Description
PrymaLab · Research use only
GHRP-6 10mg Nasal Spray
GHRP-6, 10 mg in bacteriostatic water, in a nasal spray bottle
GHRP-6 is a synthetic six-residue peptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, that releases growth hormone by acting at the growth hormone secretagogue receptor. This listing is 10 mg of GHRP-6 dissolved in bacteriostatic water and supplied in a nasal spray bottle. Research on the peptide concerns growth hormone release in animals and people and the receptor and natural ligand it led researchers to; nasal delivery of GHRP-6 is not covered by the papers cited here.
Specifications
| Property | Value |
|---|---|
| Compound | GHRP-6 Growth hormone-releasing peptide-6 |
| CAS number | 87616-84-0 |
| Molecular formula | C46H56N12O6 |
| Theoretical mass | 873.0 Da |
| Sequence / structure | H-H-[D-Trp]-A-W-[D-Phe]-K-NH₂ (6 residues; C-terminal amide) |
| Contents | GHRP-6: 10 mg per bottle (≤ 0.1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a metered nasal spray bottle |
| Storage, sealed | Store at 2–8 °C, protected from light; do not freeze |
| Safety data sheet | PL-SDS-066 |
What is in the bottle
The safety data sheet gives the contents as 10 mg of GHRP-6 per bottle at no more than 0.1% w/v, in bacteriostatic water: sterile water with 0.9% w/v benzyl alcohol as an antimicrobial preservative. GHRP-6 itself is not classified as hazardous. Benzyl alcohol is classified as harmful if swallowed or inhaled, a serious eye irritant and a skin sensitiser. Keep the bottle upright and capped at 2 to 8 °C, protected from light, and never freeze it. The same peptide is available as dry powder in the GHRP-6 5 mg vial.
What the research covers
GHRP-6 predates the receptor it acts on. When Howard and colleagues cloned the growth hormone secretagogue receptor in 1996, from pig and human pituitary and hypothalamus, they concluded that the synthetic secretagogues were standing in for a hormone nobody had yet found1. Kojima’s group isolated that hormone, ghrelin, from rat stomach three years later; its activity depends on an octanoyl group attached to serine 32. Ghrelin given to rats increased food intake as well as growth hormone3, and that result is the main basis for describing GHRP-6 as an appetite-stimulating peptide, although none of the abstracts here measured feeding after GHRP-6 itself.
Nasal delivery is a separate question with no data on this page. None of the cited papers gave GHRP-6 through the nose, so how much of an 873 Da hexapeptide crosses the nasal lining, and how quickly, is not established here. The discovery work, the early human studies and the pharmacokinetics measured in healthy men are summarised on the GHRP-6 10 mg vial page, and the GHRP-2 vs GHRP-6 guide compares it with GHRP-2.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the bottle, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How much GHRP-6 does the bottle contain?
10 mg, according to the safety data sheet, at a concentration of no more than 0.1% w/v. For work that needs a different concentration, the 5 mg and 10 mg vials supply dry GHRP-6 that can be dissolved in whatever volume the experiment requires.
How is the spray different from the vials?
Same peptide, different state. The vials hold freeze-dried GHRP-6 that is stored at −20 °C. The spray holds it already dissolved in bacteriostatic water with benzyl alcohol as preservative, and it is kept at 2 to 8 °C and never frozen.
Has GHRP-6 been studied as a nasal spray?
Not in the papers cited on this page. The human data here come from studies that measured growth hormone or plasma levels after other routes, so no published finding specific to nasal delivery of GHRP-6 is available to report.
Can the spray be used in people?
No. It is sold only for laboratory research, has no FDA or other regulatory approval for human or veterinary use, and must not be given to people or animals.
References
- Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-7. DOI · PubMed
- Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-60. DOI · PubMed
- Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000;141(11):4325-8. DOI · PubMed
Research use only
For laboratory research use only. GHRP-6 10mg Nasal Spray is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of GHRP-6
GHRP-6 is also stocked as GHRP-6 10mg preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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