Description
PrymaLab · Research use only
Tirzepatide 40mg
Tirzepatide 40 mg, about 8.31 µmol of acylated peptide as freeze-dried powder
Tirzepatide is a 39-residue peptide agonist of the GIP and GLP-1 receptors, modified with a 20-carbon fatty diacid at lysine 20 and amidated at its C-terminus. This listing is a 40 mg vial of white lyophilized powder. Its literature includes structural work on how the peptide and its lipid side chain engage the two receptors.
Specifications
| Property | Value |
|---|---|
| Compound | Tirzepatide LY3298176; GIP/GLP-1 receptor dual agonist |
| CAS number | 2023788-19-2 |
| Molecular formula | C225H348N48O68 |
| Theoretical mass | 4813.5 Da |
| Sequence / structure | H-Y-Aib-EGTFTSDYSI-Aib-LDKIAQK(2×AEEA-γGlu-C20 diacid)AFVQWLIAGGPSSGAPPPS-NH₂ (39 residues; Aib2 and Aib13; Lys20 acylated with eicosanedioic acid via γ-Glu and two AEEA spacers; C-terminal amide) |
| Label claim | 40 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-173 |
Other fills
This is the 40 mg fill. The Tirzepatide 10mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 50 mg, 60 mg, 80 mg, 100 mg.
Molar figures for a 40 mg vial
At the theoretical mass of 4813.5 Da, 40 mg is about 8.31 µmol. Reconstituted in 1 mL that gives roughly 8.3 mM, in 2 mL about 4.2 mM and in 3 mL about 2.8 mM. Each is an upper bound, since the powder also holds residual water that the certificate measures by the Karl Fischer method. Working dilutions start from these stocks.
What the research covers
Sun and colleagues used cryogenic electron microscopy and molecular dynamics simulations to explain tirzepatide’s pharmacology at both receptors1. They showed how far the fatty acid modification, acting together with the amino acid sequence, decides the way a multireceptor agonist behaves1. On the certificate that modification is the eicosanedioic acid attached through γ-Glu and two AEEA spacers. Signalling and trial findings are on the Tirzepatide 10 mg main page.
The Retatrutide vs Tirzepatide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Why quote the fill in micromoles?
Receptor and cell experiments are normally planned in molar units. Converting the label claim once, with the theoretical mass, lets a stock be made up in millimolar terms.
How can I tell the side chain is present?
Use the LC-MS identity result on the certificate. It is compared with the theoretical mass of the complete molecule, diacid and linker included, and a chain missing the side chain would read clearly lighter.
References
- Sun B, Willard FS, Feng D, et al. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022;119(13):e2116506119. DOI · PubMed
Research use only
For laboratory research use only. Tirzepatide 40mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
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