Description
PrymaLab · Research use only
TB-500 (Thymosin Beta-4) 10mg
Full-length N-acetyl thymosin beta-4 in a 10 mg freeze-dried fill
Thymosin beta-4, sold here as TB-500, is a 43-residue peptide that binds actin monomers inside cells. This vial holds 10 mg of the complete N-acetylated chain as freeze-dried powder, twice the 5 mg main fill, with its own lot number and certificate. Most studies of the peptide concern the actin cytoskeleton and tissue repair in animal and cell models.
Specifications
| Property | Value |
|---|---|
| Compound | TB-500 (Thymosin β4) N-acetyl thymosin β4, full-length 43-residue peptide |
| CAS number | 77591-33-4 |
| Molecular formula | C212H350N56O78S |
| Theoretical mass | 4963.5 Da |
| Sequence / structure | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-OH (43 residues; N-acetyl; free C-terminus) |
| Label claim | 10 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-159 |
Other fills
This is the 10 mg fill. The TB-500 (Thymosin Beta-4) 5mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 5 mg.
What the research covers
Thymosin beta-4 forms a one-to-one complex with G-actin, giving the cell a reserve of monomers that cannot polymerise until released1. A 2012 review linked it to stem and progenitor cell migration, new blood vessel formation and less scarring in wounds, and listed clinical trials as ongoing or planned2. How it acts outside the cell was still unknown in 20011. The TB-500 5 mg vial page has the full research summary.
The TB-500 Peptide (Thymosin Beta-4) guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 10 mg vial the same peptide as the 5 mg vial?
Yes: the same N-acetyl thymosin beta-4, 43 residues, theoretical mass 4963.5 Da. The 10 mg fill is made and tested as a separate lot, so it has its own lot number and certificate.
What changes when reconstituting 10 mg instead of 5 mg?
Only the arithmetic. The same volume of bacteriostatic water gives twice the concentration, so 2 mL makes 5 mg/mL instead of 2.5. In molar terms 10 mg is about 2.0 µmol, slightly less once the certificate's water content is allowed for.
Is a larger fill harder to store?
Sealed, it is kept like the 5 mg vial: −20 °C, desiccated and dark. After reconstitution a bigger fill usually means a solution held longer at 2 to 8 °C, so size the volume to how quickly it will be used.
References
- Huff T, Müller CS, Otto AM, et al. beta-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol. 2001;33(3):205-20. DOI · PubMed
- Goldstein AL, Hannappel E, Sosne G, et al. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. DOI · PubMed
Research use only
For laboratory research use only. TB-500 (Thymosin Beta-4) 10mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of TB-500
TB-500 is also stocked as TB-500 5mg/ml preloaded 3ml pen, TB-500 Peptide Nasal Spray, BPC-157 + TB500 (10mg/10mg) "Wolverine Blend", BPC-157 Capsules (60/500mcg), BPC-157 Peptide Nasal Spray, BPC 157 5mg + TB500 5mg and BPC-157 5mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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