Description
PrymaLab · Research use only
Preloaded Autoinjector | Epithalon | 3ml Pen | 15mg
Epitalon in solution at 5 mg/mL, 15 mg in a preloaded 3 mL pen
Epitalon (Epithalon) is the synthetic tetrapeptide Ala-Glu-Asp-Gly from Vladimir Khavinson’s bioregulator programme, modelled on a bovine pineal extract. This listing is a preloaded pen holding 3 mL of ready-made solution at 5 mg/mL, 15 mg of peptide in all, so there is no powder to dissolve. Published work on the peptide concerns telomerase in cultured cells and ageing and tumour markers in rodents, nearly all of it from the developers’ own laboratories.
Specifications
| Property | Value |
|---|---|
| Compound | Epitalon Epithalon; Ala-Glu-Asp-Gly (AEDG); Khavinson pineal peptide bioregulator |
| CAS number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Theoretical mass | 390.4 Da |
| Sequence / structure | H-AEDG-OH (4 residues; free N- and C-termini) |
| Contents | Epitalon: 15 mg per 3 mL pen (0.5% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-050 |
What is in the pen
Each pen holds a 3 mL glass cartridge of sterile aqueous solution. The safety data sheet lists Epitalon at 0.5% w/v, which is 5 mg/mL and 15 mg per pen, dissolved in bacteriostatic water with 0.9% benzyl alcohol as an antimicrobial preservative. From the certificate mass of 390.4 Da, 5 mg/mL is about 12.8 mM. The peptide is not classified as hazardous; benzyl alcohol is listed as harmful if swallowed or inhaled, a serious eye irritant and a possible cause of allergic skin reactions.
Keep the pen at 2 to 8 °C in its carton, away from light, and capped once in use. It must not be frozen, and a pen whose solution has frozen, changed colour or turned cloudy should be discarded. The same peptide is sold dry in Epitalon 50 mg vials, and peptide pen vs vial sets out the general trade-offs between the two formats.
Why time in solution matters for AEDG
Epitalon ends in aspartate followed by glycine. Aspartyl residues in peptides can close into a succinimide ring that reopens as isomerised or racemised forms, a route Clarke’s group described in the late 1980s as a source of protein degradation1,2. Oliyai and Borchardt followed the same Asp-Gly pairing in a model hexapeptide in water: at strongly acidic pH the Asp-Gly bond was mainly cleaved, and at pH 4 and 5 the peptide also isomerised through a cyclic imide to an iso-Asp form3. An isomer has exactly the parent’s mass, so an LC-MS identity check cannot separate the two. No study has measured how fast this happens to Epitalon in the pen’s solution, which is why the cold storage limits on the safety data sheet are the ones to follow.
What the research covers
Epitalon’s sequence was built to mirror the amino-acid make-up of epithalamin, a polypeptide extract of bovine pineal glands4. A 2025 review collected reports that it acts on melatonin synthesis, interleukin-2 mRNA and the activity of enzymes including telomerase, and judged its mechanism still uncertain4. The same review pointed out how few physical, chemical and structural studies of the peptide exist4, which leaves little published on how AEDG behaves once dissolved.
In rodent studies from the developers’ collaboration, animals were followed for life. Female SHR mice showed no change in mean lifespan, food intake or body weight, a 12.3% longer maximum lifespan, fewer chromosome aberrations in bone marrow and far less leukaemia than controls5. Male rats housed under different lighting regimes again showed almost no change in mean lifespan, a normalised population ageing rate under constant and natural light, and fewer spontaneous tumours in every group6.
These studies prepared the peptide in the laboratory or added it to culture medium. None involved a ready-made solution or a pen, and none reports how long AEDG keeps in water. The Epitalon guide sets out the full record, including the 2003 telomerase report, the monkey melatonin studies and the human reports on the pineal extract.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How does the pen differ from the Epitalon vials?
The vials hold freeze-dried peptide that is stored at −20 °C and dissolved in the laboratory when needed. The pen holds the same AEDG already dissolved at 5 mg/mL and is kept at 2 to 8 °C. Dry powder is chemically quiet; a solution starts the aspartate chemistry described above from the day it is filled.
What does the certificate cover for the pen?
It covers the lot of peptide used to fill the pen, not the finished solution in the cartridge. The testing section on this page explains what each certificate reports and how to check one by its number and key.
Do the published studies apply to the pen?
Only as background on the compound. The papers describe Epitalon itself in cells, mice and rats. None used a preloaded solution, and none measured the stability of AEDG in water, so the storage limits on the safety data sheet are the guide for the pen.
Is the pen intended for human use?
No. Like every PrymaLab product it is sold only for laboratory research. It is not approved for human or veterinary use, and nothing on this page should be read as a guide to using it in people or animals.
References
- Geiger T, Clarke S. Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation. Journal of Biological Chemistry. 1987;262(2):785-794. DOI
- Stephenson RC, Clarke S. Succinimide Formation from Aspartyl and Asparaginyl Peptides as a Model for the Spontaneous Degradation of Proteins. Journal of Biological Chemistry. 1989;264(11):6164-6170. DOI
- Oliyai C, Borchardt RT. Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide. Pharm Res. 1993;10(1):95-102. DOI · PubMed
- Araj SK, Brzezik J, Mądra-Gackowska K, et al. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6). DOI · PubMed
- Anisimov VN, Khavinson VKh, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. DOI · PubMed
- Vinogradova IA, Bukalev AV, Zabezhinski MA, et al. Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens. Bull Exp Biol Med. 2008;145(4):472-7. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Epithalon
Epithalon is also stocked as Epitalon 10mg and Epitalon 10mg Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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