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Pinealon 10mg

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Safety data sheet PL-SDS-128 GHS: not classified as hazardous · Read the SDS · PDF

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Pinealon 10 mg: the Khavinson tripeptide Glu-Asp-Arg (EDR) as freeze-dried powder in a sealed vial, the middle of three fills. Each lot is tested in PrymaLab’s own laboratory before release. Laboratory research use only.

Description

PrymaLab · Research use only

Pinealon 10mg

Pinealon (Glu-Asp-Arg) in the 10 mg middle fill, freeze-dried in a sealed vial

Pinealon, also called EDR, is the three-residue peptide Glu-Asp-Arg from the Khavinson programme, a molecule its developers linked to brain cortex extracts rather than to the pineal gland. This vial is the 10 mg fill, freeze-dried, sitting between the 5 mg and 20 mg sizes and made as its own lot. Published work on it centres on oxidative stress and gene-expression markers in cultured neurons.

Specifications

Pinealon 10mg at a glance
Property Value
Compound Pinealon (Glu-Asp-Arg (EDR))
CAS number 175175-23-2
Molecular formula C15H26N6O8
Label claim 10 mg per vial
Form Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap
Safety data sheet PL-SDS-128

Other fills

This is the 10 mg fill. The Pinealon 20mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 5 mg, 20 mg.

What the research covers

Cell work by the developers found that Pinealon held down reactive oxygen species and reduced necrotic death in cerebellar granule cells, neutrophils and PC12 cells exposed to oxidative stress1. A physics group studying its contact with DNA concluded that it can sit partly in the major groove, with magnesium ions helping it bind2. Both lines of work are laboratory studies, and the step from them to effects in animals or people has not been made in controlled trials. The full research summary is on the Pinealon 20 mg page.

The Pinealon (EDR) guide covers the literature in more depth.

How each lot is tested

Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.

Frequently asked questions

Is the 10 mg vial the same compound as the other Pinealon fills?

Yes. Every fill holds freeze-dried Glu-Asp-Arg, CAS 175175-23-2, formula C15H26N6O8, as listed on the safety data sheet. Only the amount differs, and each fill is made and tested as a separate lot.

How should a sealed 10 mg vial be stored?

Cold, dry and dark: the safety data sheet gives −20 °C for the sealed vial, with 2 to 8 °C acceptable for short periods. Let it come to room temperature before opening, so condensation does not form on the powder.

References

  1. Khavinson V, Ribakova Y, Kulebiakin K, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011;14(5):535-41. DOI · PubMed
  2. Silanteva IA, Komolkin AV, Morozova EA, et al. Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction. J Phys Chem B. 2019;123(9):1896-1902. DOI · PubMed

Research use only

For laboratory research use only. Pinealon 10mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.

Other formats of Pinealon

Pinealon is also stocked as Pinealon 10mg Nasal Spray and Pinealon 6mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.

Additional information

Weight 0.1 lbs
Dimensions N/A

Safety data sheet PL-SDS-128 · Pinealon

GHS safety data sheet for this product (lyophilized powder, vial), revision 1.0 of October 3, 2026. Read all 16 sections or download the PDF to keep with the material.

Not classified as hazardous Not classified under OSHA HCS 2012 / GHS. No pictogram, signal word or hazard statement is required; handle as a pharmacologically active laboratory chemical.
CompositionPinealon (CAS 175175-23-2) · ≥ 95% (dry basis, as supplied), 5 mg, 10 mg, 20 mg per vial
ClassificationNot classified as hazardous under OSHA HCS 2012 (29 CFR 1910.1200) or UN GHS, on the basis of the supplier safety data sheets consulted.
Physical stateSolid. White to off-white lyophilized powder.
Storage−20 °C (sealed vial), desiccated and protected from light; 2–8 °C acceptable for short periods
HandlingOpen vials only in a clean area. Avoid generating or inhaling dust; weigh or reconstitute inside a ventilated enclosure when the full contents are handled as a dry powder. Reconstitute by adding diluent slowly to the vial wall; do not shake. Wash hands after handling.
First aidEyes: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do; continue rinsing. If eye irritation persists, get medical advice. Skin: Take off contaminated clothing. Wash the skin with plenty of soap and water. If irritation or a rash develops, get medical advice. Ingestion: Rinse mouth. Do not induce vomiting. Call a POISON CENTER or doctor if you feel unwell.
DisposalChemical waste through a licensed contractor; do not pour down the drain.
TransportNot regulated as a dangerous good (DOT / IATA / IMDG).

For laboratory research use only. Not for human or veterinary use.

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Peptide Research Articles

Pinealon research library featured image: the Khavinson tripeptide Glu-Asp-Arg was synthesized from a cortex extract, named after the pineal gland it was never shown to act on, and has cell and rodent data from one institute and no controlled human trial

Pinealon (EDR): The Brain Tripeptide Named After the Pineal Gland, the Inverted-U Response Curve, and the 72-Patient Trial Nobody Can Find

Every page calls Pinealon a pineal peptide. Its developers do not: the 2011 paper that characterised Glu-Asp-Arg says it was synthesized from the amino-acid composition of a cortex extract, and in pineal culture it did nothing. What remains is a real set of cell and rodent results from one institute, a dose curve that bends over above 20 ng/mL, and no controlled human trial.

Peptide bioregulators by organ system, infographic

Peptide Bioregulators by Organ System: A Research Overview

Peptide bioregulators are a family of very short synthetic peptides, most of them two to four amino acids, each tied to a specific organ. They came out of one Soviet-era research program and they remain an odd corner of peptide science: a large catalog, a bold mechanistic claim, and a thin independent evidence base. This research-use-only overview maps which compound goes with which tissue and says plainly what the research does and does not support.

List of peptides studied for brain function and cognition.

Peptides Studied for Brain and Cognition: A Research Overview

Several research peptides are studied for how they affect the brain’s plasticity machinery in animal and cell models. This research-use-only overview compares four of the most-studied (Semax, Dihexa, PE-22-28, and P21), explains their different mechanisms, links to each full reference, and states what the models do and do not prove.

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