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Certificate no.
PL-26-00308
Verification key
JLAP6XMZ
Scan or enter both at prymalab.net/testing/verify
Certificate of Analysis · Lot release
SR-9011 5 mg Capsules
Lot PL-2610-195 · Capsules · Label claim 5 mg per capsule
Tested in-house by PrymaLab
In-house analytical result, not an independent third-party test
Lot / batch number
PL-2610-195
Date made
2026-10-07
Date of analysis
2026-10-08
Date issued
2026-10-14
Retest / expiry
2028-10-07
Units in lot / sampled
364 / 2
Storage
—
Certificate type
Lot COA, 2 pages
Compound
SR-9011
SR9011, REV-ERB agonist
CAS number
1379686-29-9
Molecular formula
C23H31ClN4O3S
Theoretical mass (avg.)
479.04 Da
Structure
Purity · RP-HPLC, area %
99.66%
Specification ≥ 99.0% • main peak at 12.73 min
Identity · Observed Mass
479.03 Da
Theoretical 479.04 Da • −0.01 Da (21 ppm)
Overall conclusion
PASS
Meets every specification for the tests performed
Test
Method
Specification
Result
Conclusion
Identity (mass)
LC-MS, ESI positive
Theoretical ± 1.0 Da
479.03 Da
PASS
Purity
RP-HPLC, UV 254–306 nm, area%
≥ 99.0%
99.66%
PASS
Largest impurity
RP-HPLC, area%
≤ 1.0%
0.21% (RT 13.50)
PASS
Capsule content
Content vs label claim
4.5–5.5 mg/cap
4.91 mg/cap
PASS
Bacterial endotoxin
LAL, kinetic
—
—
N/A
Aerobic count (TAMC)
USP <61>
< 10 CFU/g
< 10 CFU/g
PASS
Yeast & mold (TYMC)
USP <61>
< 10 CFU/g
< 10 CFU/g
PASS
E. coli
USP <62>
Absent
Absent
PASS
1HPLC chromatogram
Data file: PL-2610-195-HPLC.raw · Column C18, 150 × 4.6 mm · UV 254–306 nm
Peak plot drawn from the integrated peak table (area %, log scale); it is not the instrument trace, which is retained in PL-2610-195-HPLC.raw. † Nominal reference retention time for the assigned impurity; the main-peak RT is observed in this lot.
PrymaLab
Certificate of Analysis · continued
SR-9011 5 mg Capsules · Lot PL-2610-195 · Certificate PL-26-00308
Lot PL-2610-195
Method, peak table and approval
2HPLC method · PL-2610-195-HPLC.raw
Instrument
Waters Alliance e2695
Data System
Empower 3
Detector
UV absorbance
Detection Wavelength
254–306 nm
Column
C18, 150 × 4.6 mm, 3.5 µm
Mobile Phase A
0.1% TFA in water
Mobile Phase B
0.1% TFA in MeCN
Gradient
5–95% B over 25 min (linear)
Flow Rate
1.0 mL/min
Column Temperature
40 °C
Injection Volume
10 µL
3Gradient program
Time (min)
% A
% B
0.0
95
5
25.0
5
95
4Peak table
Peak
RT (min)
Area
Area %
1
11.40 †
—
0.08
2
12.73
—
99.66
3
13.50 †
—
0.21
4
14.10 †
—
0.05
Total
—
100.00
Peaks: 1 unidentified impurity; 2 main peak (SR-9011); 3 unidentified impurity; 4 unidentified impurity · Area % from the integrated peak table (absolute areas are not part of the lot-release export) · † nominal reference RT for the assigned impurity · Purity = main peak area ÷ total integrated area × 100, to two decimals; main peak shaded.
5Identity by mass spectrometry
Instrument
Waters SQD
Ionization / Mode
ESI, positive
Reference m/z (ion)
480.05 [M+H]+
Deconvoluted Mass
479.03 Da
Theoretical Mass
479.04 Da
Difference
−0.01 Da (21 ppm)
Data File
PL-2610-195-MS.d
Acceptance
Within ± 1.0 Da
6Additional tests
Test
Performed by
Date
Report / file
Content vs label claim
PrymaLab Analytical
2026-10-08
—
Microbial limits (USP <61>/<62>)
PrymaLab Analytical
2026-10-14
—
A test with no row here was not performed on this lot. Outside-laboratory reports, when used, are attached and named below.
7Review and approval
D. Reynolds Analyst · performed the testing Date: 2026-10-14
S. Calloway Reviewer · checked against raw data Date: 2026-10-14
M. Phelps Lab Director · approved for release Date: 2026-10-14
