Description
PrymaLab · Research use only
AOD9604 10mg Nasal Spray
AOD-9604 as a sterile solution, 10 mg in a metered nasal spray bottle
AOD-9604 is a modified C-terminal fragment of human growth hormone, sixteen residues long: hormone residues 177 to 191 with a tyrosine added at the N-terminus, and one disulfide ring. This listing supplies 10 mg of it as a sterile solution in bacteriostatic water, in a metered nasal spray bottle. Published work on AOD-9604 concerns fat metabolism and glucose control in obese rodents, and none of the studies cited here looked at the nasal route.
Specifications
| Property | Value |
|---|---|
| Compound | AOD-9604 Tyr-hGH(177–191); lipolytic C-terminal fragment of human growth hormone |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Theoretical mass | 1815.1 Da |
| Sequence / structure | H-YLRIVQCRSVEGSCGF-OH (16 residues; Cys7–Cys14 disulfide; free N- and C-termini) |
| Contents | AOD-9604: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-014 |
What is in the bottle
The bottle holds 10 mg of AOD-9604 dissolved in bacteriostatic water with 0.9% benzyl alcohol as a preservative. The safety data sheet puts the peptide at no more than 0.1% w/v, and the label states the exact concentration. Benzyl alcohol carries hazard statements for harm if swallowed or inhaled, serious eye irritation and skin sensitisation, while the peptide is not classified. Store the bottle upright and capped at 2 to 8 °C, away from light, and do not freeze it. General guidance on peptide solutions is in peptide storage and stability. The same peptide is sold freeze-dried in the AOD-9604 5 mg vial.
What the research covers
The C-terminal region of growth hormone was first studied as a source of metabolic activity in the 1970s. In normal rats, Ng and Bornstein found that synthetic fragments ending at residue 191 and starting at 172, 176, 177 or 178 produced a brief rise in blood glucose and a longer rise in insulin, and they concluded that active peptides needed the right physical configuration as well as the minimum sequence1. AOD-9604 came later, presented by Ng and colleagues as a synthetic version of growth hormone’s lipolytic domain2. Over 19 days of oral treatment, obese Zucker rats gained less than half the weight of controls and showed more lipolytic activity in adipose tissue, with no adverse effect on insulin sensitivity, in contrast to chronic treatment with intact growth hormone2.
AOD-9604 keeps its two cysteines in a disulfide ring. Hogg reviewed evidence that some disulfide bonds work as switches, with cleavage changing what a secreted protein or receptor does3. None of the AOD-9604 papers cited here compared the closed ring with an open form, so it is not known whether the ring is needed for activity.
No reference here studied AOD-9604 delivered through the nose or measured how a 1815.1 Da peptide behaves on the nasal lining. The AOD-9604 guide has the full literature, and the HGH fragment 176-191 guide explains how the two related peptides differ.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How much AOD-9604 is in the bottle?
10 mg, according to the safety data sheet, at no more than 0.1% w/v; the label on the bottle gives the exact concentration. Where a study calls for a concentration chosen in the lab, the 5 mg vial supplies dry peptide of stated mass instead.
Has AOD-9604 been studied as a nasal spray?
Not in the papers cited on this page. The rodent studies gave the peptide by mouth or through implanted pumps, and the developer's human trials used tablets, so there are no published nasal findings to point to.
Why keep the spray cold and upright?
Those are the safety data sheet conditions: 2 to 8 °C, out of the light, upright, capped and never frozen. The certificate covers the peptide lot used to fill the bottle rather than the finished solution, so storage is the main control on the solution's condition.
Is the spray for human use?
No. AOD-9604 nasal spray is sold for laboratory research only and has no approval for human or veterinary use. It must not be given to people or animals, and nothing on this page describes a clinical use.
References
- Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978;234(5):E521-6. DOI · PubMed
- Ng FM, Sun J, Sharma L, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. DOI · PubMed
- Hogg PJ. Disulfide bonds as switches for protein function. Trends Biochem Sci. 2003;28(4):210-4. DOI · PubMed
Research use only
For laboratory research use only. AOD9604 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of AOD9604
AOD9604 is also stocked as AOD-9604 6mg preloaded 3ml pen and HGH Fragment 176-191 10mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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