainate-induced toxicity through androgen receptor-mediated pathways. Body composition optimization studies have documented reductions in fat mass concurrent with lean mass gains, consistent with the metabolic effects of enhanced androgen receptor signaling in skeletal muscle.

RAD-140 Dosage Information for Research

RAD-140 is typically administered once daily in the morning due to its extended plasma half-life. Research protocols commonly include baseline and endpoint blood panels to monitor hormone levels, as testolone can suppress endogenous testosterone production in a dose-dependent manner. Post-cycle protocols with SERMs are frequently incorporated into research designs lasting beyond eight weeks.

RAD-140 vs RAD-150: Key Differences

Storage and Handling Instructions

Store RAD-140 capsules at controlled room temperature between 20°C and 25°C (68°F to 77°F) in the original sealed container. Protect from direct sunlight, excessive heat, and humidity. Keep capsules in their original packaging until use. Under recommended storage conditions, RAD-140 capsules maintain full potency for at least 24 months from the date of manufacture. Do not freeze or expose to temperatures above 30°C.

Why Choose PrymaLab RAD-140 Testolone Capsules

Every batch of PrymaLab RAD-140 undergoes comprehensive third-party analysis by independent, accredited laboratories using high-performance liquid chromatography (HPLC) for purity determination and mass spectrometry (MS) for identity confirmation. Each order includes a batch-specific Certificate of Analysis (COA) documenting ≥99% purity, absence of heavy metals, residual solvents, and microbial contaminants.

PrymaLab employs pharmaceutical-grade encapsulation to deliver precise 10 mg dosing per capsule, providing the reproducibility that controlled research protocols demand. Full lot traceability, GMP-compliant manufacturing, and free priority shipping on all domestic orders ensure a seamless research supply chain from lab to bench.

Frequently Asked Questions About RAD-140

What is the best time to take RAD-140 for research purposes?

Most research protocols administer RAD-140 once daily in the morning. The extended plasma half-life of approximately 60 hours in primates ensures stable circulating concentrations throughout the dosing interval, making precise timing less critical than with shorter-acting compounds. Consistent daily administration at the same time optimizes pharmacokinetic stability.

Does RAD-140 require post-cycle therapy in research protocols?

Research protocols lasting eight weeks or longer at doses of 10 mg per day or above frequently incorporate post-cycle therapy using selective estrogen receptor modulators such as enclomiphene or clomiphene. RAD-140 can suppress endogenous testosterone production in a dose- and duration-dependent manner, and PCT protocols help restore hormonal homeostasis after cessation.

How does RAD-140 differ from traditional anabolic steroids?

RAD-140 is a non-steroidal selective androgen receptor modulator with a 90:1 anabolic-to-androgenic ratio, meaning it preferentially activates androgen receptors in muscle and bone while sparing prostate and other androgenic tissues. Traditional anabolic steroids lack this tissue selectivity and can undergo aromatization to estrogen. RAD-140 does not aromatize.

What purity level should researchers expect from quality RAD-140?

Research-grade RAD-140 should test at ≥99% purity by HPLC analysis. Each PrymaLab batch is independently verified by third-party laboratories and ships with a Certificate of Analysis documenting purity, identity confirmation by mass spectrometry, and absence of contaminants including heavy metals and residual solvents.

Can RAD-140 be stacked with other SARMs in research?

Published research protocols have investigated RAD-140 in combination with GW-501516 (cardarine) for body composition studies and with MK-677 (ibutamoren) for anabolic and GH secretagogue synergy. Combination protocols require careful dose management and comprehensive blood panel monitoring to assess cumulative effects on hormonal parameters.

Quality Assurance and Testing

PrymaLab maintains rigorous quality control standards for all RAD-140 products. Each batch undergoes HPLC purity analysis, mass spectrometry identity confirmation, heavy metal screening (arsenic, cadmium, lead, mercury), residual solvent testing, and microbial contamination assessment. All testing is conducted by independent, accredited third-party laboratories, and results are documented in batch-specific Certificates of Analysis available with every order. Our quality program ensures pharmaceutical research-grade consistency from synthesis through final packaging.

Research Disclaimer

RAD-140 (testolone) is sold strictly for laboratory research and scientific investigation purposes only. This product is not intended for human consumption, veterinary use, or therapeutic application. RAD-140 has not been approved by the FDA or any regulatory agency for medical use. Purchasers must be qualified researchers affiliated with accredited institutions or licensed research organizations. By purchasing this product, you confirm that it will be used exclusively in accordance with all applicable local, state, and federal regulations governing research materials.