SECTION 1: INTRODUCTION

5-amino-1-methylquinolinium (commonly abbreviated 5-amino-1MQ) 50 mg – Lab Research Supply is a laboratory grade research chemical classified as a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). While often grouped within peptide research catalogs, it is non-peptidic and valued for mechanistic studies in metabolism, longevity biology, and inflammation. This high purity compound supports scientific research aimed at dissecting methylation flux and NAD+ salvage pathway dynamics.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining NNMT-mediated methylation flux, SAM/SAH balance, and impacts on NAD+ salvage in cellular systems.
• Research has explored its role in adipocyte biology, lipid handling, and cellular energy expenditure pathways relevant to metabolic research.
• In-vitro studies have demonstrated concentration-dependent inhibition of NNMT activity and modulation of 1-methylnicotinamide formation.
• Animal model research suggests utility for probing obesity-related mechanisms, hepatic lipid accumulation pathways, and glucose regulation networks.
• Laboratory investigations focus on inflammatory signaling, fibrotic remodeling models, and tumor cell metabolic adaptations associated with NNMT overexpression.
• Additional work examines neuroinflammation and neuroprotective pathways linked to methyl donor availability in peptide research contexts.

SECTION 3: TECHNICAL SPECIFICATIONS

Purity: ≥98% (HPLC). Form: lyophilized crystalline powder, laboratory grade. Appearance: off-white to pale yellow solid. Molecular formula and exact molecular weight, as well as salt/counter-ion designation, are documented on the lot-specific Certificate of Analysis (COA). CAS number and other identifiers may vary by salt form; current lot details available upon request. Non-peptidic; no sequence information applicable.

SECTION 4: QUALITY ASSURANCE

Produced under controlled laboratory-grade standards with batch-specific third-party characterization (HPLC, MS, and/or NMR). Each lot undergoes identity confirmation, purity assessment, and residual solvent profiling as applicable. A detailed COA is provided for traceability. Acceptance criteria are defined prior to release to ensure a consistent, high purity research chemical for scientific research.

SECTION 5: STORAGE & HANDLING

Store desiccated at -20°C, protected from light. Stable under recommended conditions; avoid repeated freeze-thaw. For in-vitro studies, reconstitute in anhydrous DMSO or suitable solvent, then dilute into assay buffers immediately prior to use; sterile filtration may be performed if required by experimental design. Handle with appropriate PPE and laboratory precautions. Refer to COA for shelf life and lot-specific stability guidance.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. Not a drug, medical device, or diagnostic. For in-vitro studies and controlled scientific research only. Not sterile; not for household, agricultural, or cosmetic use. Buyer assumes all responsibility for safe handling and lawful use.