Description
PrymaLab · Research use only
Preloaded Autoinjector | Cortagen | 3ml Pen | 20mg
Cortagen (AEDP) in solution, 20 mg in a preloaded 3 mL pen
Cortagen, the tetrapeptide Ala-Glu-Asp-Pro, is a synthetic cerebral-cortex bioregulator from the Khavinson programme in St Petersburg. This listing is a preloaded pen holding 20 mg of it dissolved in 3 mL of solution, about 6.7 mg/mL, so there is no powder to dissolve. Published work on cortagen is thin: short Russian reports on nerve regeneration and on oxidative stress markers in rats.
Specifications
| Property | Value |
|---|---|
| Compound | Cortagen Ala-Glu-Asp-Pro (AEDP); Khavinson cerebral-cortex peptide bioregulator |
| CAS number | Not assigned |
| Molecular formula | C17H26N4O9 |
| Theoretical mass | 430.4 Da |
| Sequence / structure | H-AEDP-OH (4 residues; free N- and C-termini) |
| Contents | Cortagen: 20 mg per 3 mL pen (0.67% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-044 |
What is in the pen
Each pen contains a 3 mL glass cartridge of sterile aqueous solution. The safety data sheet lists cortagen at 0.67% w/v, 20 mg per pen, in bacteriostatic water with 0.9% benzyl alcohol as an antimicrobial preservative. At the certificate mass of 430.4 Da, that is roughly 15.5 mM. The peptide is not classified as hazardous; benzyl alcohol is listed as harmful if swallowed or inhaled, a serious eye irritant and a possible skin sensitiser.
Keep the pen at 2 to 8 °C in its carton, away from light, and capped once in use. Do not freeze it, and discard it if the solution has frozen, changed colour or turned cloudy. In water the Asp-Pro bond is the part of the molecule most open to cleavage, which in hot dilute acid ran 8 to 20 times faster than at other aspartyl bonds1; its rate in the pen’s solution has not been measured. The freeze-dried Cortagen 20 mg vial holds the same peptide, and peptide pen vs vial covers the general trade-offs.
What the research covers
Cortagen is one of the short synthetic peptides of the Khavinson programme, and its literature is brief. Two short reports from 2000 and 2002 looked at peripheral nerve, one at regeneration of the sciatic nerve and one at a delayed effect on the recovery of injured nerve function2,3. Their abstracts are not available here, so the animal models and the size of any effect cannot be given. The 2002 report appeared in Doklady Biological Sciences, the English edition of a Russian academy journal3.
The one abstract on cortagen’s biology comes from a rat study by Kozina. Epithalon and cortagen lowered lipid peroxidation products and reduced oxidative modification of proteins, while antioxidant activity in serum and cerebral cortex fell at the same time4. The abstract is a single sentence and gives no group sizes or effect sizes.
Most of the primary record on cortagen looks like this: short reports in Russian journals or their English translations, largely from the developers’ circle. No study used a ready-made solution, and none measured the stability of AEDP in water. The Cortagen 20 mg vial page has the full research summary, including the chromatin paper and what is borrowed from sibling peptides.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How does the pen differ from the Cortagen vial?
Both hold 20 mg of the same tetrapeptide. In the vial it is freeze-dried powder stored at −20 °C; in the pen it is already dissolved in 3 mL of bacteriostatic water and stored at 2 to 8 °C. The vial keeps the Asp-Pro bond dry until it is needed; the pen gives a fixed, ready concentration.
What does the certificate cover for the pen?
The lot of peptide used to fill the pen, not the finished solution in the cartridge. The testing section on this page describes what each certificate reports and how to check one by its number and key.
Do the published cortagen studies apply to the pen?
Only as background on the peptide. The papers describe nerve and oxidative stress work in animals, and none used a preloaded solution or measured how long the peptide stays intact in water. For the pen, the storage limits on the safety data sheet are the ones to follow.
Is the pen for human use?
No. Like every PrymaLab product it is sold only for laboratory research, has no approval for human or veterinary use, and must not be used in people or animals.
References
- Marcus F. Preferential cleavage at aspartyl-prolyl peptide bonds in dilute acid. Int J Pept Protein Res. 1985;25(5):542-6. DOI · PubMed
- Turchaninova LN, Kolosova LI, Malinin VV, et al. Effect of tetrapeptide cortagen on regeneration of sciatic nerve. Bulletin of Experimental Biology and Medicine. 2000;130(6):1172-1174. DOI
- Kolosova LI, Moiseeva AB, Turchaninova LN, et al. The delayed effect of cortagen on the restoration of injured nerve function. Dokl Biol Sci. 2002;384:183-4. DOI · PubMed
- Kozina LS. Effects of bioactive tetrapeptides on free-radical processes. Bull Exp Biol Med. 2007;143(6):744-6. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of Cortagen
Cortagen is also stocked as Cortagen 20mg Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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