Description
PrymaLab · Research use only
HCG 5000iu
Human chorionic gonadotropin, 5,000 IU of urinary hCG as a freeze-dried cake
Human chorionic gonadotropin is the placental glycoprotein hormone, a pairing of an alpha subunit shared with LH, FSH and TSH and a beta subunit unique to hCG. This vial contains 5,000 IU of urinary hCG, about 0.5 mg of glycoprotein according to the certificate, freeze-dried as a white cake. It holds half the activity of the 10,000 IU main fill and has its own lot and certificate. Studies of hCG concern its glycosylated forms and the standards built to measure them.
Specifications
| Property | Value |
|---|---|
| Compound | HCG Human chorionic gonadotropin (urinary); potency assigned in IU by bioassay |
| CAS number | 9002-61-3 |
| Molecular formula | Not applicable (glycoprotein) |
| Theoretical mass | About 36–38 kDa glycoform average; 25.7 kDa protein core (about 30% carbohydrate) |
| Sequence / structure | Non-covalent heterodimer, 237 residues in total: common glycoprotein-hormone α-subunit (92 aa) paired with the hCG β-subunit (145 aa, including the 24-residue C-terminal peptide); 11 disulfides; N- and O-glycosylated. |
| Label claim | 5,000 IU/vial (≈ 0.5 mg glycoprotein, standardized by bioassay) |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | 2–8 °C, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-077 |
Other fills
This is the 5000 IU fill. The HCG 10000iu page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 10000 IU.
What the research covers
The beta subunit is what sets hCG apart from the other glycoprotein hormones: it decides receptor and biological specificity, and in hCG it carries two N-linked and four O-linked glycosylation sites1. The hormone also circulates in more than one form. Cole listed regular hCG, a hyperglycosylated variant made by invasive trophoblast cells, and the free beta-subunit of that variant2. The HCG 10,000 IU page carries the full research summary, including the reference reagents used to standardize hCG assays and what an international unit measures.
The HCG Peptide guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is this the same hCG as the 10,000 IU vial?
Yes. Both are urinary human chorionic gonadotropin with potency set by bioassay; this fill carries half the activity, roughly 0.5 mg of glycoprotein. It is produced and tested as a separate lot, so its lot number and certificate differ from those of the larger vial.
How should the 5,000 IU vial be stored?
Sealed, at 2 to 8 °C and away from light, as the certificate specifies for this glycoprotein. Bring it to room temperature before opening to keep condensation off the cake. Any solution made from it is held at 2 to 8 °C, protected from light, for a period set by your laboratory.
Is it for human or veterinary use?
No. It is a laboratory research material, not approved by any regulator for use in people or animals, and it must not be given to either.
References
- Fournier T, Guibourdenche J, Evain-Brion D. Review: hCGs: different sources of production, different glycoforms and functions. Placenta. 2015;36 Suppl 1:S60-5. DOI · PubMed
- Cole LA. New discoveries on the biology and detection of human chorionic gonadotropin. Reprod Biol Endocrinol. 2009;7:8. DOI · PubMed
Research use only
For laboratory research use only. HCG 5000iu is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
Other formats of HCG
HCG is also stocked as hMG (Menotropins) 150IU preloaded 3ml pen and HMG 75IU. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
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