Description
PrymaLab · Research use only
NAD+ 500mg
NAD+ free acid, 500 mg of dry powder, the smaller of the two vial fills
NAD+ is nicotinamide adenine dinucleotide in its oxidized form, a coenzyme built from two nucleotides and not a peptide. This vial holds 500 mg of the free acid as a white powder, half the main fill. Published work on NAD+ looks at how cells use it to move electrons, how sirtuins and PARPs consume it, and why its level drops with age in animal studies.
Specifications
| Property | Value |
|---|---|
| Compound | NAD+ β-Nicotinamide adenine dinucleotide, oxidized (free acid); coenzyme, not a peptide |
| CAS number | 53-84-9 |
| Molecular formula | C21H27N7O14P2 |
| Theoretical mass | 663.4 Da |
| Sequence / structure | Dinucleotide: adenosine 5′-monophosphate joined through a pyrophosphate bridge to nicotinamide 5′-mononucleotide; oxidized form. |
| Label claim | 500 mg/vial |
| Form | Crystalline or amorphous powder in a sealed glass vial |
| Storage, sealed | −20 °C, tightly sealed, dry, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-114 |
Other fills
This is the 500 mg fill. The NAD+ 1000mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 1000 mg.
What the research covers
Rajman and colleagues called NAD the cell’s hydrogen carrier for redox enzymes and described its newer role as a signal, with NAD+-sensing enzymes governing processes from energy metabolism to cell survival1. They reported that NAD+ declines steadily with age and that restoring it promoted health and extended lifespan in old or diseased animals1. Much of that restoring was done with the precursors NMN and NR, whose translation to people was still to be tested in 20182. The NAD+ 1000 mg vial page has the full research summary.
The NAD+ Peptide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is this the same NAD+ as the 1,000 mg vial?
Yes. Both hold oxidized NAD+ as the free acid, CAS 53-84-9, with a theoretical mass of 663.4 Da. The 500 mg fill is a separate lot, so it carries its own lot number and certificate, shown in the panel on this page.
What is 500 mg in molar terms?
About 754 µmol, using the certificate's theoretical mass of 663.4 Da. The real figure is slightly lower because the powder holds a little residual water, which the certificate reports as a percentage.
How should the vial be kept?
Sealed at −20 °C, dry and away from light, which is the storage line on the certificate. Let it warm up before the seal is broken. Solutions belong in the refrigerator, shielded from light, for no longer than your laboratory has shown to be acceptable.
References
- Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018;27(3):529-547. DOI · PubMed
- Yoshino J, Baur JA, Imai SI. NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27(3):513-528. DOI · PubMed
Research use only
For laboratory research use only. NAD+ 500mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of NAD
NAD is also stocked as NAD+ Nasal Spray, NAD+ (injectable) 500mg/ml preloaded 3ml pen and NAD+ 100mg/ml preloaded 3ml pen. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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