Description
PrymaLab · Research use only
Vilon 10mg Nasal Spray
Vilon (Lys-Glu) in bacteriostatic water, 10 mg per metered spray bottle
This is Vilon, the Khavinson dipeptide Lys-Glu (KE), supplied as a sterile solution in a metered nasal spray bottle that holds 10 mg of peptide. At 275.3 Da it is the smallest molecule in the bioregulator series, which its developers associated with the thymus and immune function. The research behind it is mainly Russian cell and rat work from one group, none of it by the nasal route; a separate review literature covers nasal delivery of peptides in general.
Specifications
| Property | Value |
|---|---|
| Compound | Vilon Lys-Glu (KE); Khavinson thymic peptide bioregulator |
| CAS number | 45234-02-4 |
| Molecular formula | C11H21N3O5 |
| Theoretical mass | 275.3 Da |
| Sequence / structure | H-KE-OH (2 residues; free N- and C-termini) |
| Contents | Vilon: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-183 |
What is in the bottle
Each bottle contains 10 mg of Vilon dissolved in bacteriostatic water with 0.9% benzyl alcohol as a preservative, at no more than 0.1% w/v. In molar terms, 10 mg of a 275.3 Da peptide is about 36 µmol. The safety data sheet does not classify the peptide. Benzyl alcohol carries hazard statements for harm if swallowed or inhaled, serious eye irritation and allergic skin reactions.
Keep the bottle upright and capped at 2 to 8 °C, away from light, and do not freeze it. The same peptide is sold dry in the Vilon 20 mg vial, and the peptide storage and stability article covers general handling of peptide solutions.
What the research covers
Vilon research comes almost entirely from Vladimir Khavinson’s group in St Petersburg and its collaborators. In rats aged 3 and 11 months, Vilon given by mouth changed the activity of several digestive enzymes, among them maltase, invertase and alkaline phosphatase, and the change was greatest in the older animals1. That paper, like most of the Vilon work, was published in Russian and is read in English translation. In leukocytes from people aged 75 to 88 it was one of five short peptides that loosened condensed chromatin and activated ribosomal genes2. The group reads results like these as evidence that short peptides regulate genes, a model that has not been tested outside its own circle in the papers cited here.
Nasal delivery is a separate subject. Illum’s 2002 review described rising pharmaceutical interest in the nasal route for peptides and other difficult drugs, and discussed evidence that some drugs travel from the nose directly to the brain along the olfactory pathway, with proof-of-concept examples in humans3. That review did not study Vilon, and no Vilon paper cited here used the nose. Whether the dipeptide crosses the nasal lining, and where it goes if it does, is not known from these sources. The Vilon guide covers the full literature on the compound.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same Vilon as the vial?
Yes. The bottle holds the same Lys-Glu dipeptide described in the specifications, already dissolved in bacteriostatic water. The vial holds 20 mg of dry powder stored at −20 °C; the spray holds 10 mg in solution, stored at 2 to 8 °C and never frozen.
Has Vilon been studied as a nasal spray?
No paper cited on this page did so. The Vilon studies used human leukocytes and rats, and the nasal delivery review discusses peptides in general. There are no published findings specific to this format to point to.
Which lot does the certificate describe?
The certificate covers the Vilon peptide lot used to make the solution, not the filled bottle. Published certificates are listed on the testing results page and can be checked by number and key on the verify page.
Is Vilon nasal spray for human use?
No. It is a laboratory research product, not approved by the FDA or any other authority for human or veterinary use, and it must not be given to people or animals.
References
- Khavinson VK, Timofeeva NM, Malinin VV, et al. Effect of the dipeptide vilon on activity of digestive enzyme in rats of various ages. Bull Exp Biol Med. 2001;131(6):583-5. DOI · PubMed
- Khavinson VKh, Lezhava TA, Malinin VV. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull Exp Biol Med. 2004;137(1):78-81. DOI · PubMed
- Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today. 2002;7(23):1184-9. DOI · PubMed
Research use only
For laboratory research use only. Vilon 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Vilon
Vilon is also stocked as Vilon 6mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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