Description
PrymaLab · Research use only
Preloaded Autoinjector | KLOW Blend | 3ml Pen | 80mg/ml
KLOW pen: GHK-Cu, BPC-157, TB-500 and KPV in solution, 80 mg/mL in a 3 mL pen
The KLOW pen is PrymaLab’s four-peptide KLOW blend supplied as a solution rather than a powder: GHK-Cu, BPC-157, thymosin beta-4 (TB-500) and KPV, dissolved together at 80 mg/mL in a preloaded 3 mL pen. Each of the four has its own research literature, on matrix repair, blood vessel growth, actin and inflammation. None of that work tested the four together, in a pen or in any other form.
Specifications
| Property | Value |
|---|---|
| Components | GHK-Cu (Copper tripeptide-1; Gly-His-Lys · Cu(II)) BPC-157 (Body Protection Compound-157; pentadecapeptide) TB-500 (Thymosin β4); N-acetyl thymosin β4, full-length 43-residue peptide KPV (Lys-Pro-Val; α-MSH(11–13)) |
| GHK-Cu CAS number | 89030-95-5 |
| BPC-157 CAS number | 137525-51-0 |
| TB-500 (Thymosin β4) CAS number | 77591-33-4 |
| KPV CAS number | 67727-97-3 |
| Contents | GHK-Cu: 150 mg per 3 mL pen (5% w/v) BPC-157: 30 mg per 3 mL pen (1% w/v) TB-500 (Thymosin β4): 30 mg per 3 mL pen (1% w/v) KPV: 30 mg per 3 mL pen (1% w/v) |
| Form | Sterile aqueous solution in bacteriostatic water (0.9% benzyl alcohol), supplied in a 3 mL glass cartridge inside a preloaded autoinjector pen fitted with a needle |
| Storage, sealed | Store at 2–8 °C in the original carton, protected from light |
| Safety data sheet | PL-SDS-096 |
What is in the KLOW pen
The safety data sheet for the KLOW peptide pen (PL-SDS-096) gives the contents of each 3 mL cartridge: GHK-Cu 150 mg (5% w/v), with BPC-157, TB-500 and KPV at 30 mg each (1% w/v). That is 240 mg of peptide, or 80 mg/mL, in the same 5:1:1:1 mass ratio as the 80 mg vial. The solvent is bacteriostatic water containing 0.9% benzyl alcohol, which the sheet classifies as harmful if swallowed or inhaled, an eye irritant and a possible skin sensitiser; none of the four peptides is classified. The copper complex makes the solution clear blue to blue-violet.
Keep the pen in its carton at 2 to 8 °C, away from light and capped between uses, and never let it freeze. Discard it if the solution has frozen, changed colour or turned cloudy. The freeze-dried KLOW Blend 80 mg vial holds the same four peptides for work that needs its own concentration.
What the research covers
The pen’s four components come from unrelated research areas. GHK-Cu is a copper-binding plasma peptide that a 2018 review credits with stimulating collagen, elastin and glycosaminoglycan synthesis and the outgrowth of blood vessels and nerves, and with tissue repair in skin, lung connective tissue, bone, liver and stomach lining1. Thymosin beta-4, the full-length molecule sold here as TB-500, binds actin and promotes cell migration; a 2012 review described it as released by platelets and macrophages after injury and as lowering myofibroblast numbers and scarring in wounds2. The clinical trials that review mentions were ongoing or planned, and it reports no outcomes2. KPV, a three-residue fragment of alpha-MSH, blocked NF-κB and MAP kinase signalling at nanomolar concentrations in human intestinal and T cell lines3. The rat and cell studies on BPC-157 are summarised on the KLOW Blend 80 mg vial page.
All of this is component research, mostly in cells and animals. No study has put the four peptides in one solution, so nothing has been published on whether they stay stable together, whether the copper complex affects the others, or whether a combined effect exists. The KLOW peptide guide covers each component’s literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. The certificate covers the peptide lot used to fill the pen, not the finished solution. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
How is the KLOW pen different from the KLOW vial?
The vial holds 80 mg of the four peptides as freeze-dried powder, stored at −20 °C and dissolved in the lab. The KLOW pen holds 240 mg of the same four, already dissolved at 80 mg/mL in bacteriostatic water and kept at 2 to 8 °C. The 5:1:1:1 mass ratio is the same in both.
What does the certificate cover for the KLOW pen?
The certificate covers the peptide lot used to fill the pen, tested in PrymaLab's own laboratory. It is not a test of the finished solution in the cartridge. The testing section on this page explains what is measured and where certificates can be checked.
Has anyone studied these four peptides together in solution?
No published study has. Each component has its own literature, but nothing has been reported on the four combined: not their stability in one solution, not any interaction with the copper complex, and not any combined biological effect.
Is the KLOW pen for human use?
No. Like every PrymaLab product it is sold for laboratory research only. It has no FDA or other approval for human or veterinary use and must not be used on people or animals.
References
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7). DOI · PubMed
- Goldstein AL, Hannappel E, Sosne G, et al. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. DOI · PubMed
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-78. DOI · PubMed
Research use only
For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
31 reviews for Preloaded Autoinjector | KLOW Blend | 3ml Pen | 80mg/ml