Description
PrymaLab · Research use only
Preloaded Autoinjector | Kisspeptin-10 | 3ml Pen | 10mg
Kisspeptin-10 in bacteriostatic water, 10 mg in a preloaded 3 mL pen (3.33 mg/mL)
Kisspeptin-10, the amidated ten-residue fragment of kisspeptin (YNWNSFGLRF-NH2), activates the kisspeptin receptor that drives GnRH release. This preloaded pen carries 10 mg of kisspeptin-10 in 3 mL of bacteriostatic water, about 3.33 mg/mL, so there is no powder to make up. Research on the peptide includes receptor and reproductive physiology, but for a solution product the most relevant papers are the ones on how quickly kisspeptin-10 breaks down.
Specifications
| Property | Value |
|---|---|
| Compound | Kisspeptin-10 KP-10; human metastin 45–54 |
| CAS number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Theoretical mass | 1302.4 Da |
| Sequence / structure | H-YNWNSFGLRF-NH₂ (10 residues; C-terminal amide) |
| Contents | Kisspeptin-10: 10 mg per 3 mL pen (0.33% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-093 |
What is in the pen
Each pen holds a 3 mL glass cartridge of sterile solution. The safety data sheet lists kisspeptin-10 at 0.33% w/v, 10 mg per pen, in bacteriostatic water with 0.9% benzyl alcohol as an antimicrobial preservative. The peptide is the same H-YNWNSFGLRF-NH2 sold freeze-dried in the kisspeptin-10 5 mg vial, theoretical mass 1302.4 Da, so the pen holds about 7.7 µmol, close to 2.6 mM. The SDS does not classify the peptide. Benzyl alcohol is listed as harmful if swallowed or inhaled, a serious eye irritant and a possible skin sensitiser.
Store the pen at 2 to 8 °C in its carton, away from light, and keep it capped once opened. Do not freeze it; discard a pen whose solution has frozen, changed colour or turned cloudy. How pens and vials compare in general is covered in peptide pen vs vial.
What the research covers
Kisspeptin-10 is the smallest kisspeptin fragment that keeps activity at the kisspeptin receptor, which signals through Gq/11 and phospholipase C1. Its stability is the main question for a ready-made solution. Liu and colleagues developed an LC-MS/MS assay for kisspeptin-10 in rat plasma and, in stability studies run with it, found that the peptide decomposed with half-lives of 6.8 minutes at 4 °C, 2.9 minutes at 25 °C and 1.7 minutes at 37 °C2. The principal breakdown product was kisspeptin-10 without its N-terminal tyrosine2. The abstract does not spell out the medium for those stability runs, but the assay was built for rat plasma, and nothing in it describes sterile bacteriostatic water.
The sequence also carries two asparagines. Asparagine deamidation in peptides has been measured directly by mass spectrometry: Robinson and Robinson determined rates for 306 asparaginyl sequences in model peptides at pH 7.4 and 37 °C, and used the method to measure how protein structure affects that rate3. That work gives no figure for kisspeptin-10 itself, and no study in these references followed kisspeptin-10 in a preserved aqueous solution, so the shelf life of the pen solution is not established here. The safety data sheet’s storage conditions are the ones to keep to.
The receptor biology, the volunteer studies and the cell work are summarised in the kisspeptin-10 (kisspeptin 45-54) guide.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How does the pen differ from the kisspeptin-10 vials?
The 5 mg and 10 mg vials hold freeze-dried kisspeptin-10 kept at −20 °C until a laboratory dissolves it. The pen holds 10 mg already in 3 mL of bacteriostatic water, about 3.33 mg/mL, and is kept at 2 to 8 °C. The peptide and its sequence are the same in all three.
How long is kisspeptin-10 stable in the pen?
No study cited here has measured it in bacteriostatic water. A 2013 study found the peptide broke down within minutes under the conditions of its rat plasma assay, losing the N-terminal tyrosine first. Keep the pen at 2 to 8 °C, dark and unfrozen, as the safety data sheet requires.
What does the certificate cover for the pen?
It covers the lot of kisspeptin-10 used to fill the pen, tested in PrymaLab's own laboratory, and not the finished solution. The testing section on this page explains where certificates are published and how one can be checked by its number and key.
Is the pen for human use?
No. The kisspeptin-10 pen is a laboratory research product. It is not approved for human or veterinary use, and nothing on this page should be read as a guide to using it in people or animals.
References
- Kirby HR, Maguire JJ, Colledge WH, et al. International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function. Pharmacol Rev. 2010;62(4):565-78. DOI · PubMed
- Liu Z, Ren C, Jones W, et al. LC-MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;926:1-8. DOI · PubMed
- Robinson NE, Robinson AB. Molecular clocks. Proc Natl Acad Sci U S A. 2001;98(3):944-9. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Kisspeptin-10
Kisspeptin-10 is also stocked as KissPeptin-10 (10mg) and Kisspeptin-10 10mg Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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