PrymaLab AnalyticalSafety data sheet ยท lyophilized powder, vialPrymaLab LLC ยท 3705 Music Branch Rd, Ashland, KY 41102
Document number
PL-SDS-009
Revision
1.0 ยท Oct 3, 2026
AICAR Lyophilized powder, vial ยท 1 catalogue item
For laboratory research use only. Not for human or veterinary use; not a drug, food, dietary supplement, cosmetic or household product.
1Identification
| Product identifier | AICAR โ lyophilized powder, vial |
|---|---|
| Catalogue items covered | AICAR 50MG PL-AICAR-50MG-VIAL |
| Synonyms / chemical names | AICAR: Acadesine; 5-aminoimidazole-4-carboxamide-1-ฮฒ-D-ribofuranoside; nucleoside, not a peptide (CAS 2627-69-2) |
| Recommended use | Laboratory research chemical for in-vitro and animal-model studies by trained personnel. |
| Restrictions on use | Not for human or veterinary use, diagnosis or therapy. Not for use as a drug, food, dietary supplement, cosmetic or in household products. Not for resale to the public for personal use. |
| Supplier | PrymaLab LLC (PrymaLab Analytical), 3705 Music Branch Rd, Ashland, KY 41102, United States ยท Tel. +1 (606) 465-9063 ยท michael@prymalab.net ยท https://prymalab.net |
| Emergency telephone | Poison Help (US, 24 h): 1-800-222-1222 ยท Supplier (business hours, US Eastern): +1 (606) 465-9063 |
2Hazard(s) identification
Classification of the substance
- Skin corrosion/irritation, Category 2 โ H315
- Serious eye damage/eye irritation, Category 2A โ H319
- Specific target organ toxicity, single exposure (respiratory tract irritation), Category 3 โ H335
Label elements
GHS07 โ Exclamation mark
Signal word: Warning
Hazard statements
H315Causes skin irritation.H319Causes serious eye irritation.H335May cause respiratory irritation.
Precautionary statements
Prevention
P261Avoid breathing dust, mist or spray.P264Wash hands and any exposed skin thoroughly after handling.P271Use only outdoors or in a well-ventilated area.P280Wear protective gloves, protective clothing and eye protection.
Response
P302+P352IF ON SKIN: Wash with plenty of water.P304+P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P312Call a POISON CENTER or doctor if you feel unwell.P321Specific treatment: see Section 4 of this safety data sheet.P332+P313If skin irritation occurs: Get medical advice/attention.P337+P313If eye irritation persists: Get medical advice/attention.P362+P364Take off contaminated clothing and wash it before reuse.
Storage
P403+P233Store in a well-ventilated place. Keep container tightly closed.P405Store locked up.
Disposal
P501Dispose of contents and container to an approved waste disposal plant in accordance with local, state and federal regulations.
Hazards not otherwise classified / other hazards
- Pharmacologically active material. Accidental injection, ingestion or absorption may produce systemic effects consistent with the compound's mechanism of action; see Section 11.
- Finely divided organic powder may form combustible dust concentrations in air if dispersed in bulk (not expected at laboratory scale).
3Composition / information on ingredients
Lyophilized (freeze-dried) powder or cake in a sealed glass vial with a rubber stopper and aluminium crimp cap.
| Ingredient | CAS No. | Formula | Concentration | Quantity | Ingredient classification |
|---|---|---|---|---|---|
| AICAR Acadesine; 5-aminoimidazole-4-carboxamide-1-ฮฒ-D-ribofuranoside; nucleoside, not a peptide | 2627-69-2 | C9H14N4O5 | โฅ 95% (dry basis, as supplied) | 50 mg per vial | Skin irrit. 2 ยท H315 Eye irrit. 2A ยท H319 STOT SE 3 ยท H335 |
Peptides are supplied as the acetate or trifluoroacetate salt unless stated otherwise; the counter-ion and residual water make up the balance of a lyophilized product. Concentration limits used for mixture classification follow OSHA HCS 2012 Appendix A.
