SECTION 1: INTRODUCTION

Cagrilintide 2.5 mg + Samaglutide 2.5 mg – Lab Research Supply combines two laboratory-grade, synthetic peptide analogs for research: cagrilintide (AM833), a long-acting amylin/calcitonin receptor agonist, and semaglutide (also referred to as “Samaglutide” per product labeling), a GLP-1 receptor agonist. This research peptide blend is valued in contemporary metabolic and endocrinology research for dissecting complementary pathways in energy balance, nutrient-driven signaling, and gastrointestinal neuroendocrine regulation.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining amylin and GLP-1 receptor pharmacology, including receptor binding, cAMP signaling, and β-arrestin recruitment in in-vitro studies.
• Research has explored its role in metabolic pathway mapping related to appetite signaling, gastric motility, and nutrient-induced hormonal responses in preclinical models.
• In-vitro studies have demonstrated utility for comparative potency, efficacy, and biased agonism profiling at the GLP-1 and amylin/calcitonin receptor systems.
• Animal model research suggests effects on food intake regulation, meal patterning, and energy expenditure mechanisms, informing peptide research on energy homeostasis.
• Laboratory investigations focus on combination-agonist interactions, dosing paradigms, and pharmacokinetic/pharmacodynamic relationships relevant to scientific research in metabolic signaling.

SECTION 3: TECHNICAL SPECIFICATIONS

Each vial contains cagrilintide 2.5 mg and semaglutide 2.5 mg as a lyophilized powder, laboratory grade, with each component typically ≥98% purity by HPLC. Appearance: white to off-white lyophilized solid. Approximate molecular weights: cagrilintide ~3.9–4.1 kDa; semaglutide ~4113.6 Da (exact mass depends on salt/counterion; refer to COA). CAS: Semaglutide 910463-68-2; cagrilintide CAS provided on request/COA. Amino acid sequences correspond to published analogs; detailed sequence data and analytical characterization are available upon request.

SECTION 4: QUALITY ASSURANCE

Manufactured under GMP-aligned procedures for research chemicals with rigorous in-process controls. Each lot is verified by HPLC and high-resolution mass spectrometry; identity, purity, and peptide content are batch-tested. A detailed Certificate of Analysis is supplied, including chromatograms and MS data. Quality management follows documented SOPs, with full traceability and release criteria to ensure a high purity peptide suitable for peptide research.

SECTION 5: STORAGE & HANDLING

Store unopened vials at -20°C or below, protected from light and moisture. When properly stored, lyophilized material is typically stable for 12 months. For reconstitution, use sterile water or appropriate buffer; for adsorption-sensitive applications, consider carrier proteins (e.g., 0.1% BSA) and aliquot to avoid freeze-thaw cycles. Short-term (≤7 days) storage of reconstituted solutions at 2–8°C; longer-term at -20°C. Handle with appropriate PPE; avoid repeated freeze-thaw and vigorous agitation.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. Not sterile; not a drug, diagnostic, or household item. Use in-vitro studies and controlled laboratory settings only.