Description
PrymaLab · Research use only
Preloaded Autoinjector | GHRP-6 | 3ml Pen | 10mg
10 mg of GHRP-6 already dissolved, in a preloaded 3 mL autoinjector pen
GHRP-6 is the hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, a synthetic growth hormone secretagogue that acts at the ghrelin receptor. This listing is a preloaded autoinjector pen containing 10 mg of GHRP-6 in solution in a 3 mL cartridge, ready made rather than freeze-dried. Studies of GHRP-6 cover its pituitary action in animals and people, its pharmacokinetics in healthy men and, through the closely related hexarelin, a second binding protein in the heart.
Specifications
| Property | Value |
|---|---|
| Compound | GHRP-6 Growth hormone-releasing peptide-6 |
| CAS number | 87616-84-0 |
| Molecular formula | C46H56N12O6 |
| Theoretical mass | 873.0 Da |
| Sequence / structure | H-H-[D-Trp]-A-W-[D-Phe]-K-NH₂ (6 residues; C-terminal amide) |
| Contents | GHRP-6: 10 mg per 3 mL pen (0.33% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-065 |
What is in the pen
Per the listing, each pen holds 10 mg of GHRP-6 in a 3 mL cartridge. The peptide is the one sold freeze-dried in the GHRP-6 10 mg vial: six residues, a C-terminal amide and a theoretical mass of 873.0 Da, so 10 mg is about 11.5 µmol.
PrymaLab has not yet published a safety data sheet for the pen, and the diluent is not stated on this page. The sheet for GHRP-6 in solution, written for the nasal spray, gives storage at 2 to 8 °C, protected from light and not frozen. With two tryptophans in the sequence, keeping a cartridge of solution out of the light is part of keeping it intact. Peptide pen vs vial sets out the general differences between the two formats.
What the research covers
GHRP-6 belongs to a class that Bowers, reviewing it in 1998, described as releasing growth hormone through a dual, complementary action on the hypothalamus and the pituitary1. In the one detailed pharmacokinetic study cited here, covering nine healthy men, plasma GHRP-6 fell in two phases, with a distribution half-life of 7.6 minutes and an elimination half-life of 2.5 hours2.
The class also has a binding partner outside the pituitary. Bodart and colleagues labelled rat heart membranes with a photoactivatable form of hexarelin, a GHRP-6 analogue carrying one extra methyl group, and identified the 84 kDa binding protein as CD36, a glycoprotein on heart muscle cells and microvascular endothelial cells3. In perfused hearts hexarelin raised coronary perfusion pressure, and the effect was missing in hearts lacking CD363. The abstract does not show whether GHRP-6 binds CD36 to the same extent.
None of this work used a ready-made solution or addressed how long GHRP-6 stays intact in water. The GHRP-6 10 mg vial page has the full summary of the discovery and the human studies.
The GHRP-2 vs GHRP-6 guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
What is the difference between the pen and the GHRP-6 vials?
The vials contain dry GHRP-6, stored frozen and dissolved when needed at a concentration you choose. The pen contains 10 mg already dissolved in a 3 mL cartridge, so the concentration is set and the peptide is stored as a solution, cold but never frozen.
How should the pen be stored?
At 2 to 8 °C, out of the light and never frozen, as PrymaLab's safety data sheet for GHRP-6 in solution specifies. Keep it in its packaging away from light, since the two tryptophan residues in GHRP-6 are sensitive to it.
Is there a certificate for the pen?
Yes, for the GHRP-6 peptide lot used to fill it. That certificate does not test the solution in the finished cartridge. The testing section on this page explains how certificates are listed and how to verify one by number and key.
Is the pen meant for human use?
No. It is a laboratory research product, not approved by the FDA or any other authority for use in people or animals, and the autoinjector format does not change that. It must not be given to people or animals.
References
- Bowers CY. Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54(12):1316-29. DOI · PubMed
- Cabrales A, Gil J, Fernández E, et al. Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers. Eur J Pharm Sci. 2013;48(1-2):40-6. DOI · PubMed
- Bodart V, Febbraio M, Demers A, et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res. 2002;90(8):844-9. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of GHRP-6
GHRP-6 is also stocked as GHRP-6 5mg and GHRP-6 10mg Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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