Description
PrymaLab · Research use only
Thyroidget (Asp-Trp) Peptide 100mg
Asp-Trp (DW), the Khavinson-line thyroid dipeptide, 100 mg freeze-dried
Thyroidget is the name the St Petersburg Institute of Bioregulation and Gerontology gives to the dipeptide Asp-Trp (DW), listed in its tables of ultrashort peptides with the activity ‘thyroid regulator’. It belongs to the newer two-residue ‘-get’ series alongside Retiget, Vesselget and Kistiget. This listing is the 100 mg vial of freeze-dried powder, the only fill. The peer-reviewed record on this particular dipeptide is two developer reviews and no experimental thyroid data, which this page says plainly.
Specifications
| Property | Value |
|---|---|
| Compound | Thyroidget (DW), L-aspartyl-L-tryptophan; Khavinson synthetic ultrashort bioregulator dipeptide |
| CAS number | 71835-79-5 (L-aspartyl-L-tryptophan) |
| Molecular formula | C15H17N3O5 |
| Theoretical mass | 319.3 Da |
| Sequence / structure | H-Asp-Trp-OH (DW); dipeptide, all L, free termini. |
| Label claim | 100 mg per vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Certificate for the first lot: in preparation. Published certificates appear on the results page and can be checked on the verify page. |
What the structure is
H-Asp-Trp-OH: two L-amino acids, free termini, no modifications. Formula C15H17N3O5, theoretical mass 319.3 Da (PubChem CID 7020001, CAS 71835-79-5 for the dipeptide; the trade name itself has no registry entry). Two carboxyls make it acidic and readily water-soluble; the tryptophan indole makes it light- and oxidation-sensitive, and old solutions yellow.
Three Khavinson-school thyroid products are routinely conflated. Thyreogen is a peptide complex extracted from calf thyroid, sold in capsules; Thyramin is a nucleoprotein tablet from cattle thyroid; Thyroidget is this defined synthetic dipeptide. A certificate showing a single peak at about 319 Da identifies the dipeptide; a broad multi-peak profile would mean an extract. Testagen (Lys-Glu-Asp-Gly), which a 2008 Russian patent links to TSH, is an unrelated peptide.
What the research covers
What the developers have published on DW
The only peer-reviewed mentions of Thyroidget found are in the developers’ own reviews. A 2022 review tabulates ‘Thyroidget (DW)’ as a ‘thyroid regulator’ in a list of ultrashort peptides whose binding to the amino-acid transporter LAT1 was estimated by docking; DW received an ICM-Score of -12.12, weaker than most of the group’s tri- and tetrapeptides and weaker than the -15 threshold the authors take to indicate probable transport by LAT11. A 2023 docking study of 26 of the group’s peptides included DW among ligands modelled against LAT1, LAT2, PEPT1 and PEPT2 and reported that, as a set, the biologically active peptides scored better than random di- and tripeptides, but it gives no DW-specific experimental result2. No cell, animal or human study of Asp-Trp on thyroid cells, thyroid hormones or TSH was found in PubMed/Europe PMC.
Class context: Khavinson short peptides (not DW-specific data)
The developers’ framework holds that 2-7-residue peptides enter cells, bind DNA and histones, and tissue-specifically regulate gene expression; their 2021 systematic review collects such data for peptides including AEDG (Epitalon), EDR (Pinealon), KE, EW and KEDG, with DNA-binding, histone-binding and differentiation experiments mostly from the same institute3. DW itself is not among the peptides with reported gene-expression or histone-binding data in that review3. The thyroid claims for the family therefore rest on the extract products rather than on the dipeptide.
Thyroid extract bioregulator in elderly residents of Magadan (Thyramin, not DW)
The one indexed clinical report on a Khavinson thyroid bioregulator concerns Thyramin, a tablet made from cattle thyroid, given to residents of the Magadan region with reduced thyroid function; the English abstract states only that Thyramin exerts a tissue-specific effect on thyroid cells and ‘enables restoration’ of disturbed thyroid function, without reporting numbers, group sizes or design4. The paper is in Russian, authored with Khavinson, has no DOI and does not involve Asp-Trp4.
