SECTION 1: INTRODUCTION

AICAR 50 MG – Lab Research Supply is 5-aminoimidazole-4-carboxamide riboside (AICA riboside; acadesine), a synthetic adenosine analog and well-characterized AMPK pathway activator. Classified as a laboratory-grade research chemical frequently used alongside peptide research workflows, it is valued in scientific research for probing cellular energy sensing, metabolic regulation, and stress-response signaling.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining AMP-activated protein kinase (AMPK) activation and downstream effects on glucose and lipid metabolism.
• Research has explored its role in mitochondrial biogenesis, cellular energy homeostasis, and metabolic reprogramming in vitro.
• In-vitro studies have demonstrated modulation of mTOR/ULK1 signaling and autophagy-related pathways.
• Animal model research suggests utility in probing exercise metabolism, endurance-related bioenergetics, and tissue stress response models.
• Laboratory investigations focus on neuroinflammation, neuroprotection paradigms, and oxidative stress signaling.
• Studies have evaluated anti-inflammatory signaling dynamics, including NF-κB pathway activity and cytokine expression profiles.

SECTION 3: TECHNICAL SPECIFICATIONS

Purity: ≥98% (high purity peptide-grade material). Molecular formula: C9H14N4O5; Molecular weight: 258.23 g/mol. CAS: 2627-69-2. Synonyms: AICA riboside, Acadesine. Form: lyophilized powder, white to off-white, hygroscopic. Solubility: water, aqueous buffers, or DMSO (researchers should optimize for specific in-vitro studies). This compound is a small-molecule nucleoside analog; no peptide sequence applies.

SECTION 4: QUALITY ASSURANCE

Produced in a GMP-compliant, ISO-accredited environment to laboratory-grade specifications. Each lot is validated by HPLC for purity and LC-MS for identity; additional NMR confirmation performed where applicable. A lot-specific Certificate of Analysis (CoA) is available. Batch-level traceability, retention samples, and stability monitoring support consistent performance in scientific research.

SECTION 5: STORAGE & HANDLING

Store lyophilized material at 2–8°C, desiccated and protected from light. For reconstituted solutions, aliquot and store at −20°C; avoid repeated freeze–thaw cycles. Recommended reconstitution in sterile water or appropriate buffer/DMSO to desired working concentration for peptide research and in-vitro assays. Shelf life: up to 24 months lyophilized under recommended conditions. Handle using appropriate PPE in a chemical fume hood.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. For research peptide category placement only; this is a research chemical, not a drug, diagnostic, or dietary supplement. Not for household use; keep out of reach of children and animals. By purchasing, you agree to responsible handling and institutional oversight requirements.