SECTION 1: INTRODUCTION

ACE-031 1 MG – Lab Research Supply is a recombinant activin receptor type IIB–Fc fusion protein (ActRIIb-Fc), commonly referred to as ACE-031. Classified as a laboratory grade research peptide and ligand-trap fusion protein, ACE-031 modulates TGF-β superfamily signaling in controlled experimental systems. It is valued in current scientific research for probing myostatin/activin pathways relevant to muscle biology, bone physiology, and metabolic regulation in preclinical models.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining myostatin (GDF-8) and activin ligand sequestration and downstream SMAD2/3 signaling modulation.
• Research has explored its role in skeletal muscle hypertrophy mechanisms and prevention of disuse or denervation atrophy in animal models.
• In-vitro studies have demonstrated high-affinity binding to select TGF-β superfamily ligands, including activins and related GDFs.
• Animal model research suggests effects on bone biology, including osteogenic signaling and bone density endpoints.
• Laboratory investigations focus on recovery and regeneration paradigms following muscle injury and exercise-induced microtrauma.
• Studies within metabolic research contexts have assessed impacts on body composition, energy balance, and glucose handling in preclinical settings.

SECTION 3: TECHNICAL SPECIFICATIONS

ACE-031 is supplied as a high purity peptide/protein research chemical in lyophilized form for peptide research and in-vitro studies. Typical purity is ≥98% by SEC-HPLC and SDS-PAGE. Molecular nature: recombinant fusion of the extracellular domain of human ACVR2B (ActRIIb) to human IgG1 Fc, forming a disulfide-linked dimer. Approximate molecular mass: ~95–100 kDa (dimer). Appearance: white to off-white lyophilized powder. Sequence information: ACVR2B ECD fused to IgG1 Fc; precise sequence may vary by construct. CAS: not assigned.

SECTION 4: QUALITY ASSURANCE

Manufactured under GMP-aligned, ISO-certified processes to deliver consistent laboratory grade performance. Each lot undergoes identity confirmation (LC-MS/peptide mapping), purity assessment (HPLC, SDS-PAGE), and endotoxin testing as applicable. A detailed Certificate of Analysis (CoA) is provided for full traceability, including batch number, analytical results, and storage recommendations. Routine batch testing and retention sampling support reproducibility across studies.

SECTION 5: STORAGE & HANDLING

Store lyophilized ACE-031 at –20°C or below, protected from light and moisture. When reconstituting, use sterile water or neutral buffered saline; inclusion of carrier protein (e.g., 0.1% BSA) may reduce adsorption. Prepare aliquots and avoid repeated freeze–thaw cycles. Short-term stability for reconstituted solutions is enhanced at 2–8°C; for longer-term storage, freeze at –20°C or –80°C. Handle this research peptide using appropriate PPE and aseptic technique. Shelf life is optimal when unopened and stored as directed.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. This research chemical is not a drug, food, cosmetic, or household item and must not be repackaged for consumer use. Use only in controlled scientific research or in-vitro studies.