Description
PrymaLab · Research use only
P21 (P021) 5mg
P021, the CNTF-derived DGGL-adamantane peptidomimetic, 5 mg freeze-dried
P21 (P021) is a CNTF-derived peptidomimetic: the acetylated tetrapeptide Asp-Gly-Gly-Leu with a 3-aminoadamantane-1-carboxamide group on its C-terminus, theoretical mass 578.7 Da. This is the 5 mg vial of freeze-dried powder, half the 10 mg main fill, with its own lot and the certificate shown on this page. Studies of P021 have measured neurogenesis, BDNF and tau in aged rats and Alzheimer’s model mice.
Specifications
| Property | Value |
|---|---|
| Compound | P21 (P021) Ac-DGGL coupled to 3-aminoadamantane-1-carboxamide; CNTF-derived peptidomimetic |
| CAS number | 1246751-68-7 |
| Molecular formula | C27H42N6O8 |
| Theoretical mass | 578.7 Da |
| Sequence / structure | Ac-DGGL-NH-(3-carbamoyladamantan-1-yl): the tetrapeptide Ac-Asp-Gly-Gly-Leu amidated at its C-terminus with 3-aminoadamantane-1-carboxamide; N-acetyl; no disulfides. |
| Label claim | 5 mg/vial |
| Form | Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap |
| Storage, sealed | −20 °C, desiccated, dark |
| Purity specification | 99.0% or higher by RP-HPLC |
| Lot certificate | Results for the lot now shipping are in the certificate panel on this page |
| Safety data sheet | PL-SDS-124 |
Other fills
This is the 5 mg fill. The P21 (P021) 10mg page is the main listing for this compound, with the full research summary and every fill side by side. Other fills: 10 mg.
What the research covers
In aged Fisher rats, P021 reduced the age-related decline in learning and memory, raised BDNF and offset the drop in neurogenesis1. In 3xTg-AD mice it lowered tau hyperphosphorylation and soluble amyloid-beta over a 12-month study2. All of this work comes from one research group, and there are no human data. The P21 (P021) 10 mg page has the full research summary.
The P21 Peptide (P021) guide covers the literature in more depth.
How each lot is tested
Every lot is tested in PrymaLab’s own laboratory in Ashland, Kentucky before release: RP-HPLC for purity, LC-MS for identity, Karl Fischer titration for water, LAL for endotoxin and USP <71> for sterility. The results for the lot now shipping are in the certificate panel on this page, and the certificate number, key and QR code can be checked on the verify page. These are in-house results from PrymaLab Analytical, not an independent test, and the lab is not accredited to ISO 17025. The third-party testing guarantee on this page still applies: if any independent laboratory finds the wrong compound, or less than the stated purity or amount, the order is refunded and the cost of the test is reimbursed.
Frequently asked questions
Is the 5 mg vial the same compound as the 10 mg?
Yes. Both hold Ac-DGGL amidated with 3-aminoadamantane-1-carboxamide, C27H42N6O8, 578.7 Da. This fill holds about 8.6 µmol, and its lot is certified separately; the panel on this page shows the lot now shipping.
How should the vial be stored?
Sealed at −20 °C, desiccated and protected from light. Let it reach room temperature before opening so moisture does not condense on the powder, and keep any reconstituted solution at 2 to 8 °C, away from light.
References
- Bolognin S, Buffelli M, Puoliväli J, et al. Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound. Neurobiol Aging. 2014;35(9):2134-46. DOI · PubMed
- Kazim SF, Blanchard J, Dai CL, et al. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2014;71:110-30. DOI · PubMed
Research use only
For laboratory research use only. P21 (P021) 5mg is not a drug, food, cosmetic or dietary supplement, is not approved by the FDA or any comparable authority for human or veterinary use, and must not be given to people or animals. It is sold to qualified researchers and institutions, and the buyer is responsible for lawful handling and disposal.
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