Description
PrymaLab · Research use only
Preloaded Autoinjector | NAD+ (injectable) | 3ml Pen | 500mg/ml
NAD+ at 500 mg/mL in bacteriostatic water, 1,500 mg in a 3 mL preloaded pen
NAD+, the oxidized form of nicotinamide adenine dinucleotide, is a coenzyme that every living cell uses, and it is not a peptide. This listing is the stronger of two NAD+ pens: a 3 mL glass cartridge of NAD+ dissolved in bacteriostatic water at 500 mg/mL, 1,500 mg in total, inside a preloaded autoinjector pen. Research on NAD+ is about electron transfer, the enzymes that use it up, and the age-related decline reported in animals.
Specifications
| Property | Value |
|---|---|
| Compound | NAD+ β-Nicotinamide adenine dinucleotide, oxidized (free acid); coenzyme, not a peptide |
| CAS number | 53-84-9 |
| Molecular formula | C21H27N7O14P2 |
| Theoretical mass | 663.4 Da |
| Sequence / structure | Dinucleotide: adenosine 5′-monophosphate joined through a pyrophosphate bridge to nicotinamide 5′-mononucleotide; oxidized form. |
| Contents | NAD+: 1500 mg per 3 mL pen; 300 mg per 3 mL pen (50% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-115 |
What is in the pen
The cartridge holds a sterile aqueous solution of oxidized NAD+ free acid at 50% w/v, which is 500 mg/mL and 1,500 mg across the 3 mL. From the theoretical mass of 663.4 Da that comes to roughly 0.75 M, or about 2.3 mmol per pen. The solvent is bacteriostatic water with 0.9% benzyl alcohol as a preservative. The safety data sheet classifies benzyl alcohol as harmful if swallowed or inhaled, a serious eye irritant and a skin sensitiser, and lists NAD+ itself as not classified.
Store the pen at 2 to 8 °C in its carton, protected from light, and keep it capped between uses. Do not let it freeze, and discard it if the solution has frozen, changed colour or gone cloudy. The NAD+ 100 mg/mL pen holds the same compound at a fifth of the strength, and peptide pen vs vial sets out the general trade-offs between formats.
What the research covers
Inside cells NAD+ works in two ways. Redox enzymes use it to carry electrons from one reaction to another, and enzymes such as the sirtuins and PARPs use it as a cosubstrate1. Cantó, Menzies and Auwerx described it as a cofactor able to rewire metabolism, activate sirtuins and keep mitochondria fit, partly through the mitochondrial unfolded protein response, and as a link between a cell’s energy status and its adaptive responses2. Rajman’s group described NAD+ as a signalling molecule as well as a hydrogen carrier, read by NAD+-sensing enzymes that control hundreds of processes3. Levels are not constant. They move with food intake, exercise and time of day, and fall steadily with age, a decline that a 2018 review tied to altered metabolism and greater susceptibility to disease3. The same review reported that restoring NAD+ in old or diseased animals promoted health and extended lifespan, and it presented this as the start of a search for safe NAD-boosting molecules rather than a settled result3.
None of that work used a concentrated NAD+ solution or a pen, and the abstracts say nothing about how stable NAD+ is in water. No controlled human trial of NAD+ itself is among the references cited here. The NAD+ guide covers the literature in full.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How does this pen differ from the 100 mg/mL NAD+ pen?
Only in strength. Both carry a 3 mL cartridge of NAD+ in bacteriostatic water with 0.9% benzyl alcohol. This one is at 500 mg/mL, 1,500 mg per pen; the other is at 100 mg/mL, 300 mg per pen. Storage is the same for both: cold, dark and never frozen.
What does the certificate cover for a pen?
It covers the NAD+ lot used to fill the pen, tested in PrymaLab's own laboratory, not the finished solution in the cartridge. The testing section on this page explains how to find published certificates and verify them by number and key.
Why would a lab pick a pen over the NAD+ vials?
The vials hold dry powder that is kept frozen and dissolved at whatever concentration a study needs. The pen arrives as a fixed, ready solution that is kept refrigerated. Dry powder keeps the compound out of water until it is needed; the pen gives that up for convenience.
Is the pen for human use?
No. It is a laboratory research product only. It is not approved by the FDA or any other authority for human or veterinary use, and nothing on this page is guidance for using it in people or animals.
References
- Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-13. DOI · PubMed
- Cantó C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015;22(1):31-53. DOI · PubMed
- Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018;27(3):529-547. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of NAD+ (injectable)
NAD+ (injectable) is also stocked as NAD+ 500mg, NAD+ 1000mg and NAD+ Nasal Spray. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
4 reviews for Preloaded Autoinjector | NAD+ (injectable) | 3ml Pen | 500mg/ml