Description
PrymaLab · Research use only
Preloaded Autoinjector | GHRP-2 | 3ml Pen | 10mg
GHRP-2 already in solution, 10 mg in a preloaded 3 mL autoinjector pen
GHRP-2 (pralmorelin) is a synthetic hexapeptide that acts at the growth hormone secretagogue receptor, the receptor whose natural ligand is ghrelin. This listing is a preloaded autoinjector pen holding 10 mg of GHRP-2 already in solution in a 3 mL cartridge, so there is no powder to dissolve. Research on GHRP-2 covers growth hormone release, its use in testing pituitary reserve and its effects on appetite, most of it from small human studies.
Specifications
| Property | Value |
|---|---|
| Compound | GHRP-2 Pralmorelin; KP-102; growth hormone-releasing hexapeptide |
| CAS number | 158861-67-7 |
| Molecular formula | C45H55N9O6 |
| Theoretical mass | 818.0 Da |
| Sequence / structure | H-[D-Ala]-[D-2-Nal]-A-W-[D-Phe]-K-NH₂ (6 residues; C-terminal amide) |
| Contents | GHRP-2: 10 mg per 3 mL pen (0.33% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-062 |
What is in the pen
The listing gives the contents as 10 mg of GHRP-2 in a 3 mL cartridge. The peptide is the same six-residue sequence sold freeze-dried in the GHRP-2 10 mg vial, H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 with a C-terminal amide and a theoretical mass of 818.0 Da, which puts the pen’s 10 mg at about 12.2 µmol.
PrymaLab has not yet published a safety data sheet for the pen, so the diluent and any preservative are not stated on this page. The safety data sheet for GHRP-2 in solution, written for the nasal spray, gives storage at 2 to 8 °C, protected from light and never frozen. For the general differences between a ready-made solution and dry powder, see peptide pen vs vial.
What the research covers
GHRP-2 descends from an earlier hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (now called GHRP-6), which Bowers and colleagues described in 19841. That peptide released growth hormone from pituitary tissue in vitro and in rats, monkeys, lambs and calves without releasing LH, FSH, TSH or prolactin, and somatostatin blocked its effect1. GHRP-2 shares its last four residues. The receptor the class acts on was cloned twelve years later from pig and human pituitary and hypothalamus, a G protein-coupled receptor the authors tied to the pulsatile release of growth hormone2.
Effects beyond growth hormone have been recorded in people. In a 12-month study of ten prepubertal children with growth hormone deficiency, seven reported an increase in appetite during the first six months; body mass index tended upward, but the change was not statistically significant, and the authors described the appetite effect as transient3.
None of the cited work used a ready-made solution, and none of the abstracts reports how long GHRP-2 stays intact in water. The diagnostic, pharmacokinetic and food intake studies are summarised on the GHRP-2 10 mg vial page, and the GHRP-2 vs GHRP-6 guide compares the two related peptides.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How does the pen differ from the GHRP-2 vials?
The vials hold freeze-dried GHRP-2 that is kept at −20 °C and dissolved in the lab when needed, at whatever concentration the work calls for. The pen holds 10 mg already in solution in a 3 mL cartridge, so the concentration is fixed and the peptide spends its whole shelf life in liquid.
How should the pen be stored?
Cold and dark: 2 to 8 °C, away from light, and never frozen. Those are the conditions on PrymaLab's safety data sheet for GHRP-2 in solution, since the pen does not yet have a sheet of its own.
What does the certificate cover for the pen?
It covers the lot of GHRP-2 peptide used to fill the pen, not the finished solution in the cartridge. The testing section on this page explains what each certificate reports and how to look one up by number and key.
Is the pen intended for human use?
No. It is sold for laboratory research only, is not approved by the FDA or any other authority for human or veterinary use, and must not be given to people or animals. The autoinjector format does not change that.
References
- Bowers CY, Momany FA, Reynolds GA, et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 1984;114(5):1537-45. DOI · PubMed
- Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-7. DOI · PubMed
- Mericq V, Cassorla F, Bowers CY, et al. Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children. J Pediatr Endocrinol Metab. 2003;16(7):981-5. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of GHRP-2
GHRP-2 is also stocked as GHRP-2 5mg and GHRP-2 Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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