Description
PrymaLab · Research use only
Kisspeptin-10 10mg Nasal Spray
Kisspeptin-10 nasal spray: the amidated decapeptide in solution, 10 mg per bottle
Kisspeptin-10 (KP-10) is the ten-residue C-terminal fragment of human kisspeptin, YNWNSFGLRF-NH2, and an agonist at the kisspeptin receptor. In this listing it comes as a sterile solution in bacteriostatic water, 10 mg in a metered spray bottle. Kisspeptin research covers the receptor, its control of GnRH and gonadotropin release, and human studies that used other routes; none of the work cited here tested a nasal spray.
Specifications
| Property | Value |
|---|---|
| Compound | Kisspeptin-10 KP-10; human metastin 45–54 |
| CAS number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Theoretical mass | 1302.4 Da |
| Sequence / structure | H-YNWNSFGLRF-NH₂ (10 residues; C-terminal amide) |
| Contents | Kisspeptin-10: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-094 |
What is in the bottle
The bottle contains kisspeptin-10 dissolved in bacteriostatic water, with 0.9% benzyl alcohol as the preservative. The safety data sheet gives 10 mg of peptide per bottle at no more than 0.1% w/v, and the bottle label states the concentration. The peptide is the same H-YNWNSFGLRF-NH2 as in the kisspeptin-10 5 mg vial, with a theoretical mass of 1302.4 Da. Kisspeptin-10 carries no hazard classification on the SDS; benzyl alcohol is listed as harmful if swallowed or inhaled, a serious eye irritant and a skin sensitiser.
Keep the bottle upright and capped at 2 to 8 °C, protected from light, and never let it freeze. The peptide storage and stability article covers why peptides in solution need colder, darker conditions than dry powder.
What the research covers
Kisspeptin was first isolated from human placenta as metastin, a 54-residue peptide with an amidated C-terminus, encoded by the KiSS-1 metastasis suppressor gene and recognised by an orphan receptor then called hOT7T1751. In that 2001 paper metastin inhibited chemotaxis and invasion of receptor-transfected CHO cells and reduced lung metastasis of receptor-transfected B16-BL6 melanoma cells in vivo1. Kisspeptin-10 is the last ten residues of that peptide.
The short fragment does not last long in circulation. In male mice its half-life in the bloodstream was about 4 minutes, against about 32 minutes for kisspeptin-54, and it sustained LH release for a much shorter time2. In men, kisspeptin-54 had a plasma half-life of 27.6 minutes in a small double-blind, placebo-controlled crossover study with intravenous infusion that measured LH, FSH and testosterone3.
No paper cited here delivered kisspeptin-10 through the nose, so how much crosses the nasal lining, and whether it survives long enough to reach its receptor, is not established. General evidence on the route is in the overview of peptide nasal sprays, and the receptor and cell work is in the kisspeptin-10 (kisspeptin 45-54) guide.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same peptide as the kisspeptin-10 vials?
Yes. All of them hold kisspeptin-10, H-YNWNSFGLRF-NH2, CAS 374675-21-5. The vials contain freeze-dried powder stored at −20 °C; the spray contains 10 mg already dissolved in bacteriostatic water and is stored at 2 to 8 °C, never frozen.
Has kisspeptin-10 been studied as a nasal spray?
Not in any paper cited on this page. The human studies here used intravenous and other non-nasal routes, and the mouse data show kisspeptin-10 clears from the blood within minutes. There are no published findings for this format to point to.
What does the certificate cover for the spray?
The certificate is for the kisspeptin-10 lot that filled the bottle, tested in PrymaLab's own laboratory; the solution itself is not separately tested. The testing section on this page says where certificates are published and how to verify one.
Can the spray be used in people?
No. The spray is sold for laboratory research only. Kisspeptin-10 is not approved for human or veterinary use by the FDA or any other authority, and this bottle must not be given to people or animals.
References
- Ohtaki T, Shintani Y, Honda S, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411(6837):613-7. DOI · PubMed
- d'Anglemont de Tassigny X, Jayasena CN, Murphy KG, et al. Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. PLoS One. 2017;12(5):e0176821. DOI · PubMed
- Dhillo WS, Chaudhri OB, Patterson M, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-15. DOI · PubMed
Research use only
For laboratory research use only. Kisspeptin-10 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Kisspeptin-10
Kisspeptin-10 is also stocked as KissPeptin-10 (10mg) and Kisspeptin-10 10mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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