Description
PrymaLab · Research use only
KPV 10mg Nasal Spray
KPV, the Lys-Pro-Val tripeptide, 10 mg in solution in a metered spray bottle
KPV is a tripeptide, Lys-Pro-Val, identical to residues 11 to 13 of alpha-MSH and investigated mainly for anti-inflammatory activity. In this listing it is dissolved in bacteriostatic water, 10 mg per bottle, in a nasal spray bottle. Research on KPV itself has been done in intestinal and immune cell lines and in mouse colitis models, and no cited study used a nasal spray.
Specifications
| Property | Value |
|---|---|
| Compound | KPV Lys-Pro-Val; α-MSH(11–13) |
| CAS number | 67727-97-3 |
| Molecular formula | C16H30N4O4 |
| Theoretical mass | 342.4 Da |
| Sequence / structure | H-KPV-OH (3 residues; free N- and C-termini) |
| Contents | KPV: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-099 |
What is in the bottle
According to the safety data sheet, each bottle holds 10 mg of KPV as a sterile solution in bacteriostatic water, with the peptide at no more than 0.1% w/v and 0.9% benzyl alcohol as the preservative. At the certificate’s theoretical mass of 342.4 Da, 10 mg is about 29.2 µmol. The peptide is not classified as hazardous. Benzyl alcohol carries hazard statements for harm if swallowed or inhaled, serious eye irritation and possible allergic skin reactions.
Keep the bottle at 2 to 8 °C, upright, capped and out of the light, and do not freeze it. Background on keeping peptide solutions is in peptide storage and stability.
What the research covers
KPV sits at the C-terminus of alpha-MSH, a 13-residue hormone whose anti-inflammatory effects were shown in animal models of skin, joint, eye, brain, airway and gut inflammation. Brzoska and colleagues described KPV as retaining that activity while lacking the hormone’s effect on pigmentation1. Its best-characterised way into cells is PepT1, a membrane transporter that accepts di- and tripeptides but not free amino acids or longer chains2. Dalmasso’s group found that KPV crossed into intestinal epithelial cells and T cells by this route, where it lowered NF-kB activation, and that it reduced pro-inflammatory cytokine expression in two mouse colitis models3.
None of this concerns the nose. The references on this page contain no study of KPV applied to the nasal lining, so how much of it crosses nasal tissue, and whether PepT1 plays any part there, is unknown. Daniel’s review describes PepT1 as an intestinal transporter whose expression shifts with nutritional status and disease2; it says nothing about nasal epithelium. For this format the papers describe the molecule, not the spray. The KPV peptide guide covers the full set of studies, including those outside the gut.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the spray the same KPV as the vials?
Yes, the same H-KPV-OH tripeptide with a theoretical mass of 342.4 Da. The vials hold it as dry powder kept at −20 °C, while the spray holds 10 mg already dissolved in bacteriostatic water, kept cold but never frozen.
Has KPV been studied as a nasal spray?
Not in any of the papers cited here. The published KPV work used intestinal and immune cell lines and mouse colitis models, so there are no findings specific to nasal delivery to report.
What does the certificate cover?
It covers the KPV lot used to make the solution, not the finished bottle. Certificates are listed on the testing results page and can be confirmed by number and key on the verify page.
Is the spray for human use?
No. It is sold for laboratory research only and is not approved by the FDA or any other authority for use in people or animals.
References
- Brzoska T, Luger TA, Maaser C, et al. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. 2008;29(5):581-602. DOI · PubMed
- Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol. 2004;66:361-84. DOI · PubMed
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-78. DOI · PubMed
Research use only
For laboratory research use only. KPV 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of KPV
KPV is also stocked as KPV (5mg), KPV (10mg) and KPV 5mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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