What is not established
There is no primary pharmacology for Asp-Trp as a thyroid regulator: no published in vitro thyrocyte study, no animal study of TSH, T3 or T4, no pharmacokinetics and no clinical trial were found; the ‘thyroid regulator’ label rests on a single developer-authored table entry1. All Khavinson-school thyroid data are from the group’s own extract products (Thyramin, Thyreogen) and appear in Russian-language journals or patents, without independent replication4. The proposed mechanisms for the peptide family (DNA/histone binding, LAT/PEPT transport) are largely docking predictions and in-house experiments on other peptides1,2,3. The identity of the material behind the price-list name has not been verified. None of the published work used this supplier’s material.
Clinical and regulatory status
No drug approval found in any jurisdiction for Asp-Trp or for ‘Thyroidget’; it is not listed in the Russian drug register as a medicine (the developers’ 2022 table marks only Thymogen (EW) as a ‘medicinal product’ among the dipeptides)1. The related Russian products Thyreogen and Thyramin are sold as dietary supplements, not drugs. No ClinicalTrials.gov entry exists for Thyroidget, Asp-Trp or Thyreogen. This listing is a research-grade material.
Related listings: Testagen Peptide 20mg, Thymogen Peptide 20mg, Vilon Peptide 20mg, Pancragen Peptide 20mg, Epitalon 10mg. The peptide bioregulators category lists the rest of the range.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. Published certificates are listed on the results page and can be checked by number and key on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
What is Thyroidget chemically?
According to its developers, Thyroidget is the dipeptide Asp-Trp (DW), H-Asp-Trp-OH, C15H17N3O5, 319.31 Da, PubChem CID 7020001, CAS 71835-79-5. It is one of the Khavinson-line synthetic ‘ultrashort peptides’, in the same family as Vilon (KE) and Thymogen (EW).
Is Thyroidget the same as Thyreogen or Thyramin?
No. Thyreogen is a peptide complex extracted from calf thyroid (capsules), Thyramin is a nucleoprotein tablet from cattle thyroid, and Thyroidget is a defined synthetic dipeptide. Vendors sometimes use the names interchangeably, so check the certificate of analysis: a single peak at about 319 Da indicates Asp-Trp; a broad mixture indicates an extract.
What does the literature show for Thyroidget?
Very little. The only indexed sources are two developer reviews that list DW as a ‘thyroid regulator’ and model its docking to amino-acid and peptide transporters. No experimental thyroid data for Asp-Trp were found.
How does it differ from Testagen (KEDG), which is also linked to thyroid function?
Testagen is the tetrapeptide Lys-Glu-Asp-Gly, which a 2008 Russian patent by Kuznik, Khavinson and colleagues claims as a stimulator of TSH and thyroid hormone synthesis. Thyroidget is the unrelated dipeptide Asp-Trp. They share no sequence and the patent data do not transfer.
Why is the vial 100 mg?
That is the supplier’s fill size, not a literature-derived quantity. For a 319 Da dipeptide 100 mg is about 313 micromoles. Large fills are more typical of extract products, which is one reason the identity should be confirmed by COA.
How should it be stored?
Lyophilized, sealed at −20 °C, desiccated and in the dark; the tryptophan indole is sensitive to light and oxidation. Reconstituted solutions should be kept at 2 to 8 °C and used within days, or frozen in aliquots.
References
- Khavinson V, Linkova N, Kozhevnikova E, Dyatlova A, Petukhov M. Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers. Int J Mol Sci. 2022;23(14):7733. DOI · PubMed
- Khavinson VK, Linkova NS, Rudskoy AI, Petukhov MG. Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters. Biomolecules. 2023;13(3):552. DOI · PubMed
- Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. DOI · PubMed
- Gorbachev AL, Lugovaia EA, Ryzhak GA, Khavinson VKh. [Peptide bioregulator efficacy in the correction of reduced thyroid gland function in the residents of Magadan Region] (Russian). Adv Gerontol (Uspekhi Gerontologii). 2005;16:80-87. PubMed
Research use only
For laboratory research use only. Thyroidget (Asp-Trp) Peptide 100mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
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