Description
PrymaLab · Research use only
Preloaded Autoinjector | AOD-9604 | 3ml Pen | 6mg
AOD-9604 in bacteriostatic water at 2 mg/mL, 6 mg in a preloaded 3 mL pen
AOD-9604 is a synthetic growth hormone fragment: hormone residues 177 to 191 led by an added tyrosine and closed by a single disulfide. Here it comes ready dissolved, in a preloaded autoinjector pen with 6 mg of peptide in 3 mL of bacteriostatic water, so there is no powder to handle. Published research on AOD-9604 has dealt with fat metabolism, blood glucose and growth hormone receptor binding in rodents and cell lines.
Specifications
| Property | Value |
|---|---|
| Compound | AOD-9604 Tyr-hGH(177–191); lipolytic C-terminal fragment of human growth hormone |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Theoretical mass | 1815.1 Da |
| Sequence / structure | H-YLRIVQCRSVEGSCGF-OH (16 residues; Cys7–Cys14 disulfide; free N- and C-termini) |
| Contents | AOD-9604: 6 mg per 3 mL pen (0.2% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-013 |
What is in the pen
The cartridge holds 3 mL of sterile solution with AOD-9604 at 0.2% w/v, which is 2 mg/mL and 6 mg per pen. At the certificate’s theoretical mass of 1815.1 Da that comes to about 1.1 mM, or 3.3 µmol in the whole pen. The solvent is bacteriostatic water with 0.9% benzyl alcohol. The safety data sheet does not classify the peptide; benzyl alcohol is listed as harmful if swallowed or inhaled, irritating to the eyes and a possible skin sensitiser. Keep the pen in its carton at 2 to 8 °C, protected from light and capped between uses, and never freeze it. A pen whose solution has frozen, changed colour or gone cloudy should be discarded. Laboratories that want to set their own concentration can use the AOD-9604 5 mg vial, which holds the same peptide freeze-dried; peptide pen vs vial compares the two formats in general.
What the research covers
AOD-9604 traces back to the finding that the C-terminal end of growth hormone has metabolic activity of its own. In 1978 Ng and Bornstein reported that synthetic fragments covering hormone residues 172-191 through 178-191 briefly raised blood glucose, and raised plasma insulin for longer, in normal rats, while the shorter 179-191 and 180-191 did nothing1. The later analogue was studied in obese animals. In a 14-day study using osmotic pumps in obese and lean mice, Heffernan and colleagues recorded lower body weight gain in the obese animals, more fat oxidation and higher plasma glycerol, with none of the hyperglycaemia or loss of insulin secretion that growth hormone produced2. The same paper found that AOD-9604 neither competed for the growth hormone receptor nor made receptor-bearing cells proliferate2. A companion study in beta-3 adrenergic receptor knockout mice concluded that its action on lipolysis did not run directly through that receptor3.
All of this is rodent and cell work, and none of it involved a peptide stored in solution. The AOD-9604 guide sets out the full literature, and the HGH fragment 176-191 guide covers the developer’s human studies, which used tablets, and how the native fragment differs from this peptide.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How does the pen differ from the AOD-9604 vial?
The vial holds 5 mg of freeze-dried peptide that is kept at −20 °C until a laboratory dissolves it. The pen holds 6 mg already in bacteriostatic water at 2 mg/mL and is kept at 2 to 8 °C. Both contain the same tyrosine-led, disulfide-bridged sequence.
Is the pen HGH fragment 176-191?
No. It contains AOD-9604, whose first residue is tyrosine. The native fragment 176-191 has phenylalanine in that position and is a separate compound with its own CAS number, which PrymaLab sells in a different pen under its own name.
What does the certificate cover for the pen?
The peptide lot used to fill it. That certificate reports purity by HPLC, identity by LC-MS, water, endotoxin and sterility for the lot; it does not describe the finished solution in the cartridge, so the storage conditions on the safety data sheet matter.
Is the pen meant for human use?
No. It is a laboratory research product, not approved for human or veterinary use by the FDA or any comparable regulator, and must not be given to people or animals.
References
- Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978;234(5):E521-6. DOI · PubMed
- Heffernan MA, Thorburn AW, Fam B, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-9. DOI · PubMed
- Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-9. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of AOD-9604
AOD-9604 is also stocked as AOD9604 10mg Nasal Spray and HGH Fragment 176-191 10mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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