SECTION 1: INTRODUCTION

Cagrilintide 5 mg + Samaglutide 5 mg – Lab Research Supply is a laboratory grade peptide blend combining cagrilintide (AM833), a long-acting synthetic amylin receptor agonist analog, with samaglutide (also known as semaglutide; SEMA), a GLP-1 receptor agonist peptide analog. This research peptide combination is valued in current scientific research for probing complementary pathways regulating energy balance, gastric motility, and nutrient-responsive signaling. The blend supports controlled peptide research in metabolic biology without therapeutic claims.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining coordinated GLP-1R and amylin/calcitonin receptor signaling and downstream cAMP/PKA pathways.
• Research has explored its role in elucidating central and peripheral mechanisms of energy intake regulation in preclinical models.
• In-vitro studies have demonstrated receptor pharmacology relevant to GLP-1R activation and amylin receptor engagement, informing peptide structure–activity relationships.
• Animal model research suggests utility for characterizing gastric emptying dynamics and nutrient-induced neuroendocrine responses.
• Laboratory investigations focus on peptide stability, binding kinetics, and co-agonism effects in metabolic signaling networks.
• Evaluated in peptide research protocols assessing synergistic modulation of appetite-related neuronal circuits and pancreatic islet signaling in controlled settings.

SECTION 3: TECHNICAL SPECIFICATIONS

High purity peptide blend (≥98% by HPLC), supplied as lyophilized powder in equimass amounts (5 mg cagrilintide + 5 mg samaglutide). Appearance: white to off-white lyophilized solid; laboratory grade research chemical. Molecular details: semaglutide MW ~4113.6 Da (commonly referenced formula C187H291N45O59); cagrilintide approx. 4.0 kDa (exact values vary with salt form and acylation state). Sequence information: semaglutide is a GLP‑1 (7–37) analog with Aib8 and C18 diacid acylation at Lys26 via spacer; cagrilintide is an acylated amylin analog engineered for prolonged receptor engagement. CAS: provided on Certificate of Analysis for each component.

SECTION 4: QUALITY ASSURANCE

Manufactured under stringent GMP-aligned procedures for research use. Each batch is third-party tested by HPLC and LC–MS for identity and purity, with peptide content and residual solvent analysis performed as applicable. A lot-specific Certificate of Analysis is available, and batch release requires conformance to preset specifications for purity, identity, and appearance. Quality systems ensure traceability from raw materials to finished vials.

SECTION 5: STORAGE & HANDLING

Store lyophilized vials at −20°C or below, desiccated and protected from light. Stable for 24 months unopened under recommended conditions. For reconstitution, use sterile water or appropriate buffer; gently invert to dissolve, do not vortex. After reconstitution, aliquot, filter if required for in-vitro studies, and store at −20°C to −80°C; avoid repeated freeze–thaw cycles. Handle with appropriate PPE in a controlled laboratory environment.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. For in-vitro studies and ex-vivo experimental use only. Not a drug, diagnostic, or household item. Buyer assumes all responsibility for safe handling and use in scientific research.