Description
PrymaLab · Research use only
Ipamorelin 10mg Nasal Spray
Ipamorelin in bacteriostatic water, 10 mg per bottle, in a metered nasal spray
Ipamorelin is a synthetic five-residue growth hormone secretagogue that acts on the ghrelin receptor. This listing is a nasal spray bottle holding 10 mg of the peptide as a sterile solution in bacteriostatic water, ready to use without reconstitution. Research on ipamorelin itself comes from cell, rat and pig studies of growth hormone release and selectivity, while the case for the nasal route rests on a separate literature about peptides in general.
Specifications
| Property | Value |
|---|---|
| Compound | Ipamorelin NNC 26-0161; selective growth hormone secretagogue pentapeptide |
| CAS number | 170851-70-4 |
| Molecular formula | C38H49N9O5 |
| Theoretical mass | 711.9 Da |
| Sequence / structure | H-Aib-H-[D-2-Nal]-[D-Phe]-K-NH₂ (5 residues; C-terminal amide) |
| Contents | Ipamorelin: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-091 |
What is in the bottle
Each bottle holds 10 mg of ipamorelin, the same Aib-His-D-2-Nal-D-Phe-Lys-NH₂ sold in the vials, at no more than 0.1% w/v (1 mg/mL). It is dissolved in bacteriostatic water, which contains 0.9% benzyl alcohol as an antimicrobial preservative, with water for injection making up the balance. The safety data sheet lists ipamorelin as a skin and eye irritant that may cause respiratory irritation (H315, H319, H335), and benzyl alcohol as harmful if swallowed or inhaled, an eye irritant and a possible skin sensitiser.
Store the bottle upright and capped at 2 to 8 °C, away from light, and never freeze it. For a concentration you set yourself, the Ipamorelin 10 mg vial holds dry peptide that can be dissolved in any volume. General guidance on peptide solutions is in peptide storage and stability.
What the research covers
Ipamorelin came out of a chemistry programme on analogues of growth hormone-releasing peptide-1 that lack its central Ala-Trp pair1. In rat pituitary cells it released growth hormone almost as effectively as GHRP-6, and antagonist experiments placed its action at the GHRP receptor rather than the GHRH receptor1. In swine, GHRP-6 and GHRP-2 raised ACTH and cortisol while ipamorelin did not go beyond the levels seen after GHRH, which is why the authors called it the first selective growth hormone secretagogue1. Its receptor had been cloned two years earlier from pig and human pituitary and hypothalamus as the target of the synthetic secretagogues, at a time when its natural ligand was still unknown2.
The nasal route raises separate questions. Illum’s 2002 review described rising pharmaceutical interest in nasal delivery for peptides and other hard-to-deliver drugs, and discussed evidence that some drugs pass directly from the nose to the brain along the olfactory pathway, with proof-of-concept examples in people3. None of the papers cited here studied ipamorelin given by the nasal route, so how much of a 711.9 Da peptide crosses the nasal lining, and where it goes, is not established. The full literature on the peptide is in sermorelin vs ipamorelin vs tesamorelin.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same peptide as the ipamorelin vials?
Yes, the same five-residue sequence with a C-terminal amide and a theoretical mass of 711.9 Da. The vials are dry powder kept at −20 °C; the spray is a ready-made solution in bacteriostatic water that is kept cold but never frozen.
How much ipamorelin is in one bottle?
10 mg, at no more than 0.1% w/v according to the safety data sheet. The amount and concentration are also on the bottle label. Where a study needs a different concentration, the 5 mg and 10 mg vials can be dissolved in whatever volume the work calls for.
Has ipamorelin been studied as a nasal spray?
Not in any paper cited on this page. The nasal delivery review covers peptides and other drugs in general, and the ipamorelin papers used other routes, so there are no published findings specific to this format to point to.
Is the spray for human use?
No. It is sold for laboratory research only and is not approved for human or veterinary use by the FDA or any other authority. It must not be given to people or animals.
References
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61. DOI · PubMed
- Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-7. DOI · PubMed
- Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today. 2002;7(23):1184-9. DOI · PubMed
Research use only
For laboratory research use only. Ipamorelin 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Ipamorelin
Ipamorelin is also stocked as Ipamorelin 5mg, CJC-1295 (no DAC), Ipamorelin 10mg (Blend), CJC-1295 (NO DAC) 5MG, CJC-1295 (NO DAC) 10MG and CJC-1295 (No DAC) + Ipamorelin 15mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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