SECTION 1: INTRODUCTION

Dermorphin 5 mg – Lab Research Supply is a laboratory grade research peptide corresponding to the amphibian-derived heptapeptide Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (commonly abbreviated Dermorphin). Classified as a potent and selective μ-opioid receptor agonist peptide, it is widely utilized as a research chemical in peptide research to interrogate GPCR pharmacology and nociceptive signaling pathways. Its high receptor selectivity and defined structure make Dermorphin for research a valuable tool for controlled in-vitro studies and preclinical scientific research.

SECTION 2: RESEARCH APPLICATIONS

• Investigated in studies examining μ-opioid receptor binding affinity, selectivity, and kinetics in receptor profiling assays.
• Research has explored its role in GPCR signaling bias, including G protein versus β-arrestin pathways and receptor internalization.
• In-vitro studies have demonstrated utility in mapping structure–activity relationships (SAR) of opioid peptides and D-amino acid substitutions.
• Animal model research suggests use in characterizing nociceptive circuitry and central/peripheral opioid receptor distributions under controlled conditions.
• Laboratory investigations focus on enzymatic stability, peptidase susceptibility, and formulation strategies impacting peptide bioavailability in model systems.
• Evaluated in receptor competition, radioligand binding, and downstream second-messenger assays to benchmark assay performance.

SECTION 3: TECHNICAL SPECIFICATIONS

This high purity peptide is supplied as a lyophilized powder for maximum stability and precise dosing. Purity: ≥98% (HPLC). Molecular formula: C40H50N8O10; Molecular weight: ~802.9 g/mol. Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. Appearance: white to off-white, lyophilized solid. Form: synthetic peptide, amide C-terminus. Counter-ion information and CAS number are batch-specific and provided on the Certificate of Analysis (COA) upon request.

SECTION 4: QUALITY ASSURANCE

Synthesized under stringent, GMP-aligned quality systems for laboratory-grade production. Each lot is tested by analytical HPLC and LC–MS for identity and purity; additional orthogonal methods may be employed as needed. Batch-specific COA is available, detailing purity, identity, and counter-ion content. Traceability, batch retention, and release criteria follow internal SOPs to ensure consistent, high purity peptide performance for scientific research.

SECTION 5: STORAGE & HANDLING

Store lyophilized material at −20°C, protected from light and moisture. When properly stored, shelf life is up to 24 months. For reconstitution, use sterile water, buffer, or compatible solvent (e.g., dilute acetic acid or DMSO), then aliquot and freeze at −20°C to avoid repeated freeze–thaw cycles. Short-term (≤1 week) storage at 2–8°C is acceptable after reconstitution; stability depends on solvent and concentration. Handle with appropriate PPE and aseptic technique; product is non-sterile.

SECTION 6: COMPLIANCE & DISCLAIMERS

This product is intended exclusively for laboratory research use by qualified professionals. Not approved for human consumption, veterinary applications, or clinical use. Purchasers must be affiliated with a research institution or possess appropriate qualifications. All research must comply with applicable local, state, and federal regulations. The statements regarding research applications have not been evaluated by the FDA.