4First-aid measures
| Inhalation | Move the person to fresh air and keep comfortable for breathing. If breathing is difficult or symptoms persist, call a POISON CENTER or doctor. |
|---|---|
| Skin contact | Take off contaminated clothing. Wash the skin with plenty of soap and water. If irritation or a rash develops, get medical advice. |
| Eye contact | Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do; continue rinsing. If eye irritation persists, get medical advice. |
| Ingestion | Rinse mouth. Do not induce vomiting. Call a POISON CENTER or doctor if you feel unwell. |
| Most important symptoms and effects | Skin redness or irritation; eye redness, watering and irritation; coughing and irritation of the nose and throat after inhaling dust. |
| Indication of immediate medical attention | Treat symptomatically. Show this safety data sheet to the attending physician. No specific antidote is known; monitor for the effects described in Section 11. |
5Fire-fighting measures
| Suitable extinguishing media | Water spray, carbon dioxide, dry chemical or alcohol-resistant foam. Use measures appropriate to the surrounding fire. |
|---|---|
| Unsuitable extinguishing media | None known. Do not use a high-pressure water jet on powders (dust dispersion). |
| Specific hazards | Combustible organic solid; finely divided powder may form dust clouds. Not flammable in the quantities supplied. Thermal decomposition may release carbon monoxide, carbon dioxide and nitrogen oxides. |
| Protective equipment for fire-fighters | Self-contained breathing apparatus and full protective clothing. Prevent run-off from entering drains. |
6Accidental release measures
| Personal precautions | Wear the protective equipment in Section 8. Keep unprotected people away. Avoid dust formation and inhalation of dust. |
|---|---|
| Environmental precautions | Do not allow material to reach drains, surface water or soil. Quantities supplied are small; collect for disposal. |
| Methods for cleaning up | Avoid dust formation. Dampen spilled powder with water, wipe up with absorbent material, place in a sealed container for disposal and clean the area with water and detergent. Decontaminate surfaces with 70% alcohol or detergent and water. |
7Handling and storage
| Precautions for safe handling | Open vials only in a clean area. Avoid generating or inhaling dust; weigh or reconstitute inside a ventilated enclosure when the full contents are handled as a dry powder. Reconstitute by adding diluent slowly to the vial wall; do not shake. Wash hands after handling. Do not eat, drink or smoke in the handling area. Follow the precautionary statements in Section 2. |
|---|---|
| Conditions for safe storage | Store the sealed vial at the temperature stated in Section 9 (typically โ20 ยฐC for peptides, 2โ8 ยฐC for proteins), desiccated and protected from light. Allow the vial to reach room temperature before opening to avoid condensation. Reconstituted solutions: 2โ8 ยฐC, protected from light; use within the period established by your laboratory. Keep the container tightly closed and labelled, out of reach of unauthorised persons (store locked up). |
| Storage temperature | โ20 ยฐC (sealed vial), desiccated and protected from light; 2โ8 ยฐC acceptable for short periods |
| Incompatible materials | Strong oxidising agents, strong acids and bases. |
8Exposure controls / personal protection
| Occupational exposure limits | No occupational exposure limits (OSHA PEL, ACGIH TLV, NIOSH REL) have been established for any ingredient. |
|---|---|
| Engineering controls | Good general laboratory ventilation. Weigh or manipulate dry powder in a ventilated enclosure (powder hood, biosafety cabinet or fume hood). An eyewash station should be available. |
| Eye / face protection | Safety glasses with side shields (ANSI Z87.1 / EN 166). |
| Skin protection | Nitrile gloves (inspect before use; change after contamination) and a laboratory coat. |
