SECTION 1: INTRODUCTION

FOXO4 10 MG – Lab Research Supply is a synthetic research peptide derived from the forkhead box protein O4 interaction domain, commonly abbreviated as FOXO4 (FOXO4-derived peptide). Classified as a laboratory-grade peptide analog used to probe protein–protein interactions, it is valued in scientific research for interrogating pathways linked to cellular senescence and stress responses. Its relevance stems from growing interest in FOXO4–p53 signaling and downstream effects within aging biology and metabolic research.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining FOXO4–p53 interactions and their influence on cellular senescence pathways and stress signaling.
• Research has explored its role in modulating markers associated with DNA damage response and cell cycle arrest in controlled laboratory systems.
• In-vitro studies have demonstrated utility for probing senescence-associated secretory phenotype (SASP) signaling and transcriptional regulation.
• Animal model research suggests utility for studying tissue homeostasis biomarkers and oxidative stress readouts in preclinical settings.
• Laboratory investigations focus on apoptosis-related pathways, mitochondrial function assessments, and nuclear localization dynamics of key transcription factors.
• Employed in peptide research to evaluate protein complex disruption and mechanistic mapping within longevity and metabolic research contexts.

SECTION 3: TECHNICAL SPECIFICATIONS

Purity: ≥98% (HPLC). Form: Lyophilized powder, laboratory grade. Appearance: White to off-white, hygroscopic solid. Sequence: FOXO4-derived peptide corresponding to the p53-binding interface; specific sequence, modifications, and counterion reported on the Certificate of Analysis. Molecular weight and formula: Provided on the COA (peptide-specific). CAS: Not assigned for this research chemical. Solubility: Sterile water or suitable aqueous buffer; mild agitation recommended.

SECTION 4: QUALITY ASSURANCE

Produced under GMP-aligned procedures within a controlled quality system. Each lot is verified by analytical HPLC and LC-MS for identity and high purity peptide confirmation. Batch-specific COA is available, detailing purity, identity, and content. Additional characterization (peptide mapping, residual solvents, and endotoxin screening) performed as applicable. Traceable batch records support reproducibility for scientific research.

SECTION 5: STORAGE & HANDLING

Store lyophilized material at -20°C or below, desiccated and protected from light. Stable for 24 months unopened under recommended conditions. For reconstitution, use sterile water or appropriate buffer; prepare aliquots to avoid repeated freeze–thaw. Store reconstituted solutions at -20°C to -80°C and use within 2–4 weeks depending on buffer. Handle as a research chemical with appropriate PPE and aseptic technique.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. Not a drug, diagnostic, or household item. For in-vitro studies and controlled experimental use only; age 18+.