Description
PrymaLab · Research use only
Gonadorelin 10mg Nasal Spray
Native GnRH in bacteriostatic water, 10 mg in a metered spray bottle
Gonadorelin is gonadotropin-releasing hormone made by synthesis, with the same ten residues as the peptide the hypothalamus releases to drive LH and FSH secretion. This listing holds 10 mg of it already dissolved in bacteriostatic water, in a metered nasal spray bottle. Research on GnRH is mostly about its pituitary receptor and about how pulsed and continuous exposure produce very different pituitary responses; the nasal route is not covered by the papers cited here.
Specifications
| Property | Value |
|---|---|
| Compound | Gonadorelin Native gonadotropin-releasing hormone (GnRH, LHRH) |
| CAS number | 33515-09-2 |
| Molecular formula | C55H75N17O13 |
| Theoretical mass | 1182.3 Da |
| Sequence / structure | pGlu-HWSYGLRPG-NH₂ (10 residues; N-terminal pyroglutamate; C-terminal amide) |
| Contents | Gonadorelin: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-075 |
What is in the bottle
The bottle holds a sterile solution of gonadorelin in bacteriostatic water with 0.9% benzyl alcohol as a preservative: 10 mg of peptide per bottle, at no more than 0.1% w/v according to the safety data sheet. The peptide is the same native sequence sold in the vial, pGlu-HWSYGLRPG-NH2, with a theoretical mass of 1182.3 Da.
The sheet lists gonadorelin as a respiratory sensitizer (H334) and skin sensitizer (H317), harmful if inhaled (H332), a suspected reproductive toxicant (H361) and a cause of organ damage through prolonged or repeated exposure (H372), so a spray needs care in the laboratory to avoid breathing it or getting it on skin. Benzyl alcohol adds eye irritation and skin sensitization. Store the bottle upright and capped at 2 to 8 °C, away from light, and never freeze it. General guidance on peptide solutions is in peptide storage and stability.
What the research covers
GnRH acts on the type I GnRH receptor of the pituitary, which signals mainly through the G protein Gq; Millar’s review also described coupling to other G proteins and suggested that the structure of the ligand may influence which pathway the receptor uses1. What sets the hormone apart is its dependence on rhythm. In rhesus monkeys with hypothalamic lesions, Belchetz and colleagues found that continuous GnRH did not restore sustained gonadotropin secretion while intermittent GnRH did, and that moving restored animals onto continuous delivery could desensitize the response2.
None of the references cited here studied gonadorelin given through the nose, so how much of an 1182.3 Da peptide crosses the nasal lining, and in what pattern, is not established by them. The gonadorelin guide discusses a small 1977 human study of the intranasal route, and the general question of whether peptide sprays deliver anything is discussed in do peptide nasal sprays work. The full literature on the hormone, from its sequence to its diagnostic history, is in the gonadorelin guide.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same peptide as the 2 mg vial?
Yes, the same native GnRH sequence with its pyroglutamate and amide ends. The difference is form: the vial is dry powder stored frozen, while the spray is a ready-made solution in bacteriostatic water that must be kept cold and never frozen.
Has gonadorelin been studied as a nasal spray?
Not in the papers cited on this page, which cover the GnRH receptor and a primate study of pulsed delivery. The gonadorelin guide describes an older, small human study of the nasal route, but these references give no data on how much peptide crosses the nasal lining.
What does the certificate cover?
It covers the gonadorelin lot used to fill the bottle, not the finished solution. The testing section on this page explains what is reported and where a certificate can be checked by its number and key.
Is the spray for human use?
No. It is sold for laboratory research only, is not approved for human or veterinary use, and must not be used in people or animals.
References
- Millar RP, Lu ZL, Pawson AJ, et al. Gonadotropin-releasing hormone receptors. Endocr Rev. 2004;25(2):235-75. DOI · PubMed
- Belchetz PE, Plant TM, Nakai Y, et al. Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science. 1978;202(4368):631-3. DOI · PubMed
Research use only
For laboratory research use only. Gonadorelin 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Gonadorelin
Gonadorelin is also stocked as Gonadorelin 2mg. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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