SECTION 1: INTRODUCTION

Alprostadil 20 mcg (Prostaglandin E1, PGE1; 11α,15S-dihydroxy-9-oxo-prosta-5Z,13E-dien-1-oic acid) is a laboratory-grade eicosanoid research chemical widely used as a reference prostaglandin. Classified as a bioactive lipid mediator rather than a peptide, Alprostadil is valued for probing EP receptor pharmacology, vascular signaling, and platelet biology. Its well-characterized mechanism makes it a reliable tool compound for scientific research and in-vitro studies where precise modulation of cAMP/PKA pathways is required.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining EP receptor subtype (PTGER1–PTGER4) activation, cAMP accumulation, and smooth muscle signaling cascades.
• Research has explored its role in modulating platelet aggregation and microcirculatory dynamics in ex vivo and cell-based models.
• In-vitro studies have demonstrated effects on endothelial barrier function, nitric oxide pathways, and angiogenic signaling networks.
• Animal model research suggests utility as a reference agonist for vascular reactivity, ischemia–reperfusion pathways, and tissue perfusion metrics.
• Laboratory investigations focus on inflammatory mediator cross-talk within COX/prostaglandin pathways and neurovascular coupling mechanisms.
• Studies also evaluate formulation stability, delivery matrices, and co-administration paradigms alongside peptide research modulators to dissect synergistic signaling.

SECTION 3: TECHNICAL SPECIFICATIONS

This high-purity research chemical is manufactured at ≥98% purity (HPLC). Molecular formula: C20H34O5; Molecular weight: 354.49 g/mol. Supplied as a stabilized, laboratory-grade solid (typically lyophilized), appearance white to off-white. CAS: 745-65-3. Solubility: ethanol, DMSO; dilute into aqueous buffers with carrier protein as appropriate. Sequence information: not applicable (non-peptidic eicosanoid).

SECTION 4: QUALITY ASSURANCE

Produced under GMP-aligned, ISO 9001:2015 quality systems with stringent raw material controls. Each lot is verified by HPLC for purity and LC-MS/NMR for identity; residual solvents (GC) and water content (Karl Fischer) are monitored. A lot-specific Certificate of Analysis is provided, and batch traceability is maintained to support reproducible scientific research. Routine third-party testing safeguards consistency across production runs.

SECTION 5: STORAGE & HANDLING

Store unopened at -20°C, desiccated, and protected from light. For reconstitution, prepare concentrated stocks in ethanol or DMSO; further dilute in buffer containing inert carrier (e.g., 0.1% BSA). Avoid repeated freeze–thaw cycles by aliquoting. Shelf life: 24 months unopened under recommended conditions; reconstituted stocks are typically stable for weeks at -20°C and for extended periods at -80°C. Handle using appropriate PPE and aseptic techniques suitable for research chemicals.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA. This item is supplied as a research chemical; while often listed alongside research peptide products and high purity peptide collections, Alprostadil itself is not a peptide.