| Respiratory protection | Not normally required with the engineering controls above. Where dust cannot be controlled, use a NIOSH-approved N95 (or P2) particulate respirator. |
| Hygiene measures | Wash hands after handling and before breaks. Remove contaminated clothing. Do not pipette by mouth. |
9Physical and chemical properties
| Physical state / appearance | Solid. White to off-white crystalline powder. |
|---|---|
| Odour / odour threshold | Characteristic (Cayman); odor threshold not determined |
| pH | Not applicable (solid); aqueous solutions typically pH 4โ7 |
| Melting / freezing point | 212 ยฐC (TCI); 214-215 ยฐC (ChemicalBook); Cayman: undetermined |
| Boiling point | Undetermined |
| Flash point / flammability | Not applicable (non-flammable solid); combustible organic material |
| Vapour pressure / density | Negligible (solid) |
| Relative density | No data available (bulk density of lyophilized cake is low) |
| Solubility | Cayman: DMF 10 mg/ml; DMSO 20 mg/ml; ethanol 1 mg/ml; PBS pH 7.2 2.5 mg/ml. ChemicalBook: water >10 mg/ml |
| Partition coefficient (log Pow) | No data available |
| Auto-ignition / decomposition temperature | No data available; peptides decompose above about 200 ยฐC |
| Molecular formula / mass | AICAR: C9H14N4O5, 258.2 g/mol |
| Other information | Not flammable (Cayman). Specific rotation -61.0 to -66.0ยฐ (c=1, H2O) (TCI). Heat sensitive; store frozen (TCI). MW 258.2, C9H14N4O5 |
10Stability and reactivity
| Reactivity | No hazardous reactivity under normal laboratory conditions. |
|---|---|
| Chemical stability | Stable when stored as recommended (Section 7). Lyophilized peptides are hygroscopic and degrade faster once moist or reconstituted. |
| Possibility of hazardous reactions | None known. |
| Conditions to avoid | Heat, direct light, moisture, repeated freezeโthaw cycles. |
| Incompatible materials | Strong oxidising agents, strong acids and bases. |
| Hazardous decomposition products | Carbon oxides and nitrogen oxides on combustion. No hazardous decomposition under recommended storage. |
11Toxicological information
Likely routes of exposure: Inhalation of dust, skin and eye contact when the vial is opened or the powder is weighed; ingestion through contaminated hands; accidental injection when reconstituted solutions are drawn into syringes.
Symptoms related to the physical, chemical and toxicological characteristics: Skin redness or irritation; eye redness, watering and irritation; coughing and irritation of the nose and throat after inhaling dust.
AICAR Acadesine; 5-aminoimidazole-4-carboxamide-1-ฮฒ-D-ribofuranoside; nucleoside, not a peptide ยท CAS 2627-69-2
Substance classification adopted: Skin irrit. 2 ยท H315 Eye irrit. 2A ยท H319 STOT SE 3 ยท H335
Cayman Chemical SDS (acadesine). TCI omits H335; the more conservative Cayman set is adopted.
| Acute toxicity, oral | No data available (no LD50 in Cayman, TCI or ChemicalBook SDS) |
|---|---|
| Acute toxicity, dermal | No data available |
| Acute toxicity, inhalation | No data available |
| Skin corrosion/irritation | Irritant to skin and mucous membranes (Cayman); classified Skin Irrit. 2 |
| Serious eye damage/irritation | Irritating effect (Cayman); classified Eye Irrit. 2A |
| Respiratory or skin sensitisation | No sensitizing effects known (Cayman) |
| Germ cell mutagenicity | No data available |
| Carcinogenicity | Not listed by IARC, NTP or OSHA (Cayman) |
| Reproductive toxicity | No data available |
| STOT, single exposure | May cause respiratory irritation (Category 3) per Cayman and ChemicalBook; TCI does not carry H335 |
| STOT, repeated exposure | No data available |
| Aspiration hazard | No data available |
- WADA Prohibited List class S4.4 (metabolic modulators).
Carcinogen listings: no ingredient is listed as a carcinogen by IARC, NTP or OSHA.
12Ecological information
AICAR: Cayman: Water hazard class 1 (self-assessment), slightly hazardous for water; no aquatic toxicity, persistence or bioaccumulation data available. Do not allow undiluted product to reach ground water or sewage.
Persistence and degradability: peptides and amino acids are expected to biodegrade readily; benzyl alcohol is readily biodegradable (92โ96% in 14 days, OECD 301C). Bioaccumulative potential: low (hydrophilic, log Pow < 3 where known). Mobility in soil: water-soluble; mobile. PBT/vPvB: not expected to meet the criteria. Other adverse effects: none known. Do not release concentrated material to the environment.
13Disposal considerations
Dispose of unused material and contaminated packaging through a licensed chemical-waste contractor in accordance with federal (40 CFR 261), state and local regulations; the material is not a listed RCRA hazardous waste but is classified as hazardous for supply and should be managed as chemical waste. Do not pour down the drain. Small residues may be inactivated with 10% bleach for 30 minutes before disposal where local rules allow. Empty glass vials and cartridges: remove labels or deface them before recycling or disposal.
14Transport information
| DOT (49 CFR) / IATA / IMDG | Not regulated as a dangerous good for transport by road (DOT 49 CFR), air (IATA/ICAO) or sea (IMDG). Not a marine pollutant. Ship refrigerated or frozen as required by Section 7; the coolant (dry ice, UN 1845) is regulated when used. |
|---|---|
| UN number / proper shipping name / class / packing group | Not applicable. |
15Regulatory information
| OSHA Hazard Communication Standard (29 CFR 1910.1200) | Hazardous: Skin corrosion/irritation (Category 2); Serious eye damage/eye irritation (Category 2A); Specific target organ toxicity, single exposure (respiratory tract irritation) (Category 3). |
|---|---|
| TSCA (Toxic Substances Control Act) | AICAR: listed on the TSCA Inventory. |
| SARA Title III (Sections 302, 311/312, 313), CERCLA | No ingredient is listed as an extremely hazardous substance (Section 302), a Section 313 toxic chemical or a CERCLA hazardous substance. Section 311/312 hazard categories follow the classification in Section 2. |
| California Proposition 65 | No ingredient is listed as known to the State of California to cause cancer or reproductive toxicity. |
| State right-to-know lists | No ingredient is listed. |
| US FDA | Research chemical. Not an FDA-approved drug product; not evaluated for safety or efficacy in humans or animals; not GRAS; not a dietary ingredient. Sold for laboratory research use only. |
| US DEA controlled substances | No ingredient is scheduled under the Controlled Substances Act at the revision date. |
| Anti-doping (information only) | AICAR: WADA Prohibited List, class S4. |
| International | The classification in Section 2 applies equally under EU CLP (Regulation (EC) 1272/2008) and other UN GHS implementations; peptides of this kind are generally not registered under REACH (research and development use). |
16Other information
| Revision | Revision 1.0, October 3, 2026 โ first issue. Prepared by PrymaLab Analytical, PrymaLab LLC. |
|---|---|
| Classification method | Substance classification adopted from the supplier safety data sheets listed below, with the PrymaLab policy adjustments stated in Section 11. Policy: Cayman Chemical is the primary reference for research peptides and novel small molecules and Sigma-Aldrich/Merck for commodity chemicals; a more conservative manufacturer or ECHA classification is adopted where internally consistent; SARMs, GLP-1 receptor agonists, GnRH analogues and gonadotropins carry reproductive-toxicity classifications by expert judgement. |
| Sources consulted | Cayman Chemical; TCI; ChemicalBook. |
| Abbreviations | ATE acute toxicity estimate ยท CAS Chemical Abstracts Service ยท GHS Globally Harmonized System ยท HCS Hazard Communication Standard ยท IARC International Agency for Research on Cancer ยท LD50/LC50 median lethal dose/concentration ยท NTP National Toxicology Program ยท OEL occupational exposure limit ยท PEL permissible exposure limit ยท STOT specific target organ toxicity ยท TLV threshold limit value ยท WADA World Anti-Doping Agency